Results 41 to 50 of about 3,058 (214)

Intermediates and Generic Convergence to Equilibria [PDF]

, 2017
Known graphical conditions for the generic or global convergence to equilibria of the dynamical system arising from a reaction network are shown to be invariant under the so-called successive removal of intermediates, a systematic procedure to simplify ...
de Freitas, Michael Marcondes, Feliu, Elisenda, Wiuf, Carsten   +2 more
core   +2 more sources

Epigenetic changes and nuclear factor-\u3baB activation, but not microRNA-224, downregulate Raf-1 kinase inhibitor protein in triple\u2011negative breast cancer SUM 159 cells [PDF]

, 2015
Raf-1 kinase inhibitor protein (RKIP) is a tumor suppressor and metastasis inhibitor, which enhances drug\u2011induced apoptosis of cancer cells. Downregulation of RKIP may be significant in the biology of highly aggressive and drug\u2011resistant tumors,
D'Alessandro, N., Gulino, A., Labbozzetta, M., NOTARBARTOLO DI VILLAROSA, M., Poma, P., Vivona, N.   +5 more
core   +1 more source

Modelling the influence of RKIP on the ERK signalling pathway using the stochastic process algebra PEPA [PDF]

, 2006
This paper examines the influence of the Raf Kinase Inhibitor Protein (RKIP) on the Extracellular signal Regulated Kinase (ERK) signalling pathway [5] through modelling in a Markovian process algebra, PEPA [11].
A. Aziz, A. Regev, C. Priami, C.A. Vissers, J. Fisher, J. Hillston, J.A. Papin, J.M. Colom, K.-H. Cho, M. Kwiatkowska, S. Gilmore, T.H. Matheiss, W. Stewart, W.H. Elliot   +13 more
core   +3 more sources

A new model for raf kinase inhibitory protein induced chemotherapeutic resistance. [PDF]

PLoS ONE, 2012
Therapeutic resistance remains the most challenging aspect of treating cancer. Raf kinase inhibitory protein (RKIP) emerged as a molecule capable of sensitizing cancerous cells to radio- and chemotherapy.
Fahd Al-Mulla, Milad S Bitar, Jingwei Feng, Sungdae Park, Kam C Yeung   +4 more
doaj   +1 more source

cis-Acting elements and trans-acting factors in the transcriptional regulation of raf kinase inhibitory protein expression. [PDF]

PLoS ONE, 2013
The Raf kinase inhibitory protein (RKIP) is down-regulated in multiple types of human cancers. Decreased RKIP transcription activity may be one of the major mechanisms responsible for the downregulation of RKIP expression in human diseases.
Boyan Zhang, Ou Wang, Jingchao Qin, Shuaishuai Liu, Sheng Sun, Huitu Liu, Jian Kuang, Guohua Jiang, Wei Zhang   +8 more
doaj   +1 more source

Model reduction and process analysis of biological models [PDF]

, 2015
International audienceUnderstanding the dynamical behavior of biological networks is complicated due to their large number of components and interactions.
Casagranda, Stefano, Gouzé, Jean-Luc, Ropers, Delphine   +2 more
core   +3 more sources

Downregulation of RKIP is associated with poor outcome and malignant progression in gliomas.

PLoS ONE, 2012
Malignant gliomas are highly infiltrative and invasive tumors, which precludes the few treatment options available. Therefore, there is an urgent need to elucidate the molecular mechanisms underlying gliomas aggressive phenotype and poor prognosis.
Olga Martinho, Sara Granja, Teresa Jaraquemada, Cláudia Caeiro, Vera Miranda-Gonçalves, Mrinalini Honavar, Paulo Costa, Margarida Damasceno, Marsha R Rosner, José M Lopes, Rui M Reis   +10 more
doaj   +1 more source

An Integrated Qualitative and Quantitative Biochemical Model Learning Framework Using Evolutionary Strategy and Simulated Annealing [PDF]

, 2015
The authors would like to thank the support on this research by the CRISP Project (Combinatorial Responses In Stress Pathways) funded by the BBSRC (BB/F00513X/1) under the Systems Approaches to Biological Research (SABR) Initiative.Peer reviewedPublisher
A Hinton, A Kremling, A Nobakhti, AC Cem, AF Villaverde, B Kuipers, B Kuipers, B Kuipers, BN Kholodenko, C Chaouiya, CG Moles, D Gilbert, D Lee, DT Hau, George M. Coghill, GM Coghill, H Beyer, H Feng, H Matsuno, I Habibi, J Peil, K Yeung, KH Cho, L Brim, L Ljung, L Michaelis, L Napione, LJ Steggles, M Heiner, M Peleg, MO Vlad, N Metropolis, OE Akman, P Baldan, P Baldan, P Gormley, R Breitling, R Samaga, RD King, S Anily, S Kirkpatrick, T Murata, T Qin, V Chelliah, VN Reddy, W Marwan, W Pang, W Pang, W Pang, W Pang, W Pang, Wei Pang, WH Elliot, Z Wu, Z Wu, Zujian Wu   +55 more
core   +1 more source

Stronger computational modelling of signalling pathways using both continuous and discrete-state methods [PDF]

, 2006
Starting from a biochemical signalling pathway model expresses in a process algebra enriched with quantitative information, we automatically derive both continuous-space and discrete-space representations suitable for numerical evaluation.
A. Aziz, A. Chatterjee, B. Schoeberl, C. Priami, D. Gillespie, D.T. Gillespie, D.T. Gillespie, F.H. Chi-Ying, J. Hillston, J. Hillston, J. Hillston, K.-H. Cho, L.F. Shampine, M. Buchholtz, M. Kwiatkowska, M. Rathinam, O. Wolkenhauer, S. Ramsey, T.E. Turner, Y. Cao   +19 more
core   +5 more sources

Raf Kinase Inhibitory Protein (RKIP) as a Metastasis Suppressor: Regulation of Signaling Networks in Cancer [PDF]

Critical Reviews in Oncogenesis, 2014
Cancer is one of the deadliest diseases worldwide, accounting for about 8 million deaths a year. For solid tumors, cancer patients die as a result of the metastatic spread of the tumor to the rest of the body. Therefore, there is a clinical need for understanding the molecular and cellular basis of metastasis, identifying patients whose tumors are more
Ali E, Yesilkanal, Marsha Rich, Rosner
openaire   +2 more sources