Results 1 to 10 of about 2,867,670 (393)
The 1,2,3-triazole ring as a bioisostere in medicinal chemistry
Drug Discovery Today, 2017 1,2,3-Triazole is a well-known scaffold that has a widespread occurrence in different compounds characterized by several bioactivities, such as antimicrobial, antiviral, and antitumor effects. Moreover, the structural features of 1,2,3-triazole enable it to mimic different functional groups, justifying its wide use as a bioisostere for the synthesis of
BONANDI, ELISA +5 more
semanticscholar +5 more sources
Put a ring on it: application of small aliphatic rings in medicinal chemistry
RSC Medicinal Chemistry, 2021 Aliphatic small rings including cyclopropanes, cyclobutanes, oxetanes, azetidines and bicyclo[1.1.1]pentanes have been increasingly exploited in medicinal chemistry. This review summarises judicious successful application and reported limitations of these ring systems.
Matthias R. Bauer +6 more
openaire +4 more sources
Efficient ring perception for the Chemistry Development Kit [PDF]
Journal of Cheminformatics, 2014 The Chemistry Development Kit (CDK) is an open source Java library for manipulating and processing chemical information. A key aspect in handling chemical structures is the determination of the chemical rings. The rings of a structure are used areas including descriptors, stereochemistry, similarity, screening and atom typing. The CDK includes multiple
May, John W, Steinbeck, Christoph
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Studies in medium ring chemistry
, 1970 Imperial Users ...
Duffin, David, Duffin, David
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Ring polymer quantization of the photon field in polariton chemistry.
Journal of Chemical Physics, 2021 We use the ring polymer (RP) representation to quantize the radiation field inside an optical cavity to investigate polariton quantum dynamics. Using a charge transfer model coupled to an optical cavity, we demonstrate that the RP quantization of the ...
Sutirtha N Chowdhury +2 more
semanticscholar +1 more source
Inorganics, 2023 We combine operando diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) with on-line mass spectrometry (MS) to study the correlation between the oxidation state of titania-supported IrO2 catalysts (IrO2@TiO2) and their catalytic activity
Phillip Timmer +3 more
doaj +1 more source
Catalytic Cascade Reactions Inspired by Polyketide Biosynthesis
CHIMIA, 2020 Aldol reactions belong to the most important methods for carbon–carbon bond formation and are also involved in one of the most astonishing biosynthetic processes: the biosynthesis of polyketides governed by an extraordinarily sophisticated enzymatic ...
Daniel Moser +6 more
doaj +1 more source
Applied Sciences, 2022 The association of cathepsin proteases in neurobiology is increasingly recognized. Our previous studies indicated that cathepsin-K-deficient (Ctsk−/−) mice have learning and memory impairments.
Denise M. T. Yu +6 more
doaj +1 more source
A Unified Mechanism on the Formation of Acenes, Helicenes, and Phenacenes in the Gas Phase. [PDF]
, 2020 A unified low-temperature reaction mechanism on the formation of acenes, phenacenes, and helicenes-polycyclic aromatic hydrocarbons (PAHs) that are distinct via the linear, zigzag, and ortho-condensed arrangements of fused benzene rings-is revealed. This
Ablikim, Utuq +8 more
core +1 more source