Results 101 to 110 of about 502,163 (208)
Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA [PDF]
, 2007 Mammalian Dicer interacts with double-stranded RNA-binding protein TRBP or PACT to mediate RNA interference and micro-RNA processing. TRBP and PACT are structurally related but exert opposite regulatory activities on PKR.
Ching, YP, Jin, DY, Kok, KH, Ng, MHJ
core +1 more source
An observation of circular RNAs in bacterial RNA-seq data [PDF]
arXiv, 2016 Circular RNAs (circRNAs) are a class of RNA with an important role in micro RNA (miRNA) regulation recently discovered in Human and various other eukaryotes as well as in archaea. Here, we have analyzed RNA-seq data obtained from {\it Enterococcus faecalis} and {\it Escherichia coli} in a way similar to previous studies performed on eukaryotes.
arxiv
Effects of Nanoparticles on Double-Stranded RNA Stability in Moth Hemolymph [PDF]
, 2018 RNA interference (RNAi) is an immune response in which double-stranded RNA (dsRNA) suppresses a target gene. By designing dsRNA to target genes that are necessary for life, dsRNA can potentially be used as an insecticide.
Cooper, Anastasia +7 more
core
Frontiers in Microbiology, 2019 NrnC from Agrobacterium tumefaciens (At_NrnC, UniProt accession number A9CG28) is a nuclease containing a single DEDDy domain. Here, we determined the structures of both the apo and metal-ion-bound forms of At_NrnC.
Zenglin Yuan +3 more
doaj +1 more source
Unwinding and Rewinding: Double Faces of Helicase?
Journal of Nucleic Acids, 2012 Helicases are enzymes that use ATP-driven motor force to unwind double-stranded DNA or RNA. Recently, increasing evidence demonstrates that some helicases also possess rewinding activity—in other words, they can anneal two complementary single-stranded ...
Yuliang Wu
doaj +1 more source
RNA-GPT: Multimodal Generative System for RNA Sequence Understanding [PDF]
arXivRNAs are essential molecules that carry genetic information vital for life, with profound implications for drug development and biotechnology. Despite this importance, RNA research is often hindered by the vast literature available on the topic. To streamline this process, we introduce RNA-GPT, a multi-modal RNA chat model designed to simplify RNA ...
arxiv
Predicting sites of ADAR editing in double-stranded RNA
Nature Communications, 2011 ADAR (adenosine deaminase that acts on RNA) editing enzymes target coding and noncoding double-stranded RNA (dsRNA) and are essential for neuronal function.
J. Eggington, Tom Greene, B. Bass
semanticscholar +1 more source
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. [PDF]
, 2011 RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'.
Driver, SE +5 more
core
RNA-dependent RNA targeting by CRISPR-Cas9
eLife, 2018 Double-stranded DNA (dsDNA) binding and cleavage by Cas9 is a hallmark of type II CRISPR-Cas bacterial adaptive immunity. All known Cas9 enzymes are thought to recognize DNA exclusively as a natural substrate, providing protection against DNA phage and ...
Steven C Strutt +4 more
doaj +1 more source
On an RNA-membrane protogenome [PDF]
arXivSelected ribonucleotide sequences bind well to zwitterionic phospholipid bilayer membranes, though randomized RNAs do not. There are no evident repeated sequences in selected membrane binding RNAs. This implies small and varied motifs responsible for membrane affinity. Such subsequences have been partially defined. Bound RNAs require divalents like Mg2+
arxiv