Results 1 to 10 of about 50 (50)
Triggering of RNA Interference with RNA–RNA, RNA–DNA, and DNA–RNA Nanoparticles [PDF]
ACS Nano, 2014 Control over cellular delivery of different functionalities and their synchronized activation is a challenging task. We report several RNA and RNA/DNA-based nanoparticles designed to conditionally activate the RNA interference in various human cells.
Vineet N. KewalRamani +11 more
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Combinatorics of RNA–RNA interaction [PDF]
Journal of Mathematical Biology, 2011 RNA-RNA binding is an important phenomenon observed for many classes of non-coding RNAs and plays a crucial role in a number of regulatory processes. Recently several MFE folding algorithms for predicting the joint structure of two interacting RNA molecules have been proposed.
Li, Thomas J X, Reidys, Christian
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RNA Chaperones, RNA Annealers and RNA Helicases [PDF]
RNA Biology, 2007 RNA molecules face difficulties when folding into their native structures. In the cell, proteins can assist RNAs in reaching their functionally active states by binding and stabilizing a specific structure or, in a quite opposite way, by interacting in a non-specific manner. These proteins can either facilitate RNA-RNA interactions in a reaction termed
Michael F. Jantsch +9 more
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RNA helicases in RNA decay [PDF]
Biochemical Society Transactions, 2018 RNA molecules have the tendency to fold into complex structures or to associate with complementary RNAs that exoribonucleases have difficulties processing or degrading. Therefore, degradosomes in bacteria and organelles as well as exosomes in eukaryotes have teamed-up with RNA helicases.
Khemici, Vanessa, Linder, Patrick
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Thermodynamics of RNA–RNA binding [PDF]
Bioinformatics, 2006 Abstract Background: Reliable prediction of RNA–RNA binding energies is crucial, e.g. for the understanding on RNAi, microRNA–mRNA binding and antisense interactions. The thermodynamics of such RNA–RNA interactions can be understood as the sum of two energy contributions: (1) the energy necessary to ‘open’ the binding site and (2) the ...
Stephan H. Bernhart +5 more
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RNA-Catalyzed RNA Ligation on an External RNA Template [PDF]
Chemistry & Biology, 2002 Variants of the hc ligase ribozyme, which catalyzes ligation of the 3' end of an RNA substrate to the 5' end of the ribozyme, were utilized to evolve a ribozyme that catalyzes ligation reactions on an external RNA template. The evolved ribozyme catalyzes the joining of an oligonucleotide 3'-hydroxyl to the 5'-triphosphate of an RNA hairpin molecule ...
Gerald F. Joyce, Kathleen E. McGinness
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Nanocircular RNAs for RNA interference [PDF]
Nucleic Acids Symposium Series, 2008 We designed and synthesized dumbbell-shaped nanocircular RNAs for RNA interference applications, which consist of a stem and two loops(1). RNA dumbbells are specifically recognized and cleaved by the human Dicer enzyme, and are thus transformed into double-stranded RNA in cells, although this RNA is resistant to degradation in serum.
Naoko Abe +4 more
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Frequency of RNA–RNA interaction in a model of the RNA World [PDF]
RNA, 2006 The RNA World model for prebiotic evolution posits the selection of catalytic/template RNAs from random populations. The mechanisms by which these random populations could be generated de novo are unclear. Non-enzymatic and RNA-catalyzed nucleic acid polymerizations are poorly processive, which means that the resulting short-chain RNA population could ...
Matthew B. Martin +2 more
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CHIMIA, 2019 Advances in the chemical synthesis of RNA have opened new possibilities to address current questions in RNA biology. Access to site-specifically modified oligoribonucleotides is often a pre-requisite for RNA chemical-biology projects. Driven by the enormous research efforts for development of oligonucleotide therapeutics, a wide range of ...
Rothlisberger, Pascal +2 more
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RNA as Multitude/RNA as One [PDF]
Chemistry & Biology, 2003 In the configurations formed by RNA and its ions there are structural possibilities not yet realized; some are hinted at in new work on the binding of an amino acid analog.
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