Results 51 to 60 of about 111,170 (313)

Long Noncoding RNA Regulation of Pluripotency

Stem Cells International, 2016
Pluripotent stem cells (PSCs) represent a unique kind of stem cell, as they are able to indefinitely self-renew and hold the potential to differentiate into any derivative of the three germ layers.
Alessandro Rosa, Monica Ballarino
doaj   +1 more source

Long Noncoding RNAs in Cardiovascular Disease

Current Opinion in Cardiology, 2019
Purpose of review Here, we review recent findings on the role of long noncoding RNAs (lncRNAs) in cardiovascular disease (CVD). In addition, we highlight some of the latest findings in lncRNA biology, providing an outlook for future avenues of lncRNA research in CVD. Recent findings
Kohlmaier, Alexander, Holdt, Lesca M., Teupser, Daniel   +2 more
openaire   +2 more sources

Long Noncoding RNAs in Cancer Pathways [PDF]

Cancer Cell, 2016
Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now understand that lncRNAs drive many ...
Adam M, Schmitt, Howard Y, Chang
openaire   +2 more sources

Myeloid leukemia vulnerabilities embedded in long noncoding RNA locus MYNRL15 [PDF]

, 2023
The noncoding genome presents a largely untapped source of new biological insights, including thousands of long noncoding RNA (lncRNA) loci. While lncRNA dysregulation has been reported in myeloid malignancies, their functional relevance remains to be ...
Klusmann, J., Reinhardt, D., Winkler, R., Vermunt, M., Borchert, D., Heuser, M., Yaspo, M. ; https://orcid.org/, Bhayadia, R., Alejo, O., Regenyi, E., Ng, M., Schuschel, K., Issa, H., Schüler, L., Heckl, D., Verboon, L.   +15 more
core   +2 more sources

Long noncoding RNA Cfast regulates cardiac fibrosis

Molecular Therapy: Nucleic Acids, 2021
Cardiac fibrosis occurs in most cardiac diseases, which reduces cardiac muscle compliance, impairs both systolic and diastolic heart function and, ultimately, leads to heart failure.
Feng Zhang, Xuyang Fu, Masaharu Kataoka, Ning Liu, Yingchao Wang, Feng Gao, Tian Liang, Xiaoxuan Dong, Jianqiu Pei, Xiaoyun Hu, Wei Zhu, Hong Yu, Douglas B. Cowan, Xinyang Hu, Zhan-Peng Huang, Jian’an Wang, Da-Zhi Wang, Jinghai Chen   +17 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Long noncoding RNAs in cardiometabolic disorders

FEBS Letters, 2022
The advancement of medical technology has led not only to an increase in life expectancy but also to a rise in aging‐related diseases. Aging promotes metabolic disorders, in turn affecting cardiovascular health. Derailment of biological processes in the pancreas, liver, adipose tissue, and skeletal muscle impairs glucose and lipid metabolism, and ...
Rio P. Juni, Kelly C. 't Hart, Riekelt H. Houtkooper, Reinier A. Boon   +3 more
openaire   +3 more sources

Prognostic value and clinical significance of long noncoding RNA CASC2 in human malignancies: a meta-analysis

, 2018
Juan Cai,1,* Xueliang Zuo,2,* Zhiqiang Chen,3,4,* Wenying Zhao,1 Yiping Zhu,1 Zhengxiang Zhang,1 Xiaobing Ye1 1Department of Oncology, The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China; 2Department of ...
Zhu Y, Zuo X, Cai J, Zhao W, Wenying Zhao, Ye X, Zhiqiang Chen, Juan Cai, Zhengxiang Zhang, Chen Z, Zhang Z, Yiping Zhu, Xiaobing Ye, Xueliang Zuo   +13 more
core   +1 more source

Roles of long noncoding RNA in triple‐negative breast cancer

, 2023
Introduction Long noncoding RNAs (lncRNAs) play crucial roles in regulating various hallmarks in cancers. Triple‐negative (Estrogen receptor, ER; Human epidermal growth factor receptor 2, HER2; Progesterone receptor, PR) breast cancer (TNBC) is the most ...
Soha, Kazi, Pillai, Suja, Das, Plabon Kumar, Siddika, Ayesha, Farhadul Islam, Khan Mohammad Rashel, Rashel, Khan Mohammad, Suja Pillai, Plabon Kumar Das, Abdul Auwal, Rahman, Md Arifur, Ayesha Siddika, Auwal, Abdul, Islam, Farhadul, Kazi Soha, Md. Arifur Rahman   +15 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source