Results 61 to 70 of about 4,082,751 (347)

Ergonomics evaluation of workplace at car tyre service centre [PDF]

open access: yes, 2009
The project title is to evaluate an ergonomic on workplace at car tyre service centre. Too many people are injured while working in automotive workshops. Questionnaire survey on the workers by through interview session is used to identify a level of body
Abd Rahman, Mohd Nasrull
core  

Key issues on partial least squares (PLS) in operations management research: A guide to submissions [PDF]

open access: yes, 2019
Purpose: This work aims to systematise the use of PLS as an analysis tool via a usage guide or recommendation for researchers to help them eliminate errors when using this tool.
Alfalla Luque, Rafaela   +1 more
core   +4 more sources

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

Decision-making through sustainability [PDF]

open access: yes, 2016
From immemorial time, dams have contributed significantly for the progress of civilizations. For this reason, nowadays, there is a vast engineering heritage.
Aguado de Cea, Antonio   +1 more
core   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

open access: yesMolecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen   +12 more
wiley   +1 more source

Mengapa Proyek Perangkat Lunak Gagal (Penerapan Manajemen Resiko Dalam Proyek Perangkat Lunak) [PDF]

open access: yes, 2010
The greater and problems complex of software development project enables the event of failure. Risk management is an approach to guide minimization or lessens the failure impact.
Afrizal, Y. (Yasmi)
core  

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

Applying tropos to socio-technical system design and runtime configuration [PDF]

open access: yes, 2008
Recent trends in Software Engineering have introduced the importance of reconsidering the traditional idea of software design as a socio-tecnical problem, where human agents are integral part of the system along with hardware and software components ...
Ali, Raian   +4 more
core  

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