Results 71 to 80 of about 160,007 (267)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The Biomarker and Therapeutic Potential of Circular Rnas in Schizophrenia

Cells, 2020
Circular RNAs (circRNAs) are endogenous, single-stranded, most frequently non-coding RNA (ncRNA) molecules that play a significant role in gene expression regulation.
Artem Nedoluzhko, Natalia Gruzdeva, Fedor Sharko, Sergey Rastorguev, Natalia Zakharova, Georgy Kostyuk, Vadim Ushakov   +6 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM1

Nature Communications, 2019
Circular RNAs are known to regulate cancer. Here, the authors show that the circular RNA circTP63 promotes lung squamous cell carcinoma by competing with endogenous RNA to upregulate FOXM1.
Zhuoan Cheng, Chengtao Yu, Shaohua Cui, Hui Wang, Haojie Jin, Cun Wang, Botai Li, Meilin Qin, Chen Yang, Jia He, Qiaozhu Zuo, Siying Wang, Jun Liu, Weidong Ye, Yuanyuan Lv, Fangyu Zhao, Ming Yao, Liyan Jiang, Wenxin Qin   +18 more
doaj   +1 more source

Circular RNA hsa_circ_0000376 Participates in Tumorigenesis of Breast Cancer by Targeting miR-1285-3p

Technology in Cancer Research & Treatment, 2020
This study was designed to identify novel circular RNAs and the related regulatory axis to provide research targets for the diagnosis and treatment of breast cancer.
Ziqi Peng BM, Boyang Xu BM, Feng Jin MD
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Circular RNAs as Urinary Biomarkers [PDF]

Clinical Chemistry, 2019
Circular RNAs (circRNAs)3 bear a unique topological feature of circularity among the RNA species. CircRNAs, together with other RNA species without protein-coding potential, are grouped as noncoding RNAs (1). They are single-stranded, covalently closed circular RNA molecules and are hypothesized to be mainly generated through back-splicing of exons ...
W K, Jacky Lam, Y M, Dennis Lo
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The Landscape of Circular RNA in Cancer [PDF]

Cell, 2019
Circular RNAs (circRNAs) are an intriguing class of RNA due to their covalently closed structure, high stability, and implicated roles in gene regulation. Here, we used an exome capture RNA sequencing protocol to detect and characterize circRNAs across >2,000 cancer samples.
Josh N, Vo, Marcin, Cieslik, Yajia, Zhang, Sudhanshu, Shukla, Lanbo, Xiao, Yuping, Zhang, Yi-Mi, Wu, Saravana M, Dhanasekaran, Carl G, Engelke, Xuhong, Cao, Dan R, Robinson, Alexey I, Nesvizhskii, Arul M, Chinnaiyan   +12 more
openaire   +2 more sources

Cancer-related circular RNA: diverse biological functions

Cancer Cell International, 2021
Noncoding RNAs, including long noncoding RNAs (lncRNAs), microRNAs (miRNAs) and circular RNAs (circRNAs), are involved in regulating biological functions.
Dan Cheng, Jing Wang, Zigang Dong, Xiang Li   +3 more
doaj   +1 more source