Results 71 to 80 of about 3,611 (194)

Evaluation of RKIP gene expression changes of MDA-MB-231 breast cancer cell line after microgravity treatment [PDF]

open access: yesفصلنامه علوم و فناوری فضایی, 2019
Introduction: Gravity is one of the most important forces exposed to the organisms on the earth which affects the cells, molecules and thus the entire of organism.
maryam salavatifar, Zahra Hajebrahimi
doaj   +1 more source

a retrospective cohort study [PDF]

open access: yes, 2015
Background Metastasis of colorectal cancer (CRC) is directly linked to patient survival. We previously identified the novel gene Metastasis Associated in Colon Cancer 1 (MACC1) in CRC and demonstrated its importance as metastasis inducer and prognostic ...
Herrmann, Pia   +5 more
core   +1 more source

A simple quantum cosmology [PDF]

open access: yes, 2001
A simple and surprisingly realistic model of the origin of the universe can be developed using the Friedmann equation from general relativity, elementary quantum mechanics, and the experimental values of h, c, G and the proton mass.
A. Tseytlin   +11 more
core   +3 more sources

Comparison of Chemometric Explorative Multi‐Omics Data Analysis Methods Applied to a Mechanistic Pan‐Cancer Cell Model

open access: yesJournal of Chemometrics, Volume 39, Issue 2, February 2025.
ABSTRACT The analysis of single cell multi‐omics data is a complex task, and many explorative data analysis methods are being used to draw information from such data. This paper compares several of these methods to visualize the output of a mechanistic model under various simulated conditions.
J. A. Westerhuis   +5 more
wiley   +1 more source

MiR-543 Promotes Proliferation and Epithelial-Mesenchymal Transition in Prostate Cancer via Targeting RKIP

open access: yesCellular Physiology and Biochemistry, 2017
Background/Aims: MicroRNAs (miRNAs, miRs) have emerged as important post-transcriptional regulators in various cancers. miR-543 has been reported to play critical roles in hepatocellular carcinoma and colorectal cancer, however, the role of miR-543 in ...
Yang Du   +5 more
doaj   +1 more source

'BioNessie(G) - a grid enabled biochemical networks simulation environment [PDF]

open access: yes, 2008
The simulation of biochemical networks provides insight and understanding about the underlying biochemical processes and pathways used by cells and organisms.
Ajayi, O   +5 more
core  

The Therapeutic Effects of Bioactive Compounds on Colorectal Cancer via PI3K/Akt/mTOR Signaling Pathway: A Critical Review

open access: yesFood Science &Nutrition, Volume 12, Issue 12, Page 9951-9973, December 2024.
This study discussed the therapeutic capacity of various polyphenols, terpenoids, and alkaloids on CRC via the PI3K/Akt/mTOR pathway. Each bioactive component causes various physiological processes, such as triggering free radical production, disruption of mitochondrial membrane potential, cell cycle arrest, inhibition of CRC stem cell migration ...
Kübra Demir   +4 more
wiley   +1 more source

Downregulation of RKIP is associated with poor outcome and malignant progression in gliomas.

open access: yesPLoS ONE, 2012
Malignant gliomas are highly infiltrative and invasive tumors, which precludes the few treatment options available. Therefore, there is an urgent need to elucidate the molecular mechanisms underlying gliomas aggressive phenotype and poor prognosis.
Olga Martinho   +10 more
doaj   +1 more source

Ybcl of uropathogenic escherichia coli suppresses transepithelial neutrophil migration [PDF]

open access: yes, 2012
Uropathogenic Escherichia coli (UPEC) strains suppress the acute inflammatory response in the urinary tract to ensure access to the intracellular uroepithelial niche that supports the propagation of infection. Our understanding of this initial cross talk
Hunstad, David A   +2 more
core   +2 more sources

Energy Landscape Reveals the Underlying Mechanism of Cancer‐Adipose Conversion in Gene Network Models

open access: yesAdvanced Science, Volume 11, Issue 41, November 6, 2024.
Understanding the mechanism of cancer‐adipose conversion (CAC) is a critical and complex challenge in cancer treatment. A systems biology approach combining molecular network modeling and experiments is proposed based on energy landscape theory, which provides an important way to identify optimal drug combinations driving CAC.
Zihao Chen   +4 more
wiley   +1 more source

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