Results 81 to 90 of about 111,170 (313)

The Smooth Long Noncoding RNA SENCR [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2014
Long noncoding RNAs (lncRNAs) have emerged as novel regulators of gene expression, but their mode of action is diverse and ill understood. There are few examples that lncRNAs are also involved in cardiovascular development as well as in cardiovascular (patho)physiology (Figure).
Thomas, Thum, Regalla, Kumarswamy
openaire   +2 more sources

Race and Household Income Are Associated With Disease Outcomes in Pediatric Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Hospitalized in the United States

Arthritis Care &Research, EarlyView.
Objective Race and household income impact outcomes in patients with rheumatic conditions; however, their role in pediatric antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) remains poorly understood. We aimed to evaluate whether race and ethnicity and household income are associated with severe AAV disease and renal outcomes among
Roberto Alejandro Valdovinos, William Daniel Soulsby III, Emily von Scheven   +2 more
wiley   +1 more source

A noncoding RNA containing a SINE-B1 motif associates with meiotic metaphase chromatin and has an indispensable function during spermatogenesis. [PDF]

PLoS ONE, 2017
A search for early response genes that are activated following germ cell induction from mouse embryonic stem cells in vitro led us to the isolation of a long noncoding RNA that contains a SINE (short interspersed element)-B1F motif that was named R53. In
Ryusuke Nakajima, Takuya Sato, Takehiko Ogawa, Hideyuki Okano, Toshiaki Noce   +4 more
doaj   +1 more source

애기 장대에서 잎의 노화 관련 long noncoding RNA (lncRNA)의 조절 역할의 글로벌 분석

, 2021
식물,노화,애기장대,전사체,Long noncoding RNA,lncRNA,leaf senescence,Arabidopsis, senescence-associated long noncoding RNA ...
Jungyeon Kim
core   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

The role of miRNA and lncRNA in heterotopic ossification pathogenesis

Stem Cell Research & Therapy, 2022
Heterotopic ossification (HO) is the formation of bone in non-osseous tissues, such as skeletal muscles. The HO could have a genetic or a non-genetic (acquired) background, that is, it could be caused by musculoskeletal trauma, such as burns, fractures ...
Łukasz Pulik, Bartosz Mierzejewski, Aleksandra Sibilska, Iwona Grabowska, Maria Anna Ciemerych, Paweł Łęgosz, Edyta Brzóska   +6 more
doaj   +1 more source

Splicing regulation by long noncoding RNAs [PDF]

Nucleic Acids Research, 2018
Massive high-throughput sequencing techniques allowed the identification of thousands of noncoding RNAs (ncRNAs) and a plethora of different mRNA processing events occurring in higher organisms. Long ncRNAs can act directly as long transcripts or can be processed into active small si/miRNAs.
Romero Barrios, Natali, Legascue, Maria Florencia, Benhamed, Moussa, Ariel, Federico, Crespi, Martin   +4 more
openaire   +4 more sources

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Downregulation of a novel long noncoding RNA TRPM2-AS promotes apoptosis in non–small cell lung cancer

Tumor Biology, 2017
Non–small cell lung cancer is one of the most common types of cancer, and the prognosis of non–small cell lung cancer is still poor. Recent evidence has proved that long noncoding RNA is involved in tumorigenesis.
Cheng Huang, Yingzhi Qin, Hongsheng Liu, Naixin Liang, Yeye Chen, Dongjie Ma, Zhijun Han, Xiaohui Xu, Xiaoyun Zhou, Jia He, Shanqing Li   +10 more
doaj   +1 more source