Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Effects of Additional Ring-Fusion Site on Dual Reactivity Based Dynamic Covalent Chemistry
Fa Zhong, Xiaojun Wan, Lei You
openalex +1 more source
Host/guest chemistry: from rings and metals to proteins and drugs
Melissa May Gajewski
openalex +1 more source
Analysis of Tree–ring Chemistry to Interpret Variations in Tree–ring Growth of Larix leptolepis and Cryptomeria japonica in Relation to Atmospheric Environmental Changes in Southern Korea [PDF]
Kye-Han Lee +5 more
openalex +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Some Aspects of the Chemistry of Small Ring Organic Molecules: 1-Azetines, 1-Azetidinones, 3-Oxo-β-sultams and Cyclopropenones [PDF]
Paul A. O’Gorman
openalex
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
PhD Chemistry Community Christmas Symposium Basel 2025
Elias Behling +18 more
doaj +1 more source
Selective Functionalization of 1-substituted-3-arylquinoxalin-2(1<i>H</i>)-ones <i>via</i> C-H activation. [PDF]
Kumar P +4 more
europepmc +1 more source

