Results 51 to 60 of about 8,401,372 (300)

Long Noncoding RNAs in Cancer Pathways [PDF]

Cancer Cell, 2016
Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now understand that lncRNAs drive many ...
Adam M, Schmitt, Howard Y, Chang
openaire   +2 more sources

The long non-coding RNA

Plant Communications
The chromosomes of allotetraploid cotton have accumulated numerous structural variations (SVs), which are critical features underlying the acquisition of polyploid vigor and the success of cotton domestication.
Jin Han, Yupeng Hao, Hongyu Wu, Ke Nie, Luyao Wang, Zeyi Cao, Xiaoyuan Tao, Ting Zhao, Chuanzao Mao, Tianzhen Zhang, Lei Fang, Xueying Guan   +11 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Prognostic value and clinical significance of long noncoding RNA CASC2 in human malignancies: a meta-analysis

, 2018
Juan Cai,1,* Xueliang Zuo,2,* Zhiqiang Chen,3,4,* Wenying Zhao,1 Yiping Zhu,1 Zhengxiang Zhang,1 Xiaobing Ye1 1Department of Oncology, The First Affiliated Hospital, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China; 2Department of ...
Zhu Y, Zuo X, Cai J, Zhao W, Wenying Zhao, Ye X, Zhiqiang Chen, Juan Cai, Zhengxiang Zhang, Chen Z, Zhang Z, Yiping Zhu, Xiaobing Ye, Xueliang Zuo   +13 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Long Noncoding RNA Regulation of Pluripotency

Stem Cells International, 2016
Pluripotent stem cells (PSCs) represent a unique kind of stem cell, as they are able to indefinitely self-renew and hold the potential to differentiate into any derivative of the three germ layers.
Alessandro Rosa, Monica Ballarino
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Expression and Functional Studies on the Noncoding RNA, PRINS. [PDF]

, 2012
PRINS, a noncoding RNA identified earlier by our research group, contributes to psoriasis susceptibility and cellular stress response. We have now studied the cellular and histological distribution of PRINS by using in situ hybridization and demonstrated
Széll Márta, Kemény Lajos, Dobozy Attila, Csörgő Sándorné Bata Zsuzsanna, Bacsa, Sarolta, Dobozy, Attila, Szegedi, Krisztina, Antal, Mária, István Németh, Krisztina Szegedi, Bacsa Sarolta, Lajos Kemény, Mária Antal, Göblös, Anikó, Széll, Márta, Sarolta Bacsa, Attila Dobozy, Németh István Balázs, Csörgő-Bata, Zsuzsanna, Anikó Göblös, Göblös Anikó, Németh, István Balázs, Márta Széll, Szegedi Krisztina, Kemény, Lajos, Antal Mária, Zsuzsanna Bata-Csörgő   +26 more
core   +1 more source

Methodological considerations for circulating long noncoding RNA quantification [PDF]

, 2022
In the past decade, significant resources have been invested in long noncoding RNA (lncRNA) research. Despite the knowledge available, we are far from incorporation of lncRNA into clinical practice.
Devaux, Yvan, Sopić, Miron, de Gonzalo-Calvo, David, Miron Sopić, Yvan Devaux, David de Gonzalo-Calvo   +5 more
core   +1 more source