Overexpression of RKIP and its cross-talk with several regulatory gene products in multiple myeloma
Journal of Experimental & Clinical Cancer Research, 2017 Multiple myeloma (MM) is a clonal plasma-cell neoplastic disorder arising from an indolent premalignant disease known as monoclonal gammopathy of undetermined significance (MGUS).
Anna Shvartsur +3 more
doaj +1 more source
Oncotarget, 2016 Raf kinase inhibitor protein (RKIP) has been shown to be a suppressor of the mitogen-activated protein kinase pathway and is reported to be involved in human malignancy. However, the molecular mechanism of hepatitis B virus (HBV) in regulating RKIP expression is not yet clarified. In this study, we compared RKIP expression in 107 pairs of matched liver
Cheng, Xiao-Ke +3 more
openaire +3 more sources
Indirect treatment comparison of dabrafenib plus trametinib versus vemurafenib plus cobimetinib in previously untreated metastatic melanoma patients. [PDF]
, 2017 BackgroundMetastatic melanoma is an aggressive form of skin cancer with a high mortality rate and the fastest growing global incidence rate of all malignancies.
Ahuja, Amit +4 more
core +2 more sources
Elevated Hippocampal Cholinergic Neurostimulating Peptide precursor protein (HCNP-pp) mRNA in the amygdala in major depression [PDF]
, 2015 The amygdala is innervated by the cholinergic system and is involved in major depressive disorder (MDD). Evidence suggests a hyper-activate cholinergic system in MDD.
Argibay, Pablo +3 more
core +1 more source
MAP kinase meets mitosis: A role for Raf Kinase Inhibitory Protein in spindle checkpoint regulation
Cell Division, 2007 Raf Kinase Inhibitory Protein (RKIP) is an evolutionarily conserved protein that functions as a modulator of signaling by the MAP kinase cascade.
Rosner Marsha
doaj +1 more source
Mechanism of regulation of Raf-1 by Ca2+/Calmodulin-dependent kinase II [PDF]
, 2011 The calcium-calmodulin dependent kinase II (CaMKII) is an ubiquitous serine/threonine protein kinase involved in multiple signalings and biological functions.
Salzano, Marcella
core +1 more source
Microgravity effect on expressionofRaf kinase inhibitor protein on MCF-7 breast cancer cell line [PDF]
مجله علمی دانشگاه علوم پزشکی کردستان, 2019 Background and Aim: The living organisms on the earth are under the influence of natural gravity force and if this gravitational force changes, they will be affected by a unique shock.
Maryam Salavatifar, Zahra Hajebrahimi
doaj +2 more sources
Journal of Lipid Research, 2013 Chronic exposure of skeletal muscle to saturated fatty acids, such as palmitate (C16:0), enhances proinflammatory IKK-NFκB signaling by a mechanism involving the MAP kinase (Raf-MEK-ERK) pathway. Raf activation can be induced by its dissociation from the
Katherine Macrae +7 more
doaj +1 more source
Differential proteomic profiling unveils new molecular mechanisms associated with mitochondrial complex III deficiency [PDF]
, 2015 We have analyzed the cellular pathways and metabolic adaptations that take place in primary skin fibroblasts from patients with mutations in BCS1L, a major genetic cause of mitochondrial complex III enzyme deficiency.
Arenas, Joaquín +10 more
core +2 more sources
GRK2 Constitutively Governs Peripheral Delta Opioid Receptor Activity
Cell Reports, 2016 Opioids remain the standard for analgesic care; however, adverse effects of systemic treatments contraindicate long-term administration. While most clinical opioids target mu opioid receptors (MOR), those that target the delta class (DOR) also ...
Allison Doyle Brackley +4 more
doaj +1 more source