Results 51 to 60 of about 477,009 (248)

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Purification of Bacterial RNA from Infected Macrophages

Bio-Protocol, 2015
Studying the transcriptome of bacterial pathogens during infection is a very informative and effective tool for discovering genes that contribute to successful infection.
Lior Lobel, Nadejda Sigal, Anna Pasechnek, Anat Herskovits   +3 more
doaj   +1 more source

Assessment of bacterial and viral gut communities in healthy and tumoral colorectal tissue using RNA and DNA deep sequencing

Cancer Medicine, 2023
Background Colorectal cancer (CRC) is known to present a distinct microbiome profile compared to healthy mucosa. Non‐targeted deep‐sequencing strategies enable nowadays full microbiome characterization up to species level.
Ainhoa Garcia‐Serrano, Dhananjay Mukhedkar, Emilie Hultin, Ulla Rudsander, Yvonne Wettergren, Agustín Enrique Ure, Joakim Dillner, Laila Sara Arroyo‐Mühr   +7 more
doaj   +1 more source

The Acinetobacter baumannii model can explain the role of small non-coding RNAs as potential mediators of host-pathogen interactions

Frontiers in Molecular Biosciences, 2022
Bacterial small RNAs (sRNAs) research has accelerated over the past decade, boosted by advances in RNA-seq technologies and methodologies for capturing both protein–RNA and RNA–RNA interactions.
Meysam Sarshar, Daniela Scribano, Anna Teresa Palamara, Anna Teresa Palamara, Cecilia Ambrosi, Cecilia Ambrosi, Andrea Masotti   +6 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

RNA-Binding Proteins Driving the Regulatory Activity of Small Non-coding RNAs in Bacteria

Frontiers in Molecular Biosciences, 2020
Small non-coding RNAs (sRNAs) are critical post-transcriptional regulators of gene expression. Distinct RNA-binding proteins (RBPs) influence the processing, stability and activity of bacterial small RNAs.
Ana P. Quendera, André F. Seixas, Ricardo F. dos Santos, Inês Santos, João P. N. Silva, Cecília M. Arraiano, José M. Andrade   +6 more
doaj   +1 more source

Search for microRNAs expressed by intracellular bacterial pathogens in infected mammalian cells. [PDF]

PLoS ONE, 2014
MicroRNAs are expressed by all multicellular organisms and play a critical role as post-transcriptional regulators of gene expression. Moreover, different microRNA species are known to influence the progression of a range of different diseases, including
Yuki Furuse, Ryan Finethy, Hector A Saka, Ana M Xet-Mull, Dana M Sisk, Kristen L Jurcic Smith, Sunhee Lee, Jörn Coers, Raphael H Valdivia, David M Tobin, Bryan R Cullen   +10 more
doaj   +1 more source

Subcellular localization of a bacterial regulatory RNA [PDF]

Proceedings of the National Academy of Sciences, 2009
Eukaryotes and bacteria regulate the activity of some proteins by localizing them to discrete subcellular structures, and eukaryotes localize some RNAs for the same purpose. To explore whether bacteria also spatially regulate RNAs, the localization of tmRNA was determined using fluorescence in situ hybridization ...
Jay H. Russell, Kenneth C. Keiler
openaire   +3 more sources