Results 191 to 200 of about 1,540,463 (333)

Respiratory virus mRNA vaccines: mRNA Design, clinical studies, and future challenges

Animal Models and Experimental Medicine, EarlyView.
Abstract Respiratory infectious diseases frequently erupt on a global scale, with RNA viruses, such as SARS‐CoV‐2, RSV, and influenza viruses, posing challenges to vaccine development due to their high mutation rates. Traditional vaccine development cycles are lengthy and struggle to keep pace with rapidly evolving viruses, whereas messenger RNA (mRNA)
Linlin Zheng, Han Feng
wiley   +1 more source

Exploring ENPP5 as a diagnostic biomarker for sepsis: a comprehensive bioinformatics analysis. [PDF]

BMC Infect Dis
Gao J, Li Y, Huang J, Wei C, Chen J, Huang A, Liu N, Lu Y, Yang S.   +8 more
europepmc   +1 more source

Comparative pathogenicity of vaccinia virus and mpox virus infections in CAST/EiJ mice: Exploring splenomegaly and transcriptomic profiles

Animal Models and Experimental Medicine, EarlyView.
We successfully constructed CAST/EiJ mice models infected with low‐dose vaccinia virus (VACV‐L), high‐dose VACV (VACV‐H), and mpox virus (MPXV), demonstrating that VACV‐L and MPXV infections induced splenomegaly in mice, and VACV‐H infection caused mortality in mice.
Yongzhi Hou, Jianrong Ma, Baoying Huang, Na Li, Lin Zhu, Ziqing Jia, Jiasen Yang, Jingjing Zhang, Wenjie Tan, Jing Xue   +9 more
wiley   +1 more source

A Strand-Specific Quantitative RT-PCR Method for Detecting vRNA, cRNA, and mRNA of H7N9 Avian Influenza Virus in a Mouse Model. [PDF]

Viruses
Wang B, Wang G, Wang YH, Liu X, Li M, Kong H, Chen H, Jiang L, Li C.   +8 more
europepmc   +1 more source

Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia

Cell Reports, 2017
D. An, Jessica L. Schneller, A. Frassetto, Shi Liang, Xuling Zhu, Ji-Sun park, M. Theisen, Sue‐Jean Hong, Jenny Zhou, Rajini Rajendran, B. Levy, R. Howell, Gilles Besin, Vladimir Presnyak, S. Sabnis, Kerry E. Murphy-Benenato, E. Kumarasinghe, Timothy Salerno, C. Mihai, Christine M. Lukacs, R. Chandler, L. Guey, C. Venditti, P. Martini   +23 more
semanticscholar   +1 more source

Identification of ferroptosis‐related genes involved in chronic obstructive pulmonary disease based on bioinformatics analysis

Animal Models and Experimental Medicine, EarlyView.
The design of the entire paper. Green part represents the bioinformatics analysis approach. Yellow part represents the ideas of animal experiment. Abstract Background Chronic obstructive pulmonary disease (COPD) is a type of chronic respiratory disease.
Xuejing Luan, Jinghui Xie, Lu Zhang, Xiao Ma, Lichangtian Jiao, Jie Zhu   +5 more
wiley   +1 more source

A promising frontier of circulating messenger RNA in liquid biopsy: From mechanisms to clinical applications. [PDF]

Int J Cancer
Li M, Yu Y, Liu G, Zhang S, Luo C, Hu S, Wan S, Zhao L.   +7 more
europepmc   +1 more source

Long noncoding RNA GCH1 mediates mitophagy via the PTEN‐induced kinase 1/Parkin pathway to drive chondrocyte dysfunction and cartilage degeneration in osteoarthritis

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract illustrates the role of lncRNA‐GCH1 in regulating mitophagy and its downstream effects on chondrocyte dysfunction and cartilage degradation in osteoarthritis (OA). Elevated lncRNA‐GCH1 stabilizes PINK1 protein, enhancing mitophagy and mitochondrial turnover.
Gang Zeng, Yujun Sun, Taihe Liu, Wenzhou Liu, Yanbo Chen, Jionglin Wu, Jiayuan Zheng, Weidong Song, Yue Ding   +8 more
wiley   +1 more source

Optoregulated mRNA Delivery Controls Pleiotropic Immune Signaling for Tumor‐Targeted Therapy

Angewandte Chemie, EarlyView.
A light‐induced transfection system (LITS) was designed to precisely control the delivery of mRNA, achieving spatiotemporal de‐coupling of the pleotropic inflammatory and tolerogenic signals of interleukin‐2 to conduct safe eradication of tumors. Abstract Spatiotemporal control of protein expression remains a critical challenge in messenger RNA (mRNA ...
Pengwen Chen, Guanghao Hu, Yuki Nakashima, Zhining Xu, Takayoshi Watanabe, Soichiro Kondo, Ervin Kovács, Horacio Cabral   +7 more
wiley   +2 more sources

Age-related changes in lncRNA expression in sperm. [PDF]

Transl Androl Urol
Zhou Q, Li G, Ji H, Ji J, Ling Z, Sun J, Ding H, Zhang J, Ling X, Chen X, Xu L.   +10 more
europepmc   +1 more source