Results 191 to 200 of about 384,029 (308)

A universal and orthogonal safety valve for CRISPR/Cas12a without chemical modification or external stimulation. [PDF]

Nucleic Acids Res
Luo W, Wu Y, Ni D, Zhang L, Zhang Y, Han X, Zhang Y, Pu J, He Y, Yin N, Wang W, Huang R, Guo Y, Sun Y, Xie G.   +14 more
europepmc   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

Mitochondrial double-stranded RNA fuels pancreatic cancer growth via RIG-I/TLR3 inflammation. [PDF]

Proc Natl Acad Sci U S A
Milcarek AT, Yeon M, Esposito C, Kulkarni P, Kossenkov AV, Madzo J, Faustino AM, Tang HY, Storaci AM, Palleschi A, Locatelli M, Vaira V, Iacocca MV, Ward A, Sabesan A, Petrelli NJ, Perego M, Altieri DC.   +17 more
europepmc   +1 more source

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source

Development and Optimization of CRISPR/Cas9-Assisted Recombineering in <i>Escherichia albertii</i>. [PDF]

MicroPubl Biol
Khan SA, Miller TM, Bhatt S, Li E.
europepmc   +1 more source

Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

Science, 2008
Lin Liu, I. Botos, Yan Wang, J. Leonard, J. Shiloach, D. Segal, D. Davies   +6 more
semanticscholar   +1 more source

Tailored Porous Bimetallic Nanozyme Platform for Full‐Cycle Therapeutics of Intestinal Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative‐inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA‐Cu‐Ma nanocomposite functions as a dual‐phase therapeutic platform with significant efficacy. It rapidly
Chenghao Qiu, Wenjing Xian, Mengxue Wang, Guozhi Zhao, Yanhuo Zhang, Zhiyu Zhou, Bo Sheng, Zhuo Zhen, Xie Liu, Shouwen Diao, Mengwei Tu, Chen Qiu, Huixian Wang, Jianbo Zhang, Peng Zhu, Tong Li   +15 more
wiley   +1 more source

DNA Nanostructures for siRNA Delivery. [PDF]

Bioconjug Chem
Madhanagopal BR, Youssef S, Chandrasekaran AR.   +2 more
europepmc   +1 more source

Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system.

Cell, 2015
Bernd Zetsche, J. Gootenberg, O. Abudayyeh, I. Slaymaker, K. Makarova, Patrick Essletzbichler, Sara Volz, J. Joung, J. van der Oost, A. Regev, E. Koonin, Feng Zhang   +11 more
semanticscholar   +1 more source

CD28‐Targeted Enzyme‐Responsive Conformation‐Switching Peptide Self‐Assembly for Selective T‐Cell Acute Lymphoblastic Leukemia (T‐ALL) Therapy

Advanced Science, EarlyView.
We developed the enzyme‐responsive peptide SAp‐CD28 to selectively target CD28‐overexpressing T‐ALL cells. Following phosphatase‐mediated activation, SAp‐CD28 undergoes conformational switching and nanooligomerization, resulting in the disruption of CD28 downstream signaling.
Jun Li, Ziyu Jia, Dekun Li, Zhi‐Wen Hu, Yinghao Ding, Shengyi Zhang, Shengkun Tuo, Zhimou Yang, Huisheng Fu, Ling Wang, Man‐Di Wang   +10 more
wiley   +1 more source