Results 51 to 60 of about 2,524,971 (285)

Association of RNA Biosignatures With Bacterial Infections in Febrile Infants Aged 60 Days or Younger.

Journal of the American Medical Association (JAMA), 2016
IMPORTANCE Young febrile infants are at substantial risk of serious bacterial infections; however, the current culture-based diagnosis has limitations.
P. Mahajan, N. Kuppermann, A. Mejías, N. Suárez, D. Chaussabel, T. Casper, Bennett Smith, E. Alpern, E. Alpern, J. Anders, S. Atabaki, J. Bennett, Stephen J. Blumberg, B. Bonsu, D. Borgialli, A. Brayer, L. Browne, D. Cohen, E. Crain, A. Cruz, P. Dayan, Rajender K. Gattu, R. Greenberg, J. Hoyle, J. Hoyle, D. Jaffe, D. Jaffe, D. Levine, K. Lillis, J. Linakis, J. Muenzer, J. Muenzer, L. Nigrovic, E. Powell, A. Rogers, G. Roosevelt, R. Ruddy, M. Saunders, M. Saunders, M. Tunik, L. Tzimenatos, M. Vitale, J. Dean, O. Ramilo   +43 more
semanticscholar   +1 more source

Small RNAs in Bacterial Virulence and Communication [PDF]

Microbiology Spectrum, 2016
ABSTRACT Bacterial pathogens must endure or adapt to different environments and stresses during transmission and infection. Posttranscriptional gene expression control by regulatory RNAs, such as small RNAs and riboswitches, is now considered central to adaptation in many bacteria, including pathogens.
Sarah L. Svensson, Cynthia M. Sharma
openaire   +2 more sources

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Alternative transcription cycle for bacterial RNA polymerase

Nature Communications, 2020
In the canonical bacterial transcription, both nascent transcript and polymerase dissociate from template DNA. By employing multi-color single-molecule fluorescence imaging, here the authors show that RNA polymerases remain bound to DNA after the ...
Timothy T. Harden, Karina S. Herlambang, Mathew Chamberlain, Jean-Benoît Lalanne, Christopher D. Wells, Gene-Wei Li, Robert Landick, Ann Hochschild, Jane Kondev, Jeff Gelles   +9 more
doaj   +1 more source

Bacterial RNA polymerase caps RNA with various cofactors and cell wall precursors

Nucleic Acids Research, 2017
Bacterial RNA polymerase is able to initiate transcription with adenosine-containing cofactor NAD+, which was proposed to result in a portion of cellular RNAs being ‘capped’ at the 5′ end with NAD+, reminiscent of eukaryotic cap. Here we show that, apart
C. Julius, Yulia Yuzenkova
semanticscholar   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

An optimised method for the extraction of bacterial mRNA from plant roots infected with Escherichia coli O157:H7

Frontiers in Microbiology, 2014
Analysis of microbial gene expression during host colonisation provides valuable information on the nature of interaction, beneficial or pathogenic, and the adaptive processes involved.
Ashleigh eHolmes, Louise eBirse, Robert Wilson Jackson, Nicola eHolden   +3 more
doaj   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

Assessment of bacterial and viral gut communities in healthy and tumoral colorectal tissue using RNA and DNA deep sequencing

Cancer Medicine, 2023
Background Colorectal cancer (CRC) is known to present a distinct microbiome profile compared to healthy mucosa. Non‐targeted deep‐sequencing strategies enable nowadays full microbiome characterization up to species level.
Ainhoa Garcia‐Serrano, Dhananjay Mukhedkar, Emilie Hultin, Ulla Rudsander, Yvonne Wettergren, Agustín Enrique Ure, Joakim Dillner, Laila Sara Arroyo‐Mühr   +7 more
doaj   +1 more source

Localization of the Bacterial RNA Infrastructure [PDF]

, 2011
The bacterial RNA network includes most of the same components found in eukaryotes, and many of the interactions that under lie transcription, RNA processing and stability, translation, and protein secretion are conserved. The major difference is that all of these functions take place in a single cellular compartment.
openaire   +3 more sources