Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel+2 more
wiley +1 more source
Material plastic properties characterization using a generic algorithm and finite element method modelling of the plane-strain small punch test [PDF]
In this paper, a novel plane strain small punch test (SPT) method is proposed for material plastic properties characterization. The plane strain SPT is different from the standard SPT in the two ways: (a) a long thin rectangular specimen (with dimensions
Boyle, Jim+5 more
core +1 more source
A Life Below the Threshold? Examining Conflict Between Ethical Principles and Parental Values In Neonatal Treatment Decision Making [PDF]
Three common ethical principles for establishing the limits of parental authority in pediatric treatment decision making are the harm principle, the principle of best interest, and the threshold view.
Cunningham, Thomas V.
core +1 more source
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche+2 more
wiley +1 more source
The Right to Die: Legalizing Medical Assistance in Dying in Canada
Permitting medical assistance in dying has been a contentiously debated issue in Canada for decades. In June of 2016, the federal government passed legislation that amended the Criminal Code to permit eligible adults to request and receive medical ...
Noushon Farmanara
doaj +3 more sources
The adaptation of the therapeutic effort: science, technology and society
The scientific and technological development has an impact in all the spheres of society. The adaptation of the therapeutic effort is example of this. The author’s motive to carry out this bibliographic review article laid on the technological abuse as a
Gilberto de Jesús Betancourt-Betancourt+2 more
doaj
Diretivas antecipadas de vontade: percurso histórico na América Latina
Resumo As diretivas antecipadas de vontade são instrumento para garantir ao paciente o direito de decidir sobre seus cuidados de saúde, especialmente os relacionados ao fim da vida.
Renata da Silva Fontes Monteiro+1 more
doaj +1 more source
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt+8 more
wiley +1 more source
A comparison of medical education in Germany and the United States: From applying to medical school to the beginnings of residency [PDF]
Both Germany and the United States of America have a long tradition of science and medical excellence reaching back as far as the nineteenth century. The same tribute must be paid to the medical educational system in both countries.
Gansbacher, Bernd+3 more
core +2 more sources
Legal Problems of qualification of euthanasia in Kazakhstan
The article deals with the problem of the legal qualification of euthanasia in Kazakhstan, as well as proposals to allocate an independent structure less dangerous kind of murder.
Kopbayev D.Z., Tleuov T.M.
doaj