Results 61 to 70 of about 8,401,372 (300)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Cytotopic localization by long noncoding RNAs [PDF]

Current Opinion in Cell Biology, 2013
Cells are highly organized structures. In addition to membrane delimited organelles, proteins and RNAs can organize themselves into specific domains. Some examples include stress granules and subnuclear bodies. This level of organization is essential for the correct execution of multiple processes in the cell, ranging from cell signaling to assembly of
Pedro J, Batista, Howard Y, Chang
openaire   +2 more sources

The molecular dynamics of long noncoding RNA control of transcription in PTEN and its pseudogene

, 2017
Significance In recent years, noncoding RNA transcripts have been found to interact with genes and modulate their ability to be transcribed and made into protein.
Lister, Nicholas, Grander, Dan, Nicholas Lister, Ataide, Sandro F, Galina Shevchenko, Dan Grander, Per Johnsson, Groen, Jessica, Jessica Groen, Walshe, James L, Linda Vidarsdóttir, Shevchenko, Galina, Johnsson, Per, Morris, Kevin V, Kevin V. Morris, James L. Walshe, Sandro F. Ataide, Vidarsdottir, Linda, Lister, N, Walshe, JL, Johnsson, P,, Grander, D, Groen, J, Vidarsdottir, L, Morris, KV, Ataide, SF, Shevchenko, G   +26 more
core   +1 more source

Probing the phenomics of noncoding RNA

eLife, 2013
Genetic knockout experiments on mice confirm that some long noncoding RNA molecules have developmental functions.
John S Mattick
doaj   +1 more source

Is Evolutionary Conservation a Useful Predictor for Cancer Long Noncoding RNAs? Insights from the Cancer LncRNA Census 3

Non-Coding RNA, 2022
Evolutionary conservation is a measure of gene functionality that is widely used to prioritise long noncoding RNAs (lncRNA) in cancer research. Intriguingly, while updating our Cancer LncRNA Census (CLC), we observed an inverse relationship between year ...
Adrienne Vancura, Alejandro H. Gutierrez, Thorben Hennig, Carlos Pulido-Quetglas, Frank J. Slack, Rory Johnson, Simon Haefliger   +6 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

The Smooth Long Noncoding RNA SENCR [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2014
Long noncoding RNAs (lncRNAs) have emerged as novel regulators of gene expression, but their mode of action is diverse and ill understood. There are few examples that lncRNAs are also involved in cardiovascular development as well as in cardiovascular (patho)physiology (Figure).
Thomas, Thum, Regalla, Kumarswamy
openaire   +2 more sources

A noncoding RNA containing a SINE-B1 motif associates with meiotic metaphase chromatin and has an indispensable function during spermatogenesis. [PDF]

PLoS ONE, 2017
A search for early response genes that are activated following germ cell induction from mouse embryonic stem cells in vitro led us to the isolation of a long noncoding RNA that contains a SINE (short interspersed element)-B1F motif that was named R53. In
Ryusuke Nakajima, Takuya Sato, Takehiko Ogawa, Hideyuki Okano, Toshiaki Noce   +4 more
doaj   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source