Twenty years of "Lipid World": a fertile partnership with David Deamer [PDF]
, 2019 "The Lipid World" was published in 2001, stemming from a highly effective collaboration with David Deamer during a sabbatical year 20 years ago at the Weizmann Institute of Science in Israel.
Kahana, Amit +2 more
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Frontiers in Microbiology, 2019 The RNA-dependent RNA polymerases (RdRPs) encoded by the RNA viruses are a unique class of nucleic acid polymerases. Each viral RdRP contains a 500–600 residue catalytic module with palm, fingers, and thumb domains forming an encircled human right hand ...
Hengxia Jia, Hengxia Jia, Peng Gong
doaj +1 more source
The origins and physical roots of life’s dual – metabolic and genetic – nature [PDF]
, 2017 This review paper aims at a better understanding of the origin and physical foundation of life’s dual – metabolic and genetic – nature. First, I give a concise ‘top-down’ survey of the origin of life, i.e., backwards in time from extant DNA/RNA/protein ...
De Tiège, Alexis
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The structure of an RNAi polymerase links RNA silencing and transcription.
PLoS Biology, 2006 RNA silencing refers to a group of RNA-induced gene-silencing mechanisms that developed early in the eukaryotic lineage, probably for defence against pathogens and regulation of gene expression.
Paula S Salgado +5 more
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ARGONAUTE PIWI domain and microRNA duplex structure regulate small RNA sorting in Arabidopsis. [PDF]
, 2014 Small RNAs (sRNAs) are loaded into ARGONAUTE (AGO) proteins to induce gene silencing. In plants, the 5'-terminal nucleotide is important for sRNA sorting into different AGOs.
Carbonell, Alberto +9 more
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Kinetic analysis of an efficient DNA-dependent TNA polymerase. [PDF]
, 2005 alpha-l-Threofuranosyl nucleoside triphosphates (tNTPs) are tetrafuranose nucleoside derivatives and potential progenitors of present-day beta-d-2'-deoxyribofuranosyl nucleoside triphosphates (dNTPs).
Chaput, John C +6 more
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Inhibition of Bacterial RNase P RNA by Phenothiazine Derivatives
Biomolecules, 2016 There is a need to identify novel scaffolds and targets to develop new antibiotics. Methylene blue is a phenothiazine derivative, and it has been shown to possess anti-malarial and anti-trypanosomal activities.
Shiying Wu +2 more
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RRP6 from Trypanosoma brucei: crystal structure of the catalytic domain, association with EAP3 and activity towards structured and non-structured RNA substrates. [PDF]
PLoS ONE, 2014 RRP6 is a 3'-5' exoribonuclease associated to the eukaryotic exosome, a multiprotein complex essential for various RNA processing and degradation pathways.
Rosicler L Barbosa +5 more
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Machines on Genes: Enzymes that Make, Break and Move DNA and RNA [PDF]
, 2010 As the vital information repositories of the cell, the nucleic acids DNA and RNA pose many challenges as enzyme substrates. To produce, maintain and repair DNA and RNA, and to extract the genetic information that they encode, a battery of remarkable ...
Bates +13 more
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Transient tether between the SRP RNA and SRP receptor ensures efficient cargo delivery during cotranslational protein targeting [PDF]
, 2010 Kinetic control of macromolecular interactions plays key roles in biological regulation. An example of such control occurs in cotranslational protein targeting by the signal recognition particle (SRP), during which the SRP RNA and the cargo both ...
Shan, Shu-ou, Shen, Kuang
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