Results 111 to 120 of about 249,749 (166)

RNA cleavage by small catalytic RNAs

Current Opinion in Structural Biology, 1995
Recent studies of the hammerhead ribozyme have provided an insight into its three-dimensional structure. In addition, studies using chemical probes, functional-group modification and mutational analysis, in combination with computer modelling, have led to proposals for the structure of both the hairpin and hepatitis delta virus ribozymes.
T, Tuschl, J B, Thomson, F, Eckstein
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SMALL CATALYTIC RNAs

Annual Review of Biochemistry, 1992
PERSPECTIVES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 641 ROLLING CIRCLE REPLICATION REQUIRES SPECIFIC RNA CLEAVAGE . . . . . . . 643 SELF-CLEAVAGE OF RNA VIA THE HAMMERHEAD STRUCTURE.. . . . . . . . . . . . . . .
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In vitro selection of catalytic RNAs

Current Opinion in Structural Biology, 1994
In vitro selection techniques are poised to allow a rapid expansion of the study of catalysis by RNA enzymes (ribozymes). This truly molecular version of genetics has already been applied to the study of the structures of known ribozymes and to the tailoring of their catalytic activity to meet specific requirements of substrate specificity or reaction
K B, Chapman, J W, Szostak
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The structure and function of catalytic RNAs

Science in China Series C: Life Sciences, 2009
Before the discovery of ribozymes, RNA had been proposed to function as a catalyst, based on the discovery that RNA folded into high-ordered structures as protein did. This hypothesis was confirmed in the 1980s, after the discovery of Tetrahymena group I intron and RNase P ribozyme.
QiJia, Wu, Lin, Huang, Yi, Zhang
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Catalytic RNAs

2015
This chapter looks at how RNA molecules catalyse chemical reactions, a domain which was previously thought to be reserved only for proteins. It clarifies that RNA has a more limited set of functional groups for building catalysts, which are confined to just four different nucleotides: A, C, G, and U.
David Elliott, Michael Ladomery
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Mitochondrial Targeting of Catalytic RNAs

2015
Genetic transformation of mitochondria in multicellular eukaryotes has remained inaccessible, hindering fundamental investigations and applications to gene therapy or biotechnology. In this context, we have developed a strategy to target nuclear transgene-encoded RNAs into mitochondria in plants.
Daria, Mileshina, Adnan Khan, Niazi, Eliza, Wyszko, Maciej, Szymanski, Romain, Val, Clarisse, Valentin, Jan, Barciszewski, André, Dietrich   +7 more
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The relationship between RNA catalytic processes

Origins of life and evolution of the biosphere, 1988
Proposals that an RNA-based genetic system preceded DNA, stem from the ability of RNA to store genetic information and to promote simple catalysis. However, to be a valid basis for the RNA world, RNA catalysis must demonstrate or be related to intrinsic chemical properties which could have existed in primordial times.
R, Cedergren, B F, Lang, D, Gravel
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Catalytic RNA and the origin of genetic systems

Trends in Genetics, 1990
The recent discovery of catalytic RNA molecules has provoked enormous interest in the origin of life and has given rise to new speculations about how living systems developed on the primitive earth. Here we outline why the discovery of catalytic RNA molecules has profound evolutionary implications, and then go on to discuss models for the emergence of ...
Lamond, Angus I., Gibson, Toby J.
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Catalytic RNA: Structure and Mechanism

Biochemical Society Transactions, 1993
The Hopkins Lecturer is given the charge of explaining how advances in other fields of science have had an impact on his or her own field of biochemistry. A moment’s thought revealed that it was not at all difficult to think of examples where other scientific fields have provided necessary groundwork for the study of RNA catalysis or RNA biochemistry ...
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The Catalytic Mechanism of RNA Polymerase II

Journal of Chemical Theory and Computation, 2011
Eukaryotic RNA polymerase II (RNAP II) transcribes the DNA into mRNA. The presence of two metal ions (usually Mg(2+)) and conserved aspartate residues in the active sites of all nucleic acid polymerases led to the adoption of a universal catalytic mechanism, known as the "two metal ion catalysis".
Alexandra T P, Carvalho, Pedro A, Fernandes, Maria J, Ramos   +2 more
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