Results 41 to 50 of about 510,206 (266)

Localization of the Bacterial RNA Infrastructure [PDF]

, 2011
The bacterial RNA network includes most of the same components found in eukaryotes, and many of the interactions that under lie transcription, RNA processing and stability, translation, and protein secretion are conserved. The major difference is that all of these functions take place in a single cellular compartment.
openaire   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Host A-to-I RNA editing signatures in intracellular bacterial and single-strand RNA viral infections

Frontiers in Immunology, 2023
BackgroundMicrobial infection is accompanied by remodeling of the host transcriptome. Involvement of A-to-I RNA editing has been reported during viral infection but remains to be elucidated during intracellular bacterial infections.ResultsHerein we ...
Zhi-Yuan Wei, Zhi-Yuan Wei, Zhi-Yuan Wei, Zhi-Xin Wang, Zhi-Xin Wang, Zhi-Xin Wang, Jia-Huan Li, Jia-Huan Li, Jia-Huan Li, Yan-Shuo Wen, Yan-Shuo Wen, Yan-Shuo Wen, Di Gao, Di Gao, Di Gao, Shou-Yue Xia, Shou-Yue Xia, Shou-Yue Xia, Yu-Ning Li, Yu-Ning Li, Yu-Ning Li, Xu-Bin Pan, Xu-Bin Pan, Xu-Bin Pan, Yan-Shan Liu, Yun-Yun Jin, Yun-Yun Jin, Yun-Yun Jin, Jian-Huan Chen, Jian-Huan Chen, Jian-Huan Chen   +30 more
doaj   +1 more source

Bacterial small RNAs in the Genus Rickettsia [PDF]

BMC Genomics, 2015
Rickettsia species are obligate intracellular Gram-negative pathogenic bacteria and the etiologic agents of diseases such as Rocky Mountain spotted fever (RMSF), Mediterranean spotted fever, epidemic typhus, and murine typhus. Genome sequencing revealed that R. prowazekii has ~25 % non-coding DNA, the majority of which is thought to be either "junk DNA"
Casey L. C. Schroeder, Hema P. Narra, Mark Rojas, Abha Sahni, Jignesh Patel, Kamil Khanipov, Thomas G. Wood, Yuriy Fofanov, Sanjeev K. Sahni   +8 more
openaire   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Novel Peptide Conjugates of Modified Oligonucleotides for Inhibition of Bacterial RNase P

Frontiers in Pharmacology, 2019
Novel alternatives to traditional antibiotics are now of great demand for the successful treatment of microbial infections. Here, we present the engineering and properties of new oligonucleotide inhibitors of RNase P, an essential bacterial enzyme.
Darya Novopashina, Darya Novopashina, Mariya Vorobyeva, Anton Nazarov, Anna Davydova, Nikolay Danilin, Lyudmila Koroleva, Lyudmila Koroleva, Andrey Matveev, Alevtina Bardasheva, Nina Tikunova, Nina Tikunova, Maxim Kupryushkin, Dmitrii Pyshnyi, Dmitrii Pyshnyi, Sidney Altman, Sidney Altman, Alya Venyaminova   +17 more
doaj   +1 more source

The Phage-Encoded N-Acetyltransferase Rac Mediates Inactivation of Pseudomonas aeruginosa Transcription by Cleavage of the RNA Polymerase Alpha Subunit

Viruses, 2020
In this study, we describe the biological function of the phage-encoded protein RNA polymerase alpha subunit cleavage protein (Rac), a predicted Gcn5-related acetyltransferase encoded by phiKMV-like viruses.
Pieter-Jan Ceyssens, Jeroen De Smet, Jeroen Wagemans, Natalia Akulenko, Evgeny Klimuk, Subray Hedge, Marleen Voet, Hanne Hendrix, Jan Paeshuyse, Bart Landuyt, Hua Xu, John Blanchard, Konstantin Severinov, Rob Lavigne   +13 more
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

Conformational flexibility of bacterial RNA polymerase [PDF]

Proceedings of the National Academy of Sciences, 2002
The structure of Escherichia coli core RNA polymerase (RNAP) was determined by cryo-electron microscopy and image processing of helical crystals to a nominal resolution of 15 Å. Because of the high sequence conservation between the core RNAP subunits, we were able to interpret the
Seth A, Darst, Natacha, Opalka, Pablo, Chacon, Andrey, Polyakov, Catherine, Richter, Gongyi, Zhang, Willy, Wriggers   +6 more
openaire   +2 more sources