Results 71 to 80 of about 9,389 (255)

Synthesis of 2H-Chromenes via Hydrazine-Catalyzed Ring-Closing Carbonyl-Olefin Metathesis

, 2019
The catalytic ring-closing carbonyl-olefin metathesis (RCCOM) of O-allylsalicylaldehydes to form 2H-chromenes is described. The method utilizes a [2.2.1]-bicyclic hydrazine catalyst and operates via a [3+2]/retro-[3+2] metathesis manifold. The nature of
Tristan, Lambert, Yunfei, Zhang, Janis, Jermaks, Samantha N., Macmillan   +3 more
core   +1 more source

Nucleophilic Gallyl Anions Enable Ga─Au Bimetallic Ammonia Activation

Angewandte Chemie, EarlyView.
Unlocking gallyl nucleophiles: Counterion control enables formation of an unsupported gallyl─gold complex. Gold coordination induces a polarity switch at gallium, enabling cooperative activation of NH3 and related N─H/O─H substrates under mild conditions.
Hellen Videa, Keelan M. Byrne, Tobias Krämer, Antonio J. Martínez‐Martínez   +3 more
wiley   +2 more sources

Olefin Metathesis Reaction in Water and in Air Improved by Supramolecular Additives

Molecules, 2015
A range of water-immiscible commercially available Grubbs-type precatalysts can be used in ring-closing olefin metathesis reaction in high yields. The synthetic transformation is possible in pure water under ambient conditions.
Jasmine Tomasek, Miriam Seßler, Harald Gröger, Jürgen Schatz   +3 more
doaj   +1 more source

Synthesis of spirocyclic thiazolidinediones using ring-closing metathesis and one-pot sequential ring-closing/cross metathesis

, 2011
A novel synthetic route to spirocyclic thiazolidinediones is reported by utilizing ring-closing metathesis (RCM). A selective cross metathesis (CM) of N-allyl azaspiro derivatives with different olefins has been demonstrated to prepare substituted ...
Paladhi, Sushovan, Dash, Jyotirmayee, Sushovan Paladhi, Dhara, Kalyan, Midya, Ganesh Chandra, Jyotirmayee Dash, Kalyan Dhara, Ganesh Chandra Midya   +7 more
core   +1 more source

Dual Activation of H2 and CO2 by a Pincer‐Type Ni–Zn Heterobimetallic Complex

Angewandte Chemie, EarlyView.
A bimetallic Ni−Zn complex performs sequential activations of H2 (1 equiv) and CO2 (2 equiv). This bimetallic cooperativity is attributed to the weak Lewis acidic nature of Zn(II), which promotes fluxional ligand binding. Namely, an X‐type ligand at Ni, where X is hydride or formate, toggles between two different binding modes: bridging Zn(μ‐X)Ni and ...
Krishnendu Dey, Matthias Borowski, Gregor Schnakenburg, Connie C. Lu   +3 more
wiley   +2 more sources

Consequences of the electronic tuning of latent ruthenium-based olefin metathesis catalysts on their reactivity

Beilstein Journal of Organic Chemistry, 2015
Two ruthenium olefin metathesis initiators featuring electronically modified quinoline-based chelating carbene ligands are introduced. Their reactivity in RCM and ROMP reactions was tested and the results were compared to those obtained with the parent ...
Karolina Żukowska, Eva Pump, Aleksandra E. Pazio, Krzysztof Woźniak, Luigi Cavallo, Christian Slugovc   +5 more
doaj   +1 more source

Ring-Closing Metathesis on Commercial Scale: Synthesis of HCV Protease Inhibitor Simeprevir

, 2019
The key macrocyclization step in the synthesis of simeprevir, a hepatitis C virus (HCV) antiviral drug, was studied. N-Boc substitution on the diene precursor changes the site of insertion of the metathesis catalyst and, consequently, the kinetic model ...
Dirk Van Den Heuvel (6369197), Jef Cuypers (6369191), Wouter Couck (6369194), András Horváth, Grégori Binot (6369188), Dominique Depré (3818533), Wim A. A. Vermeulen, Jef Cuypers, Wouter Couck, Syuzanna R. Harutyunyan (2534917), Stijn L. Wuyts (6369185), Stijn L. Wuyts, Dirk Van Den Heuvel, Syuzanna R. Harutyunyan, András Horváth (6369182), Wim A. A. Vermeulen (12332692), Grégori Binot, Dominique Depré   +17 more
core   +1 more source

Ring-Closing Metathesis in Methanol and Water

, 2016
The ring-closing metathesis (RCM) of acyclic dienes in both methanol and water has been achieved through the use of water-soluble ruthenium alkylidenes. These alkylidenes react readily with acyclic olefins in protic solvents, but they do not cyclize α,ω ...
Thomas A. Kirkland (1262970), David M. Lynn (1327461), Robert H. Grubbs (1318044)   +2 more
core   +1 more source

Synthesis of indole-based propellane derivatives via Weiss–Cook condensation, Fischer indole cyclization, and ring-closing metathesis as key steps

Beilstein Journal of Organic Chemistry, 2013
A variety of highly functionalized indole-based [n.3.3]propellane derivatives is described. The synthesis of the propellane derivatives involves a Weiss–Cook condensation, a Fischer indole cyclization, and a ring-closing metathesis as key steps.
Sambasivarao Kotha, Ajay Kumar Chinnam, Arti Tiwari   +2 more
doaj   +1 more source

Rapid, two-pot procedure for the synthesis of dihydropyridinones; total synthesis of aza-goniothalamin

Beilstein Journal of Organic Chemistry, 2020
A fast, protecting-group-free synthesis of dihydropyridinones has been developed. Starting from commercially available aldehydes, a novel one-pot amidoallylation gave access to diene compounds in good yields.
Thomas J. Cogswell, Craig S. Donald, Rodolfo Marquez   +2 more
doaj   +1 more source