Results 51 to 60 of about 3,058 (214)

A New p53 Target Gene, RKIP, Is Essential for DNA Damage-Induced Cellular Senescence and Suppression of ERK Activation

Neoplasia: An International Journal for Oncology Research, 2013
p53, a strong tumor suppressor protein, is known to be involved in cellular senescence, particularly premature cellular senescence. Oncogenic stresses, such as Ras activation, can initiate p53-mediated senescence, whereas activation of the Ras-mitogen ...
Su-Jin Lee, Sun-Hye Lee, Min-Ho Yoon, Bum-Joon Park   +3 more
doaj   +1 more source

Common reduction of the Raf kinase inhibitory protein in clear cell renal cell carcinoma [PDF]

, 2014
Despite the recent progress in our understanding of clear cell renal cell carcinomas (ccRCCs), the etiology of ccRCC remains unclear. We reported here a prevailing reduction of the raf kinase inhibitory protein (RKIP) in ccRCC. In our examination of more
Bakhtyar, Nazihah, Cutz, Jean-Claude, Feng, Xingchang, He, Lizhi, Hill, Brianne, Kapoor, Anil, Melo, Jason De, Tang, Damu, Yan, Judy   +8 more
core   +1 more source

Expression and Significance of Raf Kinase Inhibitory Protein 
in Lung Cancer

Chinese Journal of Lung Cancer, 2012
Background and objective Raf kinase inhibitory protein (RKIP) belongs to the phosphatidylethanolamine binding protein family. RKIP is an endogenous inhibitor of the ERK/MAPK, NF-κΒ, and G protein-coupled receptor signaling pathways.
Dayun YANG, Zhan QI
doaj   +1 more source

The RhoA dependent anti-metastatic function of RKIP in breast cancer

Scientific Reports, 2021
Raf-1 kinase inhibitor protein was initially discovered as a physiological kinase inhibitor of the MAPK signaling pathway and was later shown to suppress cancer cell invasion and metastasis.
Gardiyawasam Kalpana, Christopher Figy, Jingwei Feng, Claire Tipton, Julius N. De Castro, Vu N. Bach, Clariza Borile, Alexandria LaSalla, Hussain N. Odeh, Miranda Yeung, Rafael Garcia-Mata, Kam C. Yeung   +11 more
doaj   +1 more source

An introduction to Biomodel engineering, illustrated for signal transduction pathways [PDF]

, 2009
BioModel Engineering is the science of designing, constructing and analyzing computational models of biological systems. It is inspired by concepts from software engineering and computing science.
Breitling, R, Donaldson, R, Gilbert, D, Heiner, M   +3 more
core   +1 more source

Genetic variants in RKIP are associated with clear cell renal cell carcinoma risk in a Chinese population. [PDF]

PLoS ONE, 2014
BACKGROUND: Raf-1 kinase inhibitor protein (RKIP) plays a critical role in tumor development by regulating cell functions such as invasion, apoptosis and differentiation.
Qiang Cao, Jian Wang, Mingcong Zhang, Pu Li, Jian Qian, Shaobo Zhang, Lei Zhang, Xiaobing Ju, Meilin Wang, Zhengdong Zhang, Jie Li, Min Gu, Wei Zhang, Chao Qin, Pengfei Shao, Changjun Yin   +15 more
doaj   +1 more source

a retrospective cohort study [PDF]

, 2015
Background Metastasis of colorectal cancer (CRC) is directly linked to patient survival. We previously identified the novel gene Metastasis Associated in Colon Cancer 1 (MACC1) in CRC and demonstrated its importance as metastasis inducer and prognostic ...
Herrmann, Pia, Karamitopoulou, Eva, Koelzer, Viktor H., Lugli, Alessandro, Stein, Ulrike, Zlobec, Inti   +5 more
core   +1 more source

Metastasis suppressor gene Raf kinase inhibitor protein (RKIP) is a novel prognostic marker in prostate cancer [PDF]

The Prostate, 2006
Diminished expression of Raf kinase inhibitor protein (RKIP), an inhibitor of the Raf signaling cascade, promotes prostate cancer (PCa) metastasis in a murine model, suggesting that it is a metastasis suppressor gene. However, the prognostic significance of RKIP expression and its association with metastasis in PCa patients is unknown.To investigate ...
Fu, Zheng, Kitagawa, Yasuhide, Shen, Ronglai, Shah, Rajal B, Mehra, Rohit, Rhodes, Daniel R., Keller, Peter J., Mizokami, Atsushi, Dunn, Rodney L., Chinnaiyan, Arul M., Yao, Zhi, Keller, Evan T.   +11 more
openaire   +3 more sources

Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients [PDF]

, 2013
Gastric cancer is a leading cause of cancer-related mortality, and the presence of lymph node metastasis an important prognostic factor. Downregulation of RKIP has been associated with tumor progression and metastasis in several types of neoplasms, being
ADHEMAR LONGATTO-FILHO, Akaishi, Al-Mulla, Al-Mulla, Baritaki, Baritaki, Bernier, Bonavida, BRUNO ZILBERSTEIN, CARLOS EDUARDO JACOB, Chatterjee, Chatterjee, Chen, CLÁUDIO BRESCIANI, Crew, Desai, Dicken, Fenoglio-Preiser, Fu, Fu, Gabbert, Granovsky, Greene, Hagan, Hori, Houben, IVAN CECCONELLO, Jazirehi, Jia, JOAQUIM GAMA-RODRIGUES, KLEBER SIMÕES, Klysik, Lauren, Lee, Li, Lorenz, Martinho, Martinho, Martinho, Milne, Ming, Minoo, Minoo, OLGA MARTINHO, Pinheiro, RUI MANUEL REIS, Schuierer, Schuierer, Seddiqi, Utsunomiya, Vauhkonen, VENÂNCIO ALVES, Wang, Washington, Yeung, Yeung, Yeung, Yonemura, Zaravinos, Zhang, Zlobec   +60 more
core   +1 more source

Mycobacterium tuberculosis Raf kinase inhibitor protein (RKIP) Rv2140c is involved in cell wall arabinogalactan biosynthesis via phosphorylation

Microbiological Research, 2021
Mycobacterium tuberculosis Rv2140c is a function unknown conserved phosphatidylethanolamine-binding protein (PEBP), homologous to Raf kinase inhibitor protein (RKIP) in human beings. To delineate its function, we heterologously expressed Rv2140c in a non-pathogenic M. smegmatis.
M A, Abo-Kadoum, Mohammed, Assad, Yongdong, Dai, Nzungize, Lambert, Ulrich Aymard Ekomi, Moure, Adel, Eltoukhy, Stech A E, Nzaou, Asmaa, Moaaz, Jianping, Xie   +8 more
openaire   +2 more sources