Results 71 to 80 of about 1,791,801 (336)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
The Right to Die: Legalizing Medical Assistance in Dying in Canada
Health Reform Observer - Observatoire des Réformes de Santé, 2017 Permitting medical assistance in dying has been a contentiously debated issue in Canada for decades. In June of 2016, the federal government passed legislation that amended the Criminal Code to permit eligible adults to request and receive medical ...
Noushon Farmanara
doaj +3 more sources
Legal Problems of qualification of euthanasia in Kazakhstan
Хабаршы. Заң сериясы, 2017 The article deals with the problem of the legal qualification of euthanasia in Kazakhstan, as well as proposals to allocate an independent structure less dangerous kind of murder.
Kopbayev D.Z., Tleuov T.M.
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Proxy voting in the joint stock company and the limited liability company [PDF]
, 2010 Die Ausübung des Stimmrechts durch einen Stellvertreter stellt eine Möglichkeit für einen Aktionär oder einen Gesellschafter dar, sein Stimmrecht auch dann auszuüben, wenn er nicht persönlich an der Haupt- bzw.
Lieberam-Schmidt, Sabine
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Collaboration and research imperatives for a growing right-to-die movement. [PDF]
Can J Public Health, 2023 Dankwort J.
europepmc +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
, 2014 This entry opens with a concise history of the right to die movement. Then it provides a conceptual framework, explaining key terms that are often utilized by those who advocate physician aid-in-dying: liberty, autonomy, dignity, respect, concern, quality of life and suffering.
openaire +3 more sources
Quando a morte é um ato de cuidado: obstinação terapêutica em crianças
Cadernos de Saúde PúblicaEste artigo discute um caso específico de recusa de obstinação terapêutica para um bebê de oito meses, portador de Amiotrofia Espinhal Progressiva Tipo I, uma doença genética incurável, degenerativa e com curto prognóstico médico de sobrevida.
Debora Diniz
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