Results 131 to 140 of about 1,369,818 (304)
Boron-chalcogen heterocycles and linear tetraboranes from a cyclic tetra(amino)tetraborane
Nature CommunicationsWhile small carbocyclic rings have long been recognized as pivotal building blocks in chemistry, their all-boron counterparts have remained largely unexplored.
Eva Beck +7 more
doaj +1 more source
, 2016 Ring-Opening Reactions of α,β-Epoxy Silanes with Organocopper Reagents: Reaction at Carbon or ...
Da Ma (344152) +3 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The synthesis of some new polymeric materials as potential additives for diesel fuel [PDF]
, 1993 Wax crystal formation in diesel and related hydrocarbon fuels during cold weather is a long standing problem. Current polymeric additives to diesel fuel modify the crystal habit of the wax, in a variety of ways, to improve its performance at low ...
Smith, Carole-Anne
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Identifying Low-Frequency Tree-Ring Variation
, 1991 I propose an approach to provide 95% confidence intervals for a chronology of low-frequency tree-ring variation so that a level of significance or importance for trends can be inferred.
Sheppard, Paul R.
core +2 more sources
Carbon NeutralityCatalytic hydrogenolysis systems of C-O bonds in furan ring, tetrahydrofuran ring and tetrahydropyran ring in biomass-derived cyclic compounds are reviewed.
Keiichi Tomishige +5 more
doaj +1 more source