Results 171 to 180 of about 3,058 (214)

Phosphatidylethanolamine‐Binding Proteins, Including RKIP, Exhibit Affinity for Phosphodiesterase‐5 Inhibitors

ChemBioChem, 2009
AbstractIdentifying protein “interactors” of drugs is of great importance to understand their mode of action and possible cross‐reactivity to off‐target protein binders. In this study, we profile proteins that bind to PF‐3717842, a high‐affinity phosphodiesterase‐5 (PDE5) inhibitor, by using a refined affinity pulldown approach with PF‐3717842 ...
Dadvar, P., Kovanich, D., Folkers, G.E., Rumpel, K., Raijmakers, R., Heck, A.J.R.   +5 more
openaire   +3 more sources

Survey of Raf Kinase Inhibitor Protein (RKIP) in Multiple Cancer Types

Critical Reviews in Oncogenesis, 2014
Raf kinase inhibitor protein (RKIP), an inhibitor of several signaling pathways, has been shown to have metastasis suppressor gene activity and promote apoptosis. While first identified in prostate cancer, RKIP's anti-metastasis properties have now been demonstrated in multiple tumor types.
Kelly, Lamiman, Jill M, Keller, Atsushi, Mizokami, Jian, Zhang, Evan T, Keller   +4 more
openaire   +2 more sources

RAF kinase inhibitory protein (RKIP) modulates cell cycle kinetics and motility

Mol. BioSyst., 2011
RKIP-1 is a metastasis suppressor that is frequently downregulated in aggressive cancers. However, the consequences of RKIP loss in primary or immortalized cells have not yet been explored. Using HEK-293 RKIP depleted (termed HEK-499) and Flp-In T-Rex-293 RKIP inducible cell lines combined with whole transcriptome analysis, we show that RKIP-1 ...
Fahd, al-Mulla, Milad S, Bitar, Zainab, Taqi, Oliver, Rath, Walter, Kolch   +4 more
openaire   +2 more sources

Raf kinase inhibitory protein (RKIP): A physiological regulator and future therapeutic target

Expert Opinion on Therapeutic Targets, 2008
Raf kinase inhibitory protein (RKIP) belongs to the phosphatidylethanolamine binding protein (PEBP) family that is expressed in both prokaryotic and euakaryotic organisms.In this review, we discuss the role of RKIP as a modulator of signal transduction, the relationship of RKIP to other members of the PEBP family, and the role of RKIP in human health ...
Lingchun, Zeng, Akira, Imamoto, Marsha Rich, Rosner   +2 more
openaire   +2 more sources

RAF-kinase inhibitor protein (RKIP) downregulation in esophageal cancer and its metastases

Clinical & Experimental Metastasis, 2012
Raf kinase inhibitor protein (RKIP) is an inhibitor of Raf-mediated activation of mitogen-activated protein (MAP) kinase (MEK)-MAP kinase and is considered as an important tumor suppressor. RKIP-expression was investigated retrospectively in 321 esophageal cancers [179 adenocarcinomas (ACs), 142 squamous cell carcinomas (SCCs)].
Peter, Birner, Bettina, Jesch, Andrea, Schultheis, Sebastian F, Schoppmann   +3 more
openaire   +2 more sources

The role of Raf kinase inhibitor protein (RKIP) in health and disease

Biochemical Pharmacology, 2004
Raf kinase inhibitor protein (RKIP) is a member of the phosphatidylethanolamine-binding protein (PEBP) family. RKIP plays a pivotal modulatory role in several protein kinase signaling cascades. RKIP binds inhibits Raf-1-mediated phosphorylation of MEK through binding to Raf-1.
Evan T, Keller, Zheng, Fu, Meghan, Brennan   +2 more
openaire   +2 more sources

Unique Pattern of Raf-1 Kinase Inhibitory Protein (RKIP) Expression in Multiple Myeloma (MM) Compared to Other Tumor Types: Overexpression of RKIP and a Phosphorylated RKIP Is Common in MM Tumor Cells.

Blood, 2007
Abstract Objective and Rationale Raf-1 kinase inhibitory protein (RKIP) is a modulator of cell signaling and survival that functions as an endogenous inhibitor of multiple kinases, including kinases involved in the Raf/MEK/ERK and NF-κB pathways.
Stavroula Baritaki, Sara Huerta-Yepez, Kam Yeung, Manuel Penichet, Haiming Chen, Dror Shalitin, James Berenson, Benjamin Bonavida   +7 more
openaire   +1 more source

Human Intestinal Raf Kinase Inhibitor Protein (RKIP) Catalyzes Prasugrel as a Bioactivation Hydrolase

Drug Metabolism and Disposition, 2016
Prasugrel is a thienopyridine antiplatelet prodrug that undergoes rapid hydrolysis in vivo to a thiolactone metabolite by human carboxylesterase-2 (hCE2) during gastrointestinal absorption. The thiolactone metabolite is further converted to a pharmacologically active metabolite by cytochrome P450 isoforms.
Miho, Kazui, Yuji, Ogura, Katsunobu, Hagihara, Kazuishi, Kubota, Atsushi, Kurihara   +4 more
openaire   +2 more sources

Metastasis suppressor genes: a role for raf kinase inhibitor protein (RKIP)

Anti-Cancer Drugs, 2004
The metastatic cascade is a complicated process that involves many steps from gain of the metastatic phenotype in the primary tumor cells through establishment of macroscopic tumor at the distant target organ. A group of genes, termed metastasis suppressor genes (MSG), encode for proteins that inhibit various steps of the metastatic cascade ...
openaire   +2 more sources

Identification of RKIP as an Invasion Suppressor Protein in Nasopharyngeal Carcinoma by Proteomic Analysis

Journal of Proteome Research, 2008
To identify novel proteins associated with the pathogenesis of nasopharyngeal carcinoma (NPC), a proteomic approach was used to screen for differential proteins between NPC and adjacent noncancerous nasopharyngeal epithelial tissue (ANNET). As a result, 21 differential proteins were identified by two-dimensional electrophoresis and mass spectrometer ...
Yan, Chen, Guo-Liang, Ouyang, Hong, Yi, Mao-Yu, Li, Peng-Fei, Zhang, Cui, Li, Jian-Ling, Li, Ying-Fu, Liu, Zhu-Chu, Chen, Zhi-Qiang, Xiao   +9 more
openaire   +2 more sources