Results 241 to 250 of about 830,676 (348)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Chemodivergent Synthesis of β‑Phosphonyl Carboxylic Acids and Acylphosphine Oxides via Ring-Opening Addition of Cyclopropenone. [PDF]

Precis Chem
Zhang S, Tang J, Huang Z, Zhang S, Zhang QW.   +4 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Sequence Control in Sulphur-Containing Ring-Opening Co- and Terpolymerisations. [PDF]

Angew Chem Int Ed Engl
Manjunatha BR, Gallizioli C, Fornacon-Wood C, Stephan J, Stühler MR, Plajer AJ.   +5 more
europepmc   +1 more source

Coarse-Grained Simulations Predict Thermosensitivity and Hydrolytic Degradation of Vinyl Copolymers Obtained by Radical Ring-Opening Polymerization [PDF]

Ping Gao, Yingmin Jiang, Tâp Ha‐Duong, Julien Nicolas   +3 more
openalex   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Ring opening and cycloadditions of novel fused 1,2,4-triazines

ARKIVOC, 2003
Zsuzsanna Riedl, György Hajós, Péter Kövér, Gert Kollenz   +3 more
doaj   +1 more source

In Situ NMR and Kinetics Reveal Origins of Regioselectivity Differences for Epichlorohydrin Ring-Opening in Lewis and Brønsted Acid Zeolites. [PDF]

Angew Chem Int Ed Engl
Potts DS, Locht H, Kim S, Lercher JA, Hu JZ, Flaherty DW.   +5 more
europepmc   +1 more source

Accessible ring opening metathesis and atom transfer radical polymerization catalysts based on dimethyl sulfoxide ruthenium(II) complexes bearing N-heterocyclic carbene ligands

, 2018
André Hideki Silva Idehara, Patrik D.S. Gois, Henrique Fernandez, Beatriz E. Goi, Antônio E.H. Machado, Benedito dos Santos Lima Neto, Valdemiro P. Carvalho–Jr   +6 more
openalex   +2 more sources

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source