Results 21 to 30 of about 3,058 (214)
Tzu Chi Medical Journal, 2021 Targeted therapy aiming at the metastatic signal pathway, such as that triggered by receptor tyrosine kinase (RTK), for the prevention of tumor progression is promising.
Chi-Tan Hu +2 more
doaj +1 more source
RKIP Inhibits Local Breast Cancer Invasion by Antagonizing the Transcriptional Activation of MMP13. [PDF]
PLoS ONE, 2015 Raf Kinase Inhibitory Protein or RKIP was initially identified as a Raf-1 binding protein using the yeast 2-hybrid screen. RKIP inhibits the activation phosphorylation of MEK by Raf-1 by competitively inhibiting the binding of MEK to Raf-1 and thus ...
Ila Datar +14 more
doaj +1 more source
Raf Kinase Inhibitory Protein (RKIP): Functional Pleiotropy in the Mammalian Brain [PDF]
Critical Reviews in Oncogenesis, 2014 In 1984, a cytosolic protein was isolated from bovine brain and coined phosphatidylethanolamine binding protein (PEBP) to describe its phospholipid-binding potential. Its cellular function remained elusive for more than a decade until it was discovered that PEBP had the ability to suppress the Raf1-mitogen activated protein kinase (MAPK) pathway ...
Harrod H, Ling +3 more
openaire +2 more sources
Role of pyroptosis in the pathogenesis and treatment of diseases
MedComm, Volume 4, Issue 3, June 2023., 2023 This review summarizes current insights into the complicated relationship between pyroptosis and multiple inflammatory diseases, such as cardiovascular diseases (CVDs), cancer, neurological diseases (NDs), and metabolic diseases (MDs). It also discusses a promising novel strategy and method for treating these inflammatory diseases by targeting ...
Xiangyu Jin +3 more
wiley +1 more source
Raf Kinase Inhibitor Protein RKIP Enhances Signaling by Glycogen Synthase Kinase-3β [PDF]
Cancer Research, 2011 Abstract Raf kinase inhibitory protein (RKIP) is a physiologic inhibitor of c-RAF kinase and nuclear factor κB signaling that represses tumor invasion and metastasis. Glycogen synthase kinase-3β (GSK3β) suppresses tumor progression by downregulating multiple oncogenic pathways including Wnt signaling and cyclin D1 activation. Here, we
Al-Mulla, Fahd +9 more
openaire +3 more sources
Mediators of Inflammation, Volume 2023, Issue 1, 2023., 2023 Gastric cancer (GC) is one of the most common and lethal cancers worldwide. In view of the prominent roles of long noncoding RNAs (lncRNAs) in cancers, we investigated the specific role and underlying mechanism of GATA binding protein 6 antisense RNA 1 (GATA6‐AS1) in GC.
Yi Jin, Daqing Jiang, Jinghua Pan
wiley +1 more source
Estimating Network Kinetics of the MAPK/ERK Pathway Using Biochemical Data [PDF]
, 2012 The MAPK/ERK pathway is a major signal transduction system which regulates many fundamental cellular processes including the growth control and the cell death.
Purutçuoğlu, Vilda,, Wit, Ernst,
core +11 more sources
Molecular and cellular paradigms of multidrug resistance in cancer
Cancer Reports, Volume 5, Issue 12, December 2022., 2022 Abstract Background The acquisition of resistance to chemotherapy is a major hurdle in the successful application of cancer therapy. Several anticancer approaches, including chemotherapies, radiotherapy, surgery and targeted therapies are being employed for the treatment of cancer.
Foram U. Vaidya +6 more
wiley +1 more source
Frontiers in Molecular Biosciences, 2021 Protein-protein interactions are indispensable physiological processes regulating several biological functions. Despite the availability of structural information on protein-protein complexes, deciphering their complex topology remains an outstanding ...
Shraddha Parate +4 more
doaj +1 more source
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP [PDF]
, 1999 Raf-1 phosphorylates and activates MEK-1, a kinase that activates the extracellular signal regulated kinases (ERK). This kinase cascade controls the proliferation and differentiation of different cell types.
A Minden +25 more
core +1 more source