Results 31 to 40 of about 3,058 (214)

Therapeutic gas‐releasing nanomedicines with controlled release: Advances and perspectives

Exploration, Volume 2, Issue 5, October 2022., 2022
This review takes a critical look at four key gasotransmitters (CO, NO, H2S and SO2) with their incorporation into prodrugs known as gas‐releasing molecule. Different nanosystems and their mediatory roles for efficient shuttling, targeting and cleavage of therapeutic gases and the responsiveness to typical internal and external stimuli for gas release ...
Yaw Opoku‐Damoah, Run Zhang, Hang T. Ta, Zhi Ping Xu   +3 more
wiley   +1 more source

Analysis of signalling pathways using continuous time Markov chains [PDF]

, 2006
We describe a quantitative modelling and analysis approach for signal transduction networks. We illustrate the approach with an example, the RKIP inhibited ERK pathway [CSK+03].
A. Aziz, B. Schoeberl, B.N. Kholodenko, C. Priami, D. Gillespie, E.O. Voit, H. Matsuno, J.W. Pinney, K.-H. Cho, L. Popova-Zeugmann, M. Kwiatkowska, N. Chabrier, N. Chabrier-Rivier   +12 more
core   +3 more sources

Transcription factor YY1 contributes to human melanoma cell growth through modulating the p53 signalling pathway

Experimental Dermatology, Volume 31, Issue 10, Page 1563-1578, October 2022., 2022
Abstract Melanoma has a higher mortality rate than any other skin cancer, and its cases are increasing. The transcription factor YY1 has been proven to be involved in tumour progression; however, the role of YY1 in melanoma is not well understood. This study investigates how YY1 functions in melanoma progression, and it also elucidates the underlying ...
Shumin Zhou, Pin Li, Li Qin, Shuhong Huang, Ningning Dang   +4 more
wiley   +1 more source

Sensitization of the Angiotensin II AT1 Receptor Contributes to RKIP-Induced Symptoms of Heart Failure

Frontiers in Medicine, 2019
Inhibition of the G-protein-coupled receptor kinase 2 (GRK2) is an emerging treatment approach for heart failure. Therefore, cardio-protective mechanisms induced by GRK2 inhibition are under investigation. We compared two different GRK2 inhibitors, i.e.,
Stefan Wolf, Joshua Abd Alla, Ursula Quitterer, Ursula Quitterer   +3 more
doaj   +1 more source

Computational models for inferring biochemical networks [PDF]

, 2014
Biochemical networks are of great practical importance. The interaction of biological compounds in cells has been enforced to a proper understanding by the numerous bioinformatics projects, which contributed to a vast amount of biological information ...
Crina Grosan, D Voet, David Gilbert, E Aarts, G Fogel, I Swameye, J Kitagawa, JT Heaton, K Yeung, K Yeung, M Heiner, M Oltean, M Oltean, Ovidiu Parvu, R Breitling, Ramona Stoica, S Kirkpatrick, Silvia Rausanu, U Klingmueller, W Elliot, Zujian Wu   +20 more
core   +1 more source

Raf kinase inhibitory protein reduces bradykinin receptor desensitization

Journal of Neurochemistry, Volume 162, Issue 2, Page 156-165, July 2022., 2022
In this study, we investigated unknown biochemical modulators that may contribute to persistent inflammation. We identified that small, physiological concentrations of bradykinin can stimulate protein kinase C (PKC) activity, to increase phosphorylation of Raf Kinase Inhibitory Protein (RKIP) and its association with GPCR Receptor Kinase 2 (GRK2 ...
Samuel B. Chivers, Allison Doyle Brackley, Nathaniel A. Jeske   +2 more
wiley   +1 more source

Expression of phosphorylated raf kinase inhibitor protein (pRKIP) is a predictor of lung cancer survival

BMC Cancer, 2011
Background Raf-1 kinase inhibitor protein (RKIP) has been reported to negatively regulate signal kinases of major survival pathways. RKIP activity is modulated in part by phosphorylation on Serine 153 by protein kinase C, which leads to dissociation of ...
Chia David, Horvath Steve, Vega Mario I, Maresh Erin L, Chatterjee Devasis, Rivera-Pazos Clara M, Mah Vei, Hernandez-Cueto Angeles, Yoon Nam K, Huerta-Yepez Sara, Bonavida Benjamin, Goodglick Lee   +11 more
doaj   +1 more source

An integrative top-down and bottom-up qualitative model construction framework for exploration of biochemical systems [PDF]

, 2014
The authors would like to thank the support on this research by the CRISP project (Combinatorial Responses In Stress Pathways) funded by the BBSRC (BB/F00513X/1) under the Systems Approaches to Biological Research (SABR) Initiative.Peer ...
Coghill, George M, Pang, Wei, Wu, Zujian
core   +2 more sources

Relationship Between RKIP Protein Expression and Clinical Staging in Thyroid Carcinoma [PDF]

The Open Endocrinology Journal, 2008
Raf-1 Kinase Inhibitory Protein (RKIP) belongs to a new class modulators of signalling cascades involved in maintaining of biological balance in many living organisms. RKIP targets and inhibits different kinases (Mitogen Activated Protein (MAP) kinase, G- protein coupled receptor (GPCR) kinase and nuclear factor kappa B (NF- B) signaling pathways), and
Bogusz Trojanowicz, Ting Fu, Oliver Gimm, Carsten Sekulla, Rainer Finke, Henning Dralle, Cuong Hoang-Vu   +6 more
openaire   +1 more source

[Retracted] LRSAM1 E3 Ubiquitin Ligase Promotes Choriocarcinoma Progression and Metastasis via p53/p21 Signaling Impediment

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
Objective. The E3 ubiquitin ligase LRSAM1 (LRSAM1) was involved in many cancers, but whether it exerts anti‐ or protumor efficacies on choriocarcinoma cellular structures remains unknown. We wanted to explore the efficacies of aberrant LRSAM1 expression on human choriocarcinoma cellular structures and the underlying mechanisms. Methods.
Qiumin Li, Ying Wang, Feifei Liu, Haili Wang, Yangyang Fan, Zhijun Liao   +5 more
wiley   +1 more source