Results 41 to 50 of about 111,170 (313)
Non-Coding RNA, 2022 Evolutionary conservation is a measure of gene functionality that is widely used to prioritise long noncoding RNAs (lncRNA) in cancer research. Intriguingly, while updating our Cancer LncRNA Census (CLC), we observed an inverse relationship between year ...
Adrienne Vancura +6 more
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, 2022 Long noncoding RNAs (lncRNAs) play critical regulatory roles in human development and disease. Although there are over 100,000 samples with available RNA sequencing (RNA-seq) data, many lncRNAs have yet to be annotated.
Kwon, Euijin +5 more
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NONCODE v3.0: integrative annotation of long noncoding RNAs [PDF]
Nucleic Acids Research, 2011 Facilitated by the rapid progress of high-throughput sequencing technology, a large number of long noncoding RNAs (lncRNAs) have been identified in mammalian transcriptomes over the past few years. LncRNAs have been shown to play key roles in various biological processes such as imprinting control, circuitry controlling pluripotency and differentiation,
Dechao Bu +14 more
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Non-Syndromic Intellectual Disability and Its Pathways: A Long Noncoding RNA Perspective
, 2021 Non-syndromic intellectual disability (NS-ID or idiopathic) is a complex neurodevelopmental disorder that represents a global health issue. Although many efforts have been made to characterize it and distinguish it from syndromic intellectual disability (
Jessica O. Santis +8 more
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Long Noncoding RNA in Hematopoiesis and Immunity [PDF]
Immunity, 2015 Dynamic gene expression during cellular differentiation is tightly coordinated by transcriptional and post-transcriptional mechanisms. An emerging theme is the central role of long noncoding RNAs (lncRNAs) in the regulation of this specificity.
Satpathy, Ansuman T., Chang, Howard Y.
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Patterns of selective constraints in noncoding DNA of rice [PDF]
, 2007 Background Several studies have investigated the relationships between selective constraints in introns and their length, GC content and location within genes. To date, however, no such investigation has been done in plants.
Peter D Keightley +11 more
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Circular Intronic Long Noncoding RNAs [PDF]
Molecular Cell, 2013 We describe the identification and characterization of circular intronic long noncoding RNAs in human cells, which accumulate owing to a failure in debranching. The formation of such circular intronic RNAs (ciRNAs) can be recapitulated using expression vectors, and their processing depends on a consensus motif containing a 7 nt GU-rich element near the
Zhang, Yang +8 more
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Long Noncoding RNA: Genome Organization and Mechanism of Action
, 2017 For the last four decades, we have known that noncoding RNAs maintain critical housekeeping functions such as transcription, RNA processing, and translation.
Debosree Pal +5 more
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Long Noncoding RNAs as Players in Breast Tumorigenesis
, 2020 Comprehensive analysis of the mammalian genome uncovered the discovery of pervasive transcription of large RNA transcripts that do not code for proteins, namely, long noncoding RNAs (lncRNAs).
Achour, Cyrinne,, Aguilo, Francesca,
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LncATLAS database for subcellular localization of long noncoding RNAs [PDF]
, 2017 The subcellular localization of long noncoding RNAs (lncRNAs) holds valuable clues to their molecular function. However, measuring localization of newly discovered lncRNAs involves time-consuming and costly experimental methods.
Carlevaro Fita, Joana +15 more
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