Results 51 to 60 of about 1,047 (208)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Analysis of Mechanical Behavior of Deepwater Drilling Riser

open access: yesShiyou jixie, 2018
The riser is the key equipment for deepwater drilling. A great deal of theoretical researches and finite element analyses have been carried out on riser,but mainly focused on the mechanical analysis and natural frequency analysis of top tension and ...
Gan Wuxiang, Zhao Honglin, Duan Menglan
doaj  

Parametric instability analysis of the top-tensioned riser in consideration of complex pre-stress distribution

open access: yesAdvances in Mechanical Engineering, 2018
The parametric vibration instability of a riser is studied in consideration of a complex pre-stress distribution. Differential equations of the riser are derived according to Euler–Bernoulli beam theory, and a method to solve the differential equations ...
Leixin Li, Luyun Chen
doaj   +1 more source

Fluid – structure interaction study for the DIFIS System’s composite riser tube

open access: yesJournal of Mechanical Engineering and Sciences, 2018
DIFIS System was developed for oil recovery from shipwrecks and for the elimination of the pollution threat during EU FP-6 framework. The installation time’s reduction in cases of environmental pollution is a crucial factor for DIFIS system design.
S. D. Fanourgakis   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Le comportement mécanique des risers. Influence des principaux paramètres Mechanical Behaviour of Marine Risers Mode of Influence of Principal Parameters

open access: yesOil & Gas Science and Technology, 2006
Cet article a pour but de déterminer les principaux paramètres qui gouvernent le comportement mécanique des risers de forage et de production, et d'expliquer pourquoi et comment ils interviennent.
Sparks C.
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Reconstruction of Riser Profiles by an Underwater Robot Using Inertial Navigation

open access: yesJournal of Robotics, 2012
This paper proposes a kinematic model and an inertial localization system architecture for a riser inspecting robot. The robot scrolls outside the catenary riser, used for underwater petroleum exploration, and is designed to perform several ...
Luciano Luporini Menegaldo   +2 more
doaj   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

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