SPINT2 deregulation in prostate carcinoma [PDF]
, 2016 SPINT2 is a tumor suppressor gene that inhibits proteases implicated in cancer progression, like HGFA, hepsin and matriptase. Loss of SPINT2 expression in tumors has been associated with gene promoter hypermethylation; however, little is known about the ...
Filipe Pinto +9 more
core +1 more source
Expression of Raf Kinase Inhibitor Protein (RKIP) is a predictor of uveal melanoma metastasis.
Histology and histopathology, 2014 Melanoma arising from melanocytes within the choroid is the most frequent primary intraocular neoplasm in adults. It is biologically distinct from cutaneous melanoma by a very strong propensity to metastasize the liver. Raf kinase inhibitor protein is a member of an evolutionarily conserved group of proteins called phosphatidylethanolamine-binding ...
CALTABIANO, ROSARIO +8 more
openaire +4 more sources
Decreased microRNA-224 and its clinical significance in non-small cell lung cancer patients [PDF]
, 2014 BACKGROUND: MicroRNA-224 has been proven dysregulated in some human malignancies and correlated with tumor progression. However, its expression and clinical significance in non–small cell lung cancer (NSCLC) is still unclear.
Dan Zhu +6 more
core +2 more sources
Evaluation of RKIP gene expression changes of MDA-MB-231 breast cancer cell line after microgravity treatment [PDF]
فصلنامه علوم و فناوری فضایی, 2019 Introduction: Gravity is one of the most important forces exposed to the organisms on the earth which affects the cells, molecules and thus the entire of organism.
maryam salavatifar, Zahra Hajebrahimi
doaj +1 more source
Narrative-based computational modelling of the Gp130/JAK/STAT signalling pathway. [PDF]
, 2008 BACKGROUND: Appropriately formulated quantitative computational models can support researchers in understanding the dynamic behaviour of biological pathways and support hypothesis formulation and selection by "in silico" experimentation.
A Herrmann +37 more
core +7 more sources
Dynamic proteome profiling of individual proteins in human skeletal muscle after a high-fat diet and resistance exercise. [PDF]
, 2017 It is generally accepted that muscle adaptation to resistance exercise (REX) training is underpinned by contraction-induced, increased rates of protein synthesis and dietary protein availability. By using dynamic proteome profiling (DPP), we investigated
Benndorf R. +9 more
core +1 more source
Insight on the role of RKIP in cancer through key protein partners and cellular protrusions [PDF]
, 2020 Previously, by comparing the cellular processes in which RKIP is implied and by analyzing the function of numerous molecular partners, we have suggested that RKIP may participate in regulating actin reorganization and membrane remodeling. Here, based on the role of RKIP in cancer, we describe the cellular function of five important partners of RKIP ...
openaire +1 more source
Qualitative Modelling of Quasi-homogeneous Effects in ERK and STAT Interaction Dynamics [PDF]
, 2006 On the basis of qualitative analysis of author's model published in previous paper, the stability and temporal behaviour of quasi-homogeneous distributions of ERK-protein concentrations are analyzed in terms of corresponding reaction-diffusion problem ...
Elena Nikolova +3 more
core
Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging [PDF]
, 2011 Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these pathways or upstream activators.
Abrams, Stephen L. +24 more
core +2 more sources
Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source