Results 121 to 130 of about 1,440,519 (266)
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Clinical and Experimental Dental ResearchObjectives The aim of this study was to evaluate the risk of editorial bias in the field of Dentistry by examining surrogate measures which can be readily extracted from published randomized controlled trials (RCTs) in a journal of high impact factor ...
Momen A. Atieh, Nabeel H. M. Alsabeeha
doaj +1 more source
Confidence bias, hindsight bias and perceptions of risk in motorcyclists
Journal of Psychology & Clinical PsychiatryConfidence bias and hindsight bias were investigated as predictors of perceived levels of risk in a sample of motorcyclists. Confidence bias was predictive of both perceived absolute risk and perceived comparative risk. Hindsight bias was predictive of total absolute risk but was only predictive of comparative risk regarding car drivers and not total ...
openaire +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Abstract Aim: To investigate the risk of selection bias in “low bias” risk rated randomised control trials (RCT). Methods: A systematic literature search of current systematic reviews of RCTs will be conducted. From the identified reviews, RCTs with overall “high bias” and “low bias” RoB 2 risk ratings will be extracted.
Steffen Mickenautsch, Veerasamy Yengopal
openaire +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source