Results 131 to 140 of about 246,146 (311)

A new cancer/testis long noncoding RNA, the OTP-AS1 RNA

Scientific Reports
The orthopedia homeobox (OTP) gene encodes a homeodomain-containing transcription factor involved in brain development. OTP is mapped to human chromosome 5q14.1.
Iuliia K. Karnaukhova, Dmitrii E. Polev, Larisa L. Krukovskaya, Andrei A. Makashov, Alexey E. Masharsky, Olga V. Nazarenko, Irina V. Poverennaya, Vsevolod J. Makeev, Ekaterina B. Akulova, Andrei P. Kozlov   +9 more
doaj   +1 more source

Long Non-Coding RNA H19 Participates in Periodontal Inflammation via Activation of Autophagy

Journal of Inflammation Research, 2020
Runzhi Guo,1 Yiping Huang,1 Hao Liu,1 Yunfei Zheng,1 Lingfei Jia,2 Weiran Li1,3 1Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing 100081, People’s Republic of China; 2Central Laboratory, Peking University ...
Guo R, Huang Y, Liu H, Zheng Y, Jia L, Li W   +5 more
doaj  

Long noncoding RNAs in infection biology

Frontiers in Genetics, 2013
Long non-coding RNA have emerged as an increasingly well studied subset of non-coding RNAs (ncRNAs) following their recent discovery in a number of organisms including humans and characterization of their functional and regulatory roles in variety of ...
Vinod eScaria, Ayesha ePasha
doaj   +1 more source

Long noncoding RNA LINC00511 contributes to breast cancer tumourigenesis and stemness by inducing the miR-185-3p/E2F1/Nanog axis

Journal of experimental & clinical cancer research : CR, 2018
Emerging evidence have illustrated the vital role of long noncoding RNAs (lncRNAs) long intergenic non-protein coding RNA 00511 (LINC00511) on the human cancer progression and tumorigenesis.
Guanming Lu, Yueyong Li, Yanfei Ma, Jinlan Lu, Yongcheng Chen, Q. Jiang, Qiang Qin, Lifeng Zhao, Qianfang Huang, Zhizhai Luo, Shiqing Huang, Zhongheng Wei   +11 more
semanticscholar   +1 more source

Long noncoding RNAs in cervical cancer

Journal of Cancer Research and Therapeutics, 2018
This is a review about long noncoding RNAs (lncRNAs) and cervical cancer, especially the crucial regulating role played by lncRNAs on cervical cancer. LncRNAs are a big family with popular investigation in the last years. LncRNAs, as its noncoding proteins, once were considered to be useless RNAs without much more concern.
Dan, Shi, Cheng, Zhang, Xiaodong, Liu
openaire   +2 more sources

Preoperative Detection of Dual TERT Promoter Mutations in Thyroid Cancer: A Case Series

Diagnostic Cytopathology, EarlyView.
ABSTRACT Telomerase reverse transcriptase promoter (TERTp) mutations are associated with aggressive thyroid cancer and are most frequently found in anaplastic and poorly differentiated thyroid cancer. Pre‐operative thyroid nodule molecular testing can detect TERTp, denoting a high risk of malignancy and possible aggressive clinical features such as ...
Amir Harari, Jennifer Huiras, Yang Chen, Mohammed Alshalalfa, Yangyang Hao, Joshua P. Klopper, Richard T. Kloos, Bianca J. Vazquez   +7 more
wiley   +1 more source

Exosomal long noncoding RNA HOTTIP as potential novel diagnostic and prognostic biomarker test for gastric cancer

Molecular Cancer, 2018
Long noncoding RNA HOTTIP plays important roles in the generation and progression of human cancers. Exosomes participate in cellular communication by transmitting moleculars between cells and are regarded as suitable candidates for non-invasive diagnosis.
Rui Zhao, Yan-li Zhang, Xin Zhang, Yong-mei Yang, Xin Zheng, Xiao-hong Li, Yingjie Liu, Y. Zhang   +7 more
semanticscholar   +1 more source

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

The Super Enhancer‐Driven Long Noncoding RNA PRKCQ‐AS1 Promotes Neuroblastoma Tumorigenesis by Interacting With MSI2 Protein and Is Targetable by Small Molecule Compounds

Advanced Science
Tumorigenic drivers of MYCN gene nonamplified neuroblastoma remain largely uncharacterized. Long noncoding RNAs (lncRNAs) regulate tumorigenesis, however, there is little literature on therapeutic targeting of lncRNAs with small molecule compounds.
Sujanna Mondal, Pei Y. Liu, Janith Seneviratne, Antoine De Weck, Pooja Venkat, Chelsea Mayoh, Jing Wu, Jesper Maag, Jingwei Chen, Matthew Wong, Nenad Bartonicek, Poh Khoo, Lei Jin, Louise E. Ludlow, David S. Ziegler, Toby Trahair, Pieter Mestdagh, Belamy B. Cheung, Jinyan Li, Marcel E. Dinger, Ian Street, Xu D. Zhang, Glenn M. Marshall, Tao Liu   +23 more
doaj   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source