Results 41 to 50 of about 150,391 (120)

Preclinical pharmacology of alogabat: a novel GABAA-α5 positive allosteric modulator targeting neurodevelopmental disorders with impaired GABAA signaling

Frontiers in Pharmacology
BackgroundAlterations in the GABAergic system contribute to the pathophysiology of neurodevelopmental disorders, including autism spectrum disorder (ASD) and Angelman syndrome (AS), particularly in cases involving large deletions in the 15q11–13 region ...
Giuseppe Cecere, Theresa M. Ballard, Frederic Knoflach, Michael Honer, Joerg F. Hipp, Pilar Garces, Thomas Mueggler, Basil Künnecke, Andreas Bruns, Eric P. Prinssen, Philipp Schoenenberger, Philipp Janz, Roger Redondo, Barbara Biemans, Henner Knust, Andrés Olivares-Morales, Alessandro Brigo, Jan Michael Schulz, Daniel Bertrand, Michael Saxe, Eoin C. O’Connor, Maria-Clemencia Hernandez   +21 more
doaj   +1 more source

Product News

, 1980
Journal of Analytical Methods in Chemistry, Volume 2, Issue 4, Page 226-230, 1980.
wiley   +1 more source

Effect of degeneration stage on non-viral tissue transfection of rd10 retina ex vivo

Molecular Therapy: Nucleic Acids
Gene therapy has great potential for the treatment of inherited retinal diseases, as evidenced by the progress and ongoing research. Using the Sleeping Beauty (SB) transposon system, we developed a non-viral gene delivery system for electroporation-based
Jiao Zhang, Ziyu Bing, Corinne Marie, Zsuzsanna Izsvák, Frank Müller, Gabriele Thumann, Peter Walter, Sandra Johnen   +7 more
doaj   +1 more source

Retracted: The Effect of Mobile Social Media Sharing Behavior on the Subjective Well-Being and Mental Health Regulation of Internet Users

Occupational Therapy International, 2023
Occupational Therapy International
doaj   +1 more source

Nanoparticle delivery of VEGF-B mRNA promotes T cell infiltration within tumor and triggers robust antitumor immunity

Molecular Therapy: Nucleic Acids
The advancement of mRNA-based cancer immunotherapies has gained significant momentum, particularly after the success of mRNA vaccines during the COVID-19 pandemic and the recognition of mRNA vaccine development with the 2023 Nobel Prize.
Geqiang Zhang, Jun Tu, Yu Zhang, Jianli He, Guoyuan Peng, Qiuju Fan, Yirong Zhang, Mingming Zhang, Hongsheng Tan, Yingjie Xu, Jinke Cheng   +10 more
doaj   +1 more source

In vivo precision base editing to rescue mouse models of disease

Molecular Therapy: Nucleic Acids
CRISPR base editing enables precise, irreversible base conversions without inducing double-stranded breaks (DSBs) and has gained significant attention in recent years. By converting cytosine to thymine (C→T) or adenine to guanine (A→G), base editors (BEs)
Aaron Schindeler, Julian Chu, Christal Au-Yeung, Hsien-Yin Kao, Samantha L. Ginn, Alexandra K. O’Donohue   +5 more
doaj   +1 more source

Combined cancer immunotherapy with lipid nanoparticle delivery of oligo-based cGAS-agonistic adjuvant and peptide or mRNA vaccines

Molecular Therapy: Nucleic Acids
Therapeutic vaccines are promising for cancer immunotherapy in combination with immune checkpoint blockade (ICB). Though lipid nanoparticles (LNPs) hold great potential to deliver cancer therapeutic vaccines, LNPs delivering peptide or mRNA vaccines ...
Shurong Zhou, Yuqing Liang, Yu Hao, Qiyan Wang, You Xu, Ting Su, Furong Cheng, Guizhi Zhu   +7 more
doaj   +1 more source

The anticancer activity and mechanisms of She medicine herbs

Frontiers in Pharmacology
She Medicine, a traditional therapeutic system from China’s She ethnic group, shows promise in cancer treatment. This paper provides a comprehensive review of She medicinal herbs, focusing on their anticancer activities and underlying mechanisms ...
Yunxuan Miao, Yisheng Chen, Yisheng Chen, Yisheng Chen, Qiaofen Lan, Ruogu Chen, Jiajia Zhuang, Haojun Shi, Miao Wang, Jianhui Miao, Chengshou Lin   +10 more
doaj   +1 more source

Investigation of the mechanism underlying the Vasoprotective effects of red yeast rice extract in spontaneously hypertensive rats [PDF]

Hypertension is linked to endothelial dysfunction, characterized by an imbalance between relaxing and constricting factors in the vasculature. Increased activity in the renin-angiotensin-aldosterone system (RAAS) is implicated in hypertension as it ...
Tan, Jiunn Jye
core  

Biological potential of Lophosoria quadripinnata fern extract: integration of UHPLC/ESI/QToF/MS analysis, antioxidant activity, molecular docking and molecular dynamics simulation

Frontiers in Pharmacology
Lophosoria quadripinnata (J.F.Gmel.) C.Chr., a fern species from the Dicksoniaceae family, is widely distributed in Central and South America. This study aimed to identify the bioactive compounds in the aqueous extract of L.
Alfredo Torres-Benítez, José Erick Ortega-Valencia, Juan Rodrigo Salazar, Jaqueline Ley-Martínez, Javian Gallardo-Valdivia, Marta Sánchez, María Pilar Gómez-Serranillos, Gabriel Vargas-Arana, Gabriel Vargas-Arana, Mario J. Simirgiotis   +9 more
doaj   +1 more source