Results 21 to 30 of about 1,347,350 (288)
Cotranslational microRNA mediated messenger RNA destabilization
MicroRNAs are small (22 nucleotide) regulatory molecules that play important roles in a wide variety of biological processes. These RNAs, which bind to targeted mRNAs via limited base pairing interactions, act to reduce protein production from those ...
Trinh To Tat+4 more
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m6A-dependent regulation of messenger RNA stability
N6-methyladenosine (m6A) is the most prevalent internal (non-cap) modification present in the messenger RNA of all higher eukaryotes. Although essential to cell viability and development, the exact role of m6A modification remains to be determined.
Xiao Wang+12 more
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Lymph node CXCL17 messenger RNA: A new prognostic biomarker for colon cancer
Lymph node metastasis is the most important prognostic characteristic of colorectal cancer. Carcinoembryonic antigen messenger RNA was shown to detect tumor cells that have disseminated to lymph nodes of colorectal cancer patients and to be at least as ...
Yomna Rashad+7 more
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A convenient technique for the partial purification of large quantities of functional, poly(adenylic acid)-rich mRNA is described. The method depends upon annealing poly(adenylic acid)-rich mRNA to oligothymidylic acid-cellulose columns and its elution ...
H. Aviv, P. Leder
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Genetic and epigenetic reprogramming caused by disease states in other tissues is always systemically reflected in peripheral blood leukocytes (PBLs).
Yinli He+10 more
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Structural signatures of thermal adaptation of bacterial ribosomal RNA, transfer RNA, and messenger RNA. [PDF]
Temperature adaptation of bacterial RNAs is a subject of both fundamental and practical interest because it will allow a better understanding of molecular mechanism of RNA folding with potential industrial application of functional thermophilic or ...
Clara Jegousse+4 more
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Nanoscale platforms for messenger RNA delivery.
Messenger RNA (mRNA) has become a promising class of drugs for diverse therapeutic applications in the past few years. A series of clinical trials are ongoing or will be initiated in the near future for the treatment of a variety of diseases.
Bin Li, Xinfu Zhang, Yizhou Dong
semanticscholar +1 more source
Messenger RNA medicines are basically sets of instructions and these instructions direct cells in the body to make proteins. mRNA plays a key role in human biology and it is a molecule that carries genetic code from DNA in a cell nucleus to ribosomes the protein making machinery of cells. Messenger RNA carries the genetic information copied from DNA in
openaire +2 more sources
The emerging role of RNA modifications in the regulation of mRNA stability
Gene activity: the significance of RNA modification Messenger RNA molecules play their key role in directing the manufacture of proteins via translating the genetic information in DNA.
Sung Ho Boo, Yoon Ki Kim
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Modelling ribosome kinetics and translational control on dynamic mRNA.
The control of protein synthesis and the overall levels of various proteins in the cell is critical for achieving homoeostasis. Regulation of protein levels can occur at the transcriptional level, where the total number of messenger RNAs in the overall ...
Eric C Dykeman
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