Results 101 to 110 of about 1,440,519 (266)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The Newcastle–Ottawa Scale for Assessing the Quality of Studies in Systematic Reviews

Publications
Secondary research is a cornerstone of health sciences, with substantial implications for clinical practice and health policy. Within the systematic review process, a key step is assessing study quality and risk of bias.
Emanuela Gualdi-Russo, Luciana Zaccagni
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Identification of concepts of importance for the assessment of internal validity of in vitro toxicology studies using a modified Delphi technique

Evidence-Based Toxicology
Context In vitro toxicity studies are increasingly being included as evidence in systematic reviews and chemical risk assessments. INVITES-IN, a tool for assessing the internal validity of in vitro studies, is under development in a process consisting of
Gro H. Mathisen, Camilla Svendsen, Gunn E. Vist, Trine Husøy, Heather M. Ames, Angela Bearth, Marc Audebert, Annette Bernhard, Anna Beronius, Ellen M. Bruzell, Emma Di Consiglio, Miles Davenport, Ingrid Druwe, René Geci, Ursula Gundert-Remy, Thomas Hartung, Sebastian Hoffmann, Helena T. Hogberg, Carlijn R. Hooijmans, Lucina E. Lizarraga, Jennifer H. Olker, Pilar Prieto, Joshua F. Robinson, Andrew A. Rooney, Adriano Sebollela, Nicola M. Smith, Eliana Spilioti, Anastasia Spyropoulou, Olga Tcheremenskaia, Emanuela Testai, Amy Wang, Erin Yost, Johanna Zilliacus, Paul Whaley   +33 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Critical appraisal of systematic reviews and meta-analyses: a step-by-step guide for nephrologists

Renal Failure
Background Systematic reviews and meta-analyses play a pivotal role in evidence-based medicine, including nephrology, by consolidating findings from multiple studies. To maximize their utility, rigorous quality assessment during peer review is essential.
Wisit Cheungpasitporn, Wannasit Wathanavasin, Charat Thongprayoon, Wisit Kaewput, Mihály Tapolyai, Tibor Fülöp   +5 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Systematic reviews of clinical laboratory studies: Pilot risk of bias tool developed by consensus

Cochrane Evidence Synthesis and Methods
Introduction Some research studies aim to elucidate pathophysiology by examining blood or tissue markers in relation to clinical findings. In COVID‐19, this has led specialists to promote treatment options based on single studies without systematic ...
Tilly Fox, Beverley J. Hunt, Robert A. S. Ariens, Greg J. Towers, Robert Lever, Paul Garner, Rebecca Kuehn   +6 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source