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Long Noncoding RNAs in Cardiovascular Disease
Current Opinion in Cardiology, 2019 Purpose of review Here, we review recent findings on the role of long noncoding RNAs (lncRNAs) in cardiovascular disease (CVD). In addition, we highlight some of the latest findings in lncRNA biology, providing an outlook for future avenues of lncRNA research in CVD. Recent findings
Kohlmaier, Alexander +2 more
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Long Noncoding RNAs in Cancer Pathways [PDF]
Cancer Cell, 2016 Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now understand that lncRNAs drive many ...
Adam M, Schmitt, Howard Y, Chang
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Long noncoding RNA Cfast regulates cardiac fibrosis
Molecular Therapy: Nucleic Acids, 2021 Cardiac fibrosis occurs in most cardiac diseases, which reduces cardiac muscle compliance, impairs both systolic and diastolic heart function and, ultimately, leads to heart failure.
Feng Zhang +17 more
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Long noncoding RNAs in cardiometabolic disorders
FEBS Letters, 2022 The advancement of medical technology has led not only to an increase in life expectancy but also to a rise in aging‐related diseases. Aging promotes metabolic disorders, in turn affecting cardiovascular health. Derailment of biological processes in the pancreas, liver, adipose tissue, and skeletal muscle impairs glucose and lipid metabolism, and ...
Rio P. Juni +3 more
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Research Progress on Plant Long Non-Coding RNA
Plants, 2020 Non-coding RNAs (ncRNAs) that were once considered “dark matter” or “transcriptional noise” in genomes are research hotspots in the field of epigenetics.
Ling Wu +4 more
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Noncoding RNAs Associated with Therapeutic Resistance in Pancreatic Cancer
Biomedicines, 2021 Therapeutic resistance is an inevitable impediment towards effective cancer therapies. Evidence accumulated has shown that the signaling pathways and related factors are fundamentally responsible for therapeutic resistance via regulating diverse cellular
Seung Wan Son +3 more
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Dose-Response, 2020 We explored whether long noncoding RNA growth arrest-specific transcript 5 (LncRNA-GAS5) small interfering RNA (siRNA) reduced cartilage destruction in obese mice with adjuvant-induced arthritis.
Hongwei Chen +6 more
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Long Non-Coding RNA MEG3 in Metal Carcinogenesis
Toxics, 2023 Most transcripts from human genomes are non-coding RNAs (ncRNAs) that are not translated into proteins. ncRNAs are divided into long (lncRNAs) and small non-coding RNAs (sncRNAs).
Zhuo Zhang +3 more
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Evolution and Functions of Long Noncoding RNAs [PDF]
Cell, 2009 RNA is not only a messenger operating between DNA and protein. Transcription of essentially the entire eukaryotic genome generates a myriad of non-protein-coding RNA species that show complex overlapping patterns of expression and regulation. Although long noncoding RNAs (lncRNAs) are among the least well-understood of these transcript species, they ...
Ponting, C, Oliver, P, Reik, W
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ALDB: a domestic-animal long noncoding RNA database. [PDF]
PLoS ONE, 2015 Long noncoding RNAs (lncRNAs) have attracted significant attention in recent years due to their important roles in many biological processes. Domestic animals constitute a unique resource for understanding the genetic basis of phenotypic variation and ...
Aimin Li +5 more
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