Results 41 to 50 of about 2,860,779 (318)

Automated immunohistochemical assessment ability to evaluate estrogen and progesterone receptor status compared with quantitative reverse transcription-polymerase chain reaction in breast carcinoma patients [PDF]

Journal of Pathology and Translational Medicine, 2021
Background This study aimed to investigate the capability of an automated immunohistochemical (IHC) evaluation of hormonal receptor status in breast cancer patients compared to a well-validated quantitative reverse transcription–polymerase chain reaction
Taesung Jeon, Aeree Kim, Chungyeul Kim
doaj   +1 more source

Detection of genome-scale ordered RNA structure (GORS) in genomes of positive-stranded RNA viruses:Implications for virus evolution and host persistence [PDF]

, 2004
Discrete RNA secondary and higher-order structures, typically local in extent, play a fundamental role in RNA virus replication. Using new bioinformatics analysis methods, we have identified genome-scale ordered RNA structure (GORS) in many genera and ...
Evans, David J, Simmonds, Peter, Tuplin, Andrew, Tuplin, A, Evans, DJ, Simmonds, P   +5 more
core   +1 more source

Determination of ribonuclease sequence-specificity using Pentaprobes and mass spectrometry [PDF]

, 2012
The VapBC toxin-antitoxin (TA) family is the largest of nine identified TA families. The toxin, VapC, is a metal-dependent ribonuclease that is inhibited by its cognate antitoxin, VapB. Although the VapBCs are the largest TA family, little is known about
Cook, Gregory M., Mackay, Joel, Cursons, Raymond T., Duyvestyn, Johanna Maria, Mckenzie, Joanna L., Smith, Tony C., Bendak, Katerina, Smith, Tony, Cursons, R. A.Y., Mackay, Joel P., Arcus, Vickery L., Duyvestyn, Johanna M., McKenzie, Joanna Leigh, https://orcid.org/   +13 more
core   +1 more source

Clinical study of real-time polymerase chain reaction test kit for SARS-CoV-2 ribonucleic acids detection

Фармакоэкономика, 2022
Objective: development and validation of a reverse transcription polymerase chain reaction (RT-PCR) test kit for SARS-CoV-2 ribonucleic acids (RNA) qualitative detection adapted for using with automated station for RNA extraction.Material and methods ...
M. Yu. Dmitryukova, A. A. Golod, M. E. Senina, A. E. Gushchin   +3 more
doaj   +1 more source

RNA-Catalyzed RNA Ligation on an External RNA Template [PDF]

Chemistry & Biology, 2002
Variants of the hc ligase ribozyme, which catalyzes ligation of the 3' end of an RNA substrate to the 5' end of the ribozyme, were utilized to evolve a ribozyme that catalyzes ligation reactions on an external RNA template. The evolved ribozyme catalyzes the joining of an oligonucleotide 3'-hydroxyl to the 5'-triphosphate of an RNA hairpin molecule ...
McGinness, Kathleen E, Joyce, Gerald F
openaire   +2 more sources

RNA Chemistry for RNA Biology

CHIMIA, 2019
Advances in the chemical synthesis of RNA have opened new possibilities to address current questions in RNA biology. Access to site-specifically modified oligoribonucleotides is often a pre-requisite for RNA chemical-biology projects. Driven by the enormous research efforts for development of oligonucleotide therapeutics, a wide range of ...
Rothlisberger, Pascal, Berk, Christian, Hall, Jonathan   +2 more
openaire   +5 more sources

Topology of RNA-RNA Interaction Structures [PDF]

Journal of Computational Biology, 2012
40 pages 15 ...
Jørgen E. Andersen, Fenix W. D. Huang, Robert C. Penner, Christian M. Reidys   +3 more
openaire   +6 more sources

Cooperativity and Interdependency between RNA Structure and RNA–RNA Interactions [PDF]

Non-Coding RNA, 2021
Complex RNA–RNA interactions are increasingly known to play key roles in numerous biological processes from gene expression control to ribonucleoprotein granule formation. By contrast, the nature of these interactions and characteristics of their interfaces, especially those that involve partially or wholly structured RNAs, remain elusive.
Ilias Skeparnias, Jinwei Zhang
openaire   +3 more sources

RT-PCR detection of SARS-CoV-2 in nasopharyngeal and salivary specimens: contribution of alternative collection systems and extraction processes to cope with mass screening. Interpretation of low viral loads

Journal of Laboratory Medicine, 2022
Due to massive screening of the persistent coronavirus SARS-CoV-2, supply difficulties emerged for swabs and extraction reagents leading to test alternative choices.
Robinet Sylvain, Parisot François, Cochonot Laurie, Schiltz Benjamin, Paboeuf Camille, Nedelec Clement, Espinet Laurent, Heddebaut Alexis   +7 more
doaj   +1 more source

Fast prediction of RNA-RNA interaction [PDF]

Algorithms for Molecular Biology, 2009
Abstract Background Regulatory antisense RNAs are a class of ncRNAs that regulate gene expression by prohibiting the translation of an mRNA by establishing stable interactions with a target sequence. There is great demand for efficient computational methods to predict the specific interaction between an ncRNA and its ...
Salari, Raheleh, Backofen, Rolf, Sahinalp, Cenk S.   +2 more
openaire   +6 more sources