Rational Design for High Bioorthogonal Fluorogenicity of Tetrazine-Encoded Green Fluorescent Proteins. [PDF]
Nat Sci (Weinh), 2022 Targeted mutagenesis aided by ultrafast molecular spectroscopic insights into the tetrazine‐encoded green fluorescent proteins in action in physiologically relevant environments has effectively achieved the record‐high bioorthogonal fluorogenicity to date for next‐generation bioimaging and life science advances.
Tang L +5 more
europepmc +2 more sources
A Study on the Potential of Valorizing Sargassum latifolium into Biofuels and Sustainable Value-Added Products. [PDF]
Int J BiomaterTo increase the limited commercial utility and lessen the negative environmental effects of the massive growth of brown macroalgae, this work illustrates the feasibility of valorizing the invasively proliferated Sargassum latifolium into different value‐added products.
El-Gendy NS +8 more
europepmc +2 more sources
Exploring Cheminformatic Toolsets for Predicting the Dermal Toxicity of Furanocoumarins [PDF]
, 2021 Linear furanocoumarins are skin sensitizers and anticancer agents whose appeal in skincare therapeutics is widely exploited. Owing to the need to predict the biological activities of medicines, this work aimed the investigate the predicted dermal ...
Couto, Rene Oliveira do +4 more
core +2 more sources
Фармакотерапевтичний ефект стреспротекторів у віковому аспекті [PDF]
, 2017 The data of the literature and the results of original experimental observations concerning the age aspects of stress reactions that accompany a person from birth to adulthood are given. Stress in children is emotional and is characterized by an increase
Hladkykh, Fedir +3 more
core +6 more sources
A brief overview of current drug repurposing approaches for COVID-19 management [PDF]
, 2020 This brief overview is intended to shed light on the current drug repositioning (also called drug repurposing) in the therapeutics of the novel coronavirus disease which emerged in 2019 (COVID-19).
Rodrigues, Pedro da Fonseca Soares +1 more
core +2 more sources
Мультимодальная анальгезия: полипрагмазия в обезболивании или рациональное применение нестероидных противовоспалительных средств для предотвращения хронизации боли [PDF]
, 2020 Pain is the psychophysiological reaction of an entire organism to a damaging factor. According to the literature, 30.0–75.0 % of patients suffer from severe pain in the postoperative period.
Hladkykh, Fedir
core +2 more sources
Фармакопрофілактичні та фармакотерапевтичні підходи до послаблення пошкоджуючої дії іонізуючого опромінення: огляд інформаційних джерел [PDF]
, 2018 The purpose of the article is to synthesize the scientific points of view on modern approaches to pharmacological correction of radiation damage. Conducting medical treatment, aimed at eliminating the negative effects of exposure to ionizing radiation ...
Hladkykh, Fedir
core +2 more sources
Investigation of Cyclobenzaprine Interactions with P450 Cytochromes CYP1A2 and CYP3A4 through Molecular Docking Tools [PDF]
, 2019 Cyclobenzaprine (CBP) is a centrally acting muscle relaxant whose myriad of therapeutic applications imply the need of better understanding its pharmacokinetics and thermodynamics.
Douglas Vieira Thomaz +3 more
core +2 more sources
Chemoinformatic Approaches in the Study of Fluralaner and Afoxolaner-mediated Inhibition of l-glutamate-gated Chloride Channels [PDF]
, 2019 This work showcased the chemoinformatic study of isoxazoline ectoparasiticides: Fluralaner (FLU) and Afoxolaner (AFO) interactions with l-glutamate-gated chloride channels (3RHW).
Douglas Vieira Thomaz +2 more
core +2 more sources
Predictive Modelling to Study the Electrochemical Behaviour of PdO, TiO2 and Perovskite-Type LaFeO3 Modified Carbon Paste Electrodes [PDF]
, 2019 Transition metals are highly sought after in electrode construction due to their eventual electrocatalytic effects. In this context, this work presents the study of several metal oxide modified electrodes focusing in the evaluation of their ...
Adelmo Menezes de Aguiar Filho +4 more
core +2 more sources