Results 111 to 120 of about 169,283,811 (262)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Scientific Committee guidance on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments

EFSA Journal
EFSA requested its Scientific Committee to prepare a guidance document on appraising and integrating evidence from epidemiological studies for use in EFSA's scientific assessments. The guidance document provides an introduction to epidemiological studies
EFSA Scientific Committee, Simon More, Vasileios Bampidis, Diane Benford, Claude Bragard, Antonio Hernandez‐Jerez, Susanne Hougaard Bennekou, Konstantinos Koutsoumanis, Claude Lambré, Kyriaki Machera, Ewen Mullins, Soren Saxmose Nielsen, Josef Schlatter, Dieter Schrenk, Dominique Turck, Maged Younes, Tony Fletcher, Matthias Greiner, Evangelia Ntzani, Neil Pearce, Marco Vinceti, Martine Vrijheid, Marios Georgiadis, Andrea Gervelmeyer, Thorhallur I. Halldorsson   +24 more
doaj   +1 more source

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

On Production Function Estimation with Selectivity and Risk Considerations [PDF]

In the estimation of production functions, ignoring risk considerations can cause inefficient estimates, while biased parameter estimates arise in the presence of sample selection.
Nauges, Celine, Koundouri, Phoebe
core  

AI-driven cardiovascular risk prediction in patients with diabetes: bridging algorithmic innovation to equitable clinical application

Frontiers in Medicine
Machine learning models hold promise to revolutionize cardiovascular disease (CVD) prediction in patients with type 2 diabetes, with algorithms such as neural networks demonstrating superior discriminative performance in internal validations.
Hongxuan Li, Zheyi Xu, Yanhui Cen, Xin Liu   +3 more
doaj   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

Risk of bias. Red (−): high risk of bias; Yellow (?): unknown risk of bias; Green (+): low risk of bias.

, 2014
Risk of bias. Red (−): high risk of bias; Yellow (?): unknown risk of bias; Green (+): low risk of bias.
Xia-feng Yang (524991), Yan-hui Li (524988), Feng-yun Wang (524989), Yi-hua Sun (524992), Chun-qing Feng (524990)   +4 more
core   +1 more source

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source

Myopic Loss Aversion, Asymmetric Correlations, and the Home Bias [PDF]

Myopic loss aversion has been used to explain why a high equity premium might be consistent with plausible levels of risk aversion. The intuition is that it plays the role of high risk aversion in portfolio choice.
Kevin Amonlirdviman, Carlos Viana de Carvalho   +1 more
core