Results 31 to 40 of about 8,401,372 (300)

Myeloid leukemia vulnerabilities embedded in long noncoding RNA locus MYNRL15 [PDF]

, 2023
Summary: The noncoding genome presents a largely untapped source of new biological insights, including thousands of long noncoding RNA (lncRNA) loci. While lncRNA dysregulation has been reported in myeloid malignancies, their functional relevance remains
Michelle Ng, Lonneke Verboon, Hasan Issa, Raj Bhayadia, Michael Heuser, Dorit Borchert, Dirk Heckl, Robert Winkler, Jan-Henning Klusmann, Marit Willemijn Vermunt, Leah Schüler, Marie-Laure Yaspo, Konstantin Schuschel, Eniko Regenyi, Dirk Reinhardt, Oriol Alejo   +15 more
core   +4 more sources

Role of Related Regulatory Long Noncoding RNAs on Mammalian Spermatogenesis

Reproductive and Developmental Medicine, 2017
Long noncoding RNAs (lncRNAs) are transcribed by RNA molecules, which are longer than 200 nucleotides that lack an open reading frame of significant length and possess no obvious protein-coding capacity.
Kang-Sheng Liu, Xiao-Dong Mao, Feng Pan, Ling-Juan Gao, Xiu-Feng Ling   +4 more
doaj   +1 more source

Integrated Profiling Revealed Potential Regulatory Networks Among Long Noncoding RNAs and mRNAs in Mucosal Gastric Cancer

Technology in Cancer Research & Treatment, 2020
Gastric cancer is one of the most commonly occurring cancers worldwide. Investigation of long noncoding RNAs is of increasing interest, particularly in relation to their contribution to progression and prognosis of gastric cancers; however, insufficient ...
Ke-kang Sun MD, Xiao-jun Shen MM, Dong Yang MM, Yang Jiao PhD, Xiao-yang Wu PhD   +4 more
doaj   +1 more source

Human cancer long non-coding RNA transcriptomes. [PDF]

PLoS ONE, 2011
Once thought to be a part of the 'dark matter' of the genome, long non-coding RNAs (lncRNAs) are emerging as an integral functional component of the mammalian transcriptome.
Ewan A Gibb, Emily A Vucic, Katey S S Enfield, Greg L Stewart, Kim M Lonergan, Jennifer Y Kennett, Daiana D Becker-Santos, Calum E MacAulay, Stephen Lam, Carolyn J Brown, Wan L Lam   +10 more
doaj   +1 more source

KCNQ1OT1: An Oncogenic Long Noncoding RNA

Biomolecules, 2021
Long noncoding RNAs (lncRNAs) are transcripts greater than 200 nucleotides that do not code for proteins but regulate gene expression. Recent studies indicate that lncRNAs are involved in the modulation of biological functions in human disease.
Patrice Cagle, Qi Qi, Suryakant Niture, Deepak Kumar   +3 more
doaj   +1 more source

A hepatitis C virus cis-acting replication element forms a long-range RNA-RNA interaction with upstream RNA sequences in NS5B [PDF]

, 2008
The genome of hepatitis C virus (HCV) contains cis-acting replication elements (CREs) comprised of RNA stem-loop structures located in both the 5' and 3' non-coding regions (NCR), and in the NS5B coding sequence.
Diviney, Sinéad, Elliot, R., Evans, David John, Evans, D., Armstrong, V, Tuplin, Andrew, Evans, D.J., Struthers, Madeleine, Struthers, M., Elliott, Richard M., Diviney, S., Tuplin, A., Armstrong, V., Struthers, M, Simmonds, Peter, Elliott, Richard Michael, Armstrong, Victoria, Tuplin, A, Evans, David J., Simmonds, P., Diviney, S, Elliott, R.M., Simmonds, P, Evans, David John; id_orcid   +23 more
core   +1 more source

Long noncoding RNAs regulate adipogenesis [PDF]

Proceedings of the National Academy of Sciences, 2013
The prevalence of obesity has led to a surge of interest in understanding the detailed mechanisms underlying adipocyte development. Many protein-coding genes, mRNAs, and microRNAs have been implicated in adipocyte development, but the global expression patterns and functional contributions of long noncoding RNA (lncRNA) during adipogenesis have not ...
Sun, Lei, Goff, Loyal, Trapnell, Cole, Alexander, Ryan, Lo, Kinyui Alice, Hacisuleyman, Ezgi, Sauvageau, Martin, Tazon-Vega, Barbara, Kelley, David Roy, Hendrickson, David Gillis, Yuan, Bingbing, Kellis, Manolis, Lodish, Harvey F., Rinn, John   +13 more
openaire   +5 more sources

Assessment of the Cardiac Noncoding Transcriptome by Single-Cell RNA Sequencing Identifies FIXER, a Conserved Profibrogenic Long Noncoding RNA. [PDF]

, 2023
BACKGROUND Cardiac fibroblasts have crucial roles in the heart. In particular, fibroblasts differentiate into myofibroblasts in the damaged myocardium, contributing to scar formation and interstitial fibrosis.
Bernasconi, R., Wigger, Leonore, Plaisance, Isabelle, Alexandre Sarre, Leonore Wigger, Pedrazzini, Thierry, Plaisance, I., Sarre, A., Wyss, Tania, Wyss, T., Panagiotis Chouvardas, Arantxa González, Pulido Quetglas, C., Aghagolzadeh, Parisa, Mohamed Nemir, Nemir, Mohamed, Bernasconi, Riccardo, Tania Wyss, Sarre, Alexandre, Wigger, L., Treibel, Thomas A, Riccardo Bernasconi, Pedrazzini, T., Thierry Pedrazzini, Nemir, M., González, Arantxa, Rory Johnson, Johnson, R., Pulido Quetglas, Carlos, Isabelle Plaisance, Chouvardas, P., Chouvardas, Panagiotis, Johnson, Rory, Thomas A. Treibel, Aghagolzadeh, P., Carlos Pulido Quetglas, Parisa Aghagolzadeh, González, A., Treibel, T.A.   +38 more
core   +1 more source

LINC00467: an oncogenic long noncoding RNA

Cancer Cell International, 2022
Long non-coding RNAs (lncRNAs) have been found to play essential roles in the cell proliferation, fission and differentiation, involving various processes in humans.
Xuyu Chen, Qian Luo, Yanan Xiao, Jing Zhu, Yirao Zhang, Jie Ding, Juan Li   +6 more
doaj   +1 more source

Hfq binding changes the structure of Escherichia coli small noncoding RNAs OxyS and RprA, which are involved in the riboregulation of rpoS [PDF]

, 2013
: OxyS and RprA are two small noncoding RNAs (sRNAs) that modulate the expression of rpoS, encoding an alternative sigma factor that activates transcription of multiple Escherichia coli stress-response genes.
Taylor, James E., Callaghan, Anastasia J., Helen A. Vincent, Phillips, Jack O., Cary, Peter, Vincent, H., Peter D. Cary, Sobott, F., Jack O. Phillips, Frank Sobott, Vincent, Helen A., Henderson, Charlotte A., Stone, Carlanne, Alessandra Casamento, Henderson, Charlotte, Carlanne M. Stone, Anastasia J. Callaghan, Darren M. Gowers, Cary, Peter D., Charlotte A. Henderson, James E.N. Taylor, Casamento, A., Callaghan, Anastasia, Phillips, Jack, Gowers, Darren, Casamento, Alessandra, Stone, Carlanne M., Sobott, Frank, Gowers, Darren M.   +28 more
core   +1 more source