Results 51 to 60 of about 6,901,872 (255)
Long Noncoding RNA Regulation of Pluripotency
Stem Cells International, 2016 Pluripotent stem cells (PSCs) represent a unique kind of stem cell, as they are able to indefinitely self-renew and hold the potential to differentiate into any derivative of the three germ layers.
Alessandro Rosa, Monica Ballarino
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Long Noncoding RNAs in Cardiovascular Disease
Current Opinion in Cardiology, 2019 Purpose of review Here, we review recent findings on the role of long noncoding RNAs (lncRNAs) in cardiovascular disease (CVD). In addition, we highlight some of the latest findings in lncRNA biology, providing an outlook for future avenues of lncRNA research in CVD. Recent findings
Kohlmaier, Alexander +2 more
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Evolution and Functions of Long Noncoding RNAs [PDF]
Cell, 2009 RNA is not only a messenger operating between DNA and protein. Transcription of essentially the entire eukaryotic genome generates a myriad of non-protein-coding RNA species that show complex overlapping patterns of expression and regulation. Although long noncoding RNAs (lncRNAs) are among the least well-understood of these transcript species, they ...
Ponting, C, Oliver, P, Reik, W
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Long noncoding RNA Cfast regulates cardiac fibrosis
Molecular Therapy: Nucleic Acids, 2021 Cardiac fibrosis occurs in most cardiac diseases, which reduces cardiac muscle compliance, impairs both systolic and diastolic heart function and, ultimately, leads to heart failure.
Feng Zhang +17 more
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Long noncoding RNAs in cardiometabolic disorders
FEBS Letters, 2022 The advancement of medical technology has led not only to an increase in life expectancy but also to a rise in aging‐related diseases. Aging promotes metabolic disorders, in turn affecting cardiovascular health. Derailment of biological processes in the pancreas, liver, adipose tissue, and skeletal muscle impairs glucose and lipid metabolism, and ...
Rio P. Juni +3 more
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The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Long Noncoding RNA in Hematopoiesis and Immunity [PDF]
Immunity, 2015 Dynamic gene expression during cellular differentiation is tightly coordinated by transcriptional and post-transcriptional mechanisms. An emerging theme is the central role of long noncoding RNAs (lncRNAs) in the regulation of this specificity.
Satpathy, Ansuman T., Chang, Howard Y.
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Noncoding RNAs Associated with Therapeutic Resistance in Pancreatic Cancer
Biomedicines, 2021 Therapeutic resistance is an inevitable impediment towards effective cancer therapies. Evidence accumulated has shown that the signaling pathways and related factors are fundamentally responsible for therapeutic resistance via regulating diverse cellular
Seung Wan Son +3 more
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
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