Results 131 to 140 of about 830,676 (348)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Ring-Opening Polymerization of 1-Substituted Azetidine. I. Polymerization of 1-β-Cyanoethylazetidine with Cationic Initiators [PDF]
, 1977 Shizunobu Hashimoto +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
QRB DiscoveryThe TRiC/CCT complex assists in the folding of approximately 10% of cytosolic proteins through an ATP-driven conformational cycle, playing a crucial role in maintaining protein homeostasis.
Mingliang Jin +3 more
doaj +1 more source
Ethylene carbonate/cyclic ester random copolymers synthesized by ring-opening polymerization
, 2015 William Guérin +5 more
openalex +2 more sources
Inside Cover: Design of Peptidyl Thiourea Derivatives as Organocatalysts for the Asymmetric Ring Opening of meso‐Stilbene Oxides (Asian J. Org. Chem. 6/2014) [PDF]
, 2014 Swapandeep Singh Chimni +2 more
openalex +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Boron-chalcogen heterocycles and linear tetraboranes from a cyclic tetra(amino)tetraborane
Nature CommunicationsWhile small carbocyclic rings have long been recognized as pivotal building blocks in chemistry, their all-boron counterparts have remained largely unexplored.
Eva Beck +7 more
doaj +1 more source