Results 61 to 70 of about 3,058 (214)

Bmi-1-induced miR-27a and miR-155 promote tumor metastasis and chemoresistance by targeting RKIP in gastric cancer

Molecular Cancer, 2020
Background We previously reported an inverse relationship between B cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) and Raf kinase inhibitory protein (RKIP), which is associated with the prognosis of gastric cancer (GC).
Yaqing Li, Zhenfeng Tian, Ying Tan, Guoda Lian, Shangxiang Chen, Shaojie Chen, Jiajia Li, Xuanna Li, Kaihong Huang, Yinting Chen   +9 more
doaj   +1 more source

Ybcl of uropathogenic escherichia coli suppresses transepithelial neutrophil migration [PDF]

, 2012
Uropathogenic Escherichia coli (UPEC) strains suppress the acute inflammatory response in the urinary tract to ensure access to the intracellular uroepithelial niche that supports the propagation of infection. Our understanding of this initial cross talk
Hunstad, David A, Lau, Megan E, Loughman, Jennifer A   +2 more
core   +2 more sources

Abstracts

, 2023
Molecular Oncology, Volume 17, Issue S1, Page 1-597, June 2023.
wiley   +1 more source

Prognostic value of RKIP and p-ERK in gastric cancer

Journal of Experimental & Clinical Cancer Research, 2012
Background The mitogen-activated protein kinase (MAPK) signaling pathway participates in several steps of tumour development and is considered a prominent therapeutic target for the design of chemotherapeutic agents.
Fujimori Yoshitaka, Inokuchi Mikito, Takagi Yoko, Kato Keiji, Kojima Kazuyuki, Sugihara Kenichi   +5 more
doaj   +1 more source

Approximations and their consequences for dynamic modelling of signal transduction pathways [PDF]

, 2007
Signal transduction is the process by which the cell converts one kind of signal or stimulus into another. This involves a sequence of biochemical reactions, carried out by proteins.
Asthagiri, Atkins, Blüthgen, Briggs, Brightmann, Chen, Cho, Cornish-Bowden, Crampin, De Jong, Downward, Eissing, Eric Bullinger, Fell, Ferrell, Ferrell, Ferrell, Fowler, Goldbeter, Goldbeter, Hatakeyama, Heinrich, Heinrich, Huang, Johann Rohwer, Kholodenko, Kholodenko, Laurent, Lewis, Llórens, Markevich, Mathews, Michaelis, Novak, Olaf Wolkenhauer, Rubinow, Schilling, Schnell, Schoeberl, Segel, Swameye, Thomas Millat, Timmer, Tyson, Tzafriri, Winfree, Wolkenhauer, Wolkenhauer, Wolkenhauer, Yeung   +49 more
core   +1 more source

The Multifaceted Roles of BACH1 in Disease: Implications for Biological Functions and Therapeutic Applications

Advanced Science, Volume 12, Issue 10, March 13, 2025.
BACH1, a basic leucine zipper protein ubiquitously expressed in mammalian tissues, plays a critical role in the regulation of oxidative stress, cell cycle progression, heme homeostasis, and immune responses. It is implicated in cardiovascular diseases, cancer progression, neurodegenerative disorders, and many other diseases.
Xiangxiang Wei, Yunquan He, Yueyang Yu, Sichong Tang, Ruiwen Liu, Jieyu Guo, Qingjun Jiang, Xiuling Zhi, Xinhong Wang, Dan Meng   +9 more
wiley   +1 more source

Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis

Haematologica, 2020
RAS-signaling mutations induce the myelomonocytic differentiation and proliferation of hematopoietic stem and progenitor cells. Moreover, they are important players in the development of myeloid neoplasias.
Veronica Caraffini, Olivia Geiger, Angelika Rosenberger, Stefan Hatzl, Bianca Perfler, Johannes L. Berg, Clarice Lim, Herbert Strobl, Karl Kashofer, Silvia Schauer, Christine Beham-Schmid, Gerald Hoefler, Klaus Geissler, Franz Quehenberger, Walter Kolch, Dimitris Athineos, Karen Blyth, Albert Wölfler, Heinz Sill, Armin Zebisch   +19 more
doaj   +1 more source

G protein-coupled receptor kinase 2 (GRK2) as a potential therapeutic target in cardiovascular and metabolic diseases [PDF]

, 2019
G protein-coupled receptor kinase 2 (GRK2) is a central signaling node involved in the modulation of many G protein-coupled receptors (GPCRs) and also displaying regulatory functions in other cell signaling routes.
Arcones, Alba C., Briones, Ana M., Cruces-Sande, Marta, Mayor, Federico, Murga, Cristina, Salaices, Mercedes   +5 more
core   +3 more sources

Increased Expression of miR-23a Mediates a Loss of Expression in the RAF Kinase Inhibitor Protein RKIP [PDF]

Cancer Research, 2016
Abstract RAF kinase inhibitor protein (RKIP) is a seminal regulator of intracellular signaling and exhibits both antimetastatic and antitumorigenic properties. Decreased expression of RKIP has been described in several human malignancies, including acute myelogenous leukemia (AML).
Hatzl, S., Geiger, O., Kuepper, M.K., Caraffini, V., Seime, T., Furlan, T., Nussbaumer, E., Wieser, R., Pichler, M., Scheideler, M., Nowek, K., Lavrencic, M., Quenhenberger, F., Wölfler, A., Troppmair, J., Sill, H., Zebisch, A.   +16 more
openaire   +5 more sources

Raf Kinase Inhibitor Protein Attenuates Ischemic-Induced Microglia Cell Apoptosis and Activation Through NF-κB Pathway

Cellular Physiology and Biochemistry, 2017
Background: Acute ischemic stroke is one of the most important factors leading to disability and death with the characterization of accumulated neuron death and injured supportive neurovascular structures.
Li Su, Rongrong Zhang, Yuanyuan Chen, Zhenyu Zhu, Chao Ma   +4 more
doaj   +1 more source