Results 121 to 130 of about 34,967 (216)

Global trends in epilepsy and the Chinese experience: Epidemiological transitions, underlying mechanisms, and integrated strategies (1990–2021)

Neuroprotection, Volume 4, Issue 3, Page 199-212, September 2026.
Epilepsy: Global Trends and the Chinese Experience (1990–2021). The infographic depicts (left) the global distribution of age‐standardized epilepsy DALY rates; (center) the triple inequality gap within China, including regional mortality disparities (9‐fold difference between western and eastern provinces), urban‐rural treatment gaps (60%–90%), and ...
Ting Chen, Mengqiao He, Sijia Basang, Hongyu Ren, Yutong Fu, Yu Li, Xin Shi, Lei Chen   +7 more
wiley   +1 more source

Therapeutic potential of rivaroxaban in the prevention of venous thromboembolism following hip and knee replacement surgery: a review of clinical trial data

, 2011
Louis M KwongDepartment of Orthopaedic Surgery, Harbor-UCLA Medical Center, Torrance, CA, USAAbstract: Rivaroxaban (Bayer AG, Leverkusen, Germany) is a highly selective direct inhibitor of factor Xa.
Kwong LM
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Bleeding Events Associated with Rivaroxaban Therapy in Naive Patients with Nonvalvular Atrial Fibrillation: A Longitudinal Study from a Genetic Perspective with INR Follow-Up

Medicina
Background and Objectives: Rivaroxaban is a direct-acting anticoagulant used to prevent stroke in patients with atrial fibrillation. Rivaroxaban is a substrate for P-glycoprotein, which is encoded by the ABCB1 gene. Rivaroxaban is also metabolized by the
Nur Ul Ain, Niaz Ali, Abid Ullah, Shakir Ullah, Shujaat Ahmad   +4 more
doaj   +1 more source

Net Renal Drug Secretion Critically Requires Significant Contribution of Basal Uptake Transporters: Perspective From Mechanistic Kidney Model Simulation and Integration of Clinical and In Vitro Data

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.
ABSTRACT Renal clearance (CLr) is the net outcome of glomerular filtration, secretion, and reabsorption, which makes the quantitative requirements for net renal secretion difficult to infer from simple clearance models. Using a mechanistic kidney model (MechKiM), we simulated blood‐referenced CLr (CLr,b) for 30,000 virtual drugs (neutral, monoanionic ...
Toshiaki Tsuchitani, Masatoshi Tomi, Yuichi Sugiyama   +2 more
wiley   +1 more source

Platelet function in patients undergoing major non‐cardiac vascular surgery (PLUGS): a prospective cohort study*

Anaesthesia, Volume 81, Issue 9, Page 1236-1244, September 2026.
Summary Introduction Patients who require major vascular surgery often receive antiplatelet therapy for primary or secondary prevention of cardiovascular disease. Clopidogrel resistance and variability in platelet recovery after drug discontinuation pose clinical challenges, particularly for regional anaesthesia and blood management.
Akshay Shah, Grace Polley, Kasia Bera, Keith Maher, Stephen Von‐Kier, Antonio Barbosa, Louis Corrigan, Sabeena Sharma, Peter Baker, Stuart R. McKechnie, Michael J. Desborough, on behalf of the PLUGS Investigators   +11 more
wiley   +1 more source

Effect of Medication Intake on Dental Implant‐Related Outcomes—A Scoping Review

Clinical Oral Implants Research, Volume 37, Issue 9, Page 1033-1056, September 2026.
ABSTRACT Objective The objective of this scoping review was to evaluate the effect of systemic medications on dental implant outcomes in medically compromised patients. Material and Methods Electronic and manual searches were conducted for this scoping review.
Alberto Monje, Maria Costanza Soldini, Emilio Couso‐Queiruga, Álvaro Babiano, Vivianne Chappuis   +4 more
wiley   +1 more source

Prophylactic-Dose Rivaroxaban Transfer Into Human Milk

Direct oral anticoagulants are increasingly used for postoperative thromboprophylaxis, but use is limited in postpartum populations in the absence of data informing transfer into human milk.
Bruno, Ann M., Zinkhan, Erin K., Rower, Joseph E., Allshouse, Amanda A., Shakib, Julie H., Federspiel, Jerome J., Metz, Torri D., Watt, Kevin M., Lim, Ming Y., Job, Kathleen M., Branch, D. Ware   +10 more
core   +1 more source

Is Routine Interruption of Direct Oral Anticoagulants Necessary during Colorectal Endoscopic Mucosal Resection and Hot Snare Polypectomy? A Multicenter Propensity‐Matched Study

Journal of Gastroenterology and Hepatology, Volume 41, Issue 9, Page 2826-2833, September 2026.
ABSTRACT Background and Aims Colorectal endoscopic mucosal resection (EMR) and hot snare polypectomy (HSP) are high‐bleeding‐risk endoscopic procedures, and most clinical guidelines recommend stopping direct oral anticoagulants (DOACs) temporarily or switching to heparin‐bridging therapy (HBT). However, existing evidence is largely derived from cohorts
Yutaka Okagawa, Masanori Sato, Masahiro Hirakawa, Shogo Miura, Naotaka Hayasaka, Yusuke Tomita, Saki Ameda, Ginji Omori, Shutaro Oiwa, Akira Sakurada, Tomoyuki Abe, Shinya Minami, Tetsuya Sumiyoshi, Yasuhiro Nagaoka, Hiroyuki Hisai, Shinichi Katsuki, Kohichi Takada   +16 more
wiley   +1 more source

Hospitalizations for bleeding associated with apixaban versus rivaroxaban according to dose in Medicare beneficiaries

Thrombosis Update
Introduction: Apixaban and rivaroxaban are the most prescribed direct oral anticoagulants, and the safety of different doses in patients at high risk for bleeding is not fully defined.
Luke S. Vest, Seo H. Baik, Fitsum Baye, Kin-Wah Fung, Clement J. McDonald   +4 more
doaj   +1 more source

Oral Rivaroxaban for Symptomatic Venous Thromboembolism

, 2010
BACKGROUND Rivaroxaban, an oral factor Xa inhibitor, may provide a simple, fixed-dose regimen for treating acute deep-vein thrombosis (DVT) and for continued treatment, without the need for laboratory monitoring.
Bauersachs, R., Baker, R.I.
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