Results 81 to 90 of about 3,058 (214)

Raf-1 Kinase Inhibitory Protein (RKIP) Mediates Ethanol-induced Sensitization of Secretagogue Signaling in Pancreatic Acinar Cells [PDF]

Journal of Biological Chemistry, 2012
Excessive alcohol consumption is associated with most cases of chronic pancreatitis, a progressive necrotizing inflammatory disease that can result in pancreatic insufficiency due to acinar atrophy and fibrosis and an increased risk of pancreatic cancer.
Sung Ok, Kim, Kirk L, Ives, Xiaofu, Wang, Robert A, Davey, Celia, Chao, Mark R, Hellmich   +5 more
openaire   +2 more sources

Merkel Cell Polyomavirus—Pathophysiology and Treatment in the Era of Gene‐Targeted Therapies

Reviews in Medical Virology, Volume 34, Issue 5, September 2024.
ABSTRACT Merkel cell polyomavirus (MCPyV) is a significant contributor to the development of Merkel cell carcinoma (MCC), an aggressive skin cancer with high recurrence and a low survival rate. In fact, it is the deadliest skin cancer. The precise routes of transmission for MCPyV‐positive MCC remain unclear, but several factors may trigger its ...
Trairong Chokwassanasakulkit, Nigel A. J. McMillan   +1 more
wiley   +1 more source

Survival of metastatic melanoma patients after dendritic cell vaccination correlates with expression of leukocyte phosphatidylethanolamine-binding protein 1/Raf kinase inhibitory protein [PDF]

, 2017
Immunotherapy for metastatic melanoma offers great promise but, to date, only a subset of patients have responded. There is an urgent need to identify ways of allocating patients to the most beneficial therapy, to increase survival and decrease therapy ...
Austyn, J.M. (Jonathan), Baban, D. (Dilair), Beltrame, L. (Luca), Buschow, S.I. (Sonja I.), Cavalieri, D. (Duccio), Ellebaek, E. (Eva), Figdor, C.G. (Carl), Gross, S. (Stefanie), Hato, S.V. (Stanleyson V.), Heinzerling, L. (L.), Nguyen, V.A. (Van Anh), Ragoussis, J. (Jiannis), Ramazzotti, M. (Matteo), Reinieren-Beeren, I. (Inge), Romani, N. (Nikolaus), Schuler, G. (Gerhard), Schuler-Thurner, B. (Beatrice), Stefanini, I. (Irene), Svane, I.M. (Inge M.), Vries, I.J.M. (Jolanda) de, Weinlich, G. (Georg), Westdorp, H. (Harm)   +21 more
core   +1 more source

Immune‐mediated disruption of the blood–brain barrier after intracerebral hemorrhage: Insights and potential therapeutic targets

CNS Neuroscience &Therapeutics, Volume 30, Issue 7, July 2024.
Blood–brain barrier disruption and immune system infiltration after intracerebral hemorrhage. Abstract Aims Intracerebral hemorrhage (ICH) is a condition that arises due to the rupture of cerebral blood vessels, leading to the flow of blood into the brain tissue.
Peijun Jia, Qinfeng Peng, Xiaochong Fan, Yumeng Zhang, Hanxiao Xu, Jiaxin Li, Houn Sonita, Simon Liu, Anh Le, Qiongqiong Hu, Ting Zhao, Shijie Zhang, Junmin Wang, Marietta Zille, Chao Jiang, Xuemei Chen, Jian Wang   +16 more
wiley   +1 more source

MiR-543 Promotes Proliferation and Epithelial-Mesenchymal Transition in Prostate Cancer via Targeting RKIP

Cellular Physiology and Biochemistry, 2017
Background/Aims: MicroRNAs (miRNAs, miRs) have emerged as important post-transcriptional regulators in various cancers. miR-543 has been reported to play critical roles in hepatocellular carcinoma and colorectal cancer, however, the role of miR-543 in ...
Yang Du, Xiu-heng Liu, Heng-cheng Zhu, Lei Wang, Jin-zhuo Ning, Cheng-cheng Xiao   +5 more
doaj   +1 more source

ERK Signals: Scaffolding Scaffolds? [PDF]

, 2016
ERK1/2 MAP Kinases become activated in response to multiple intra- and extra-cellular stimuli through a signaling module composed of sequential tiers of cytoplasmic kinases. Scaffold proteins regulate ERK signals by connecting the different components of
Casar, Berta, Crespo, Piero
core   +2 more sources

Cyclin‐dependent kinase 5 (CDK5) inhibitors in Parkinson disease

Journal of Cellular and Molecular Medicine, Volume 28, Issue 11, June 2024.
Abstract Cyclin‐dependent kinase 5 (Cdk5) is a protein expressed in postmitotic neurons in the central nervous system (CNS). Cdk5 is activated by p35 and p39 which are neuron regulatory subunits. Cdk5/p35 complex is activated by calpain protease to form Cdk5/p35 which has a neuroprotective effect by regulating the synaptic plasticity and memory ...
Mohammed Alrouji, Haydar M. Al‐kuraishy, Ali I. Al‐Gareeb, Mohammed S. Alshammari, Athanasios Alexiou, Marios Papadakis, Mostafa M. Bahaa, Gaber El‐Saber Batiha   +7 more
wiley   +1 more source

Proteomic profiling of 13 paired ductal infiltrating breast carcinomas and non-tumoral adjacent counterparts. [PDF]

, 2007
According to recent statistics, breast cancer remains one of the leading causes of death among women in Western countries. Breast cancer is a complex and heterogeneous disease, presently classified into several subtypes according to their cellular origin.
Albanese, N., Cancemi, P., DI CARA, G., Marabeti, M., Marrazzo, A., PUCCI MINAFRA, I., Taormina, P.   +6 more
core   +1 more source

Overexpression of Raf Kinase Inhibitor Protein (RKIP) in Multiple Myeloma and Its Molecular Signature

Blood, 2016
Abstract Multiple myeloma (MM) is a clonal plasma-cell neoplastic disorder arising from an indolent premalignant disease known as monoclonal gammopathy of undetermined significance (MGUS) that can evolve to asymptomatic pre-MM and later to symptomatic MM.
Anna Shvartsur, Hermes Garban, Benjamin Bonavida   +2 more
openaire   +1 more source

Data from Raf Kinase Inhibitor Protein RKIP Enhances Signaling by Glycogen Synthase Kinase-3β

, 2023
<div>Abstract<p>Raf kinase inhibitory protein (RKIP) is a physiologic inhibitor of c-RAF kinase and nuclear factor κB signaling that represses tumor invasion and metastasis. Glycogen synthase kinase-3β (GSK3β) suppresses tumor progression by downregulating multiple oncogenic pathways including Wnt signaling and cyclin D1 activation.
Walter Kolch, Andrew Pitt, Kit Yee Tan, Brendan Doyle, Oliver Rath, Waleed Al-Ali, Abdulla I. Behbehani, May Al-Maghrebi, Milad S. Bitar, Fahd Al-Mulla   +9 more
openaire   +1 more source