FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Annotation and functional prediction of RNA helicases in Ustilago maydis [PDF]
IMA FungusRNA helicases are conserved enzymes found in both prokaryotes and eukaryotes. They function in all aspects of RNA metabolism and are known to influence various cellular and metabolic processes.
Amanda M. Seto, Barry J. Saville
doaj +3 more sources
Molecular studies on the sweet potato virus disease and its two causal agents [PDF]
, 2002 The studies presented in this thesis contribute to an increased understanding of the molecular aspects, variability and interaction of the two most important viral pathogens of sweet potato (Ipomoea batatas L): Sweet potato feathery mottle virus (SPFMV ...
Kreuze, Jan
core
Plastid redox state and sugars: Interactive regulators of nuclear-encoded photosynthetic gene expression [PDF]
, 2001 Feedback regulation of photosynthesis by carbon metabolites has long been recognized, but the underlying cellular mechanisms that control this process remain unclear.
Dominy, P J +3 more
core +2 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
RNA silencing response in chloroplast-replicating viroid siRNA biogenesis in plants
Phytopathology ResearchRNA silencing represents a cellular regulatory and defence mechanism in eukaryotes across kingdoms. In plants, a combined functionality of DCL2 and DCL3 is crucial for their synergistic defence against whilst DCL4 is required for nucleus-replicating ...
Pengcheng Zhang +7 more
doaj +1 more source
Top Three Strategies of ss(+)RNA Plant Viruses: Great Opportunists and Ecosystem Tuners with a Small Genome. [PDF]
Viruses, 2021 Oberemok VV +3 more
europepmc +1 more source
Molecular studies on a complex of potyviruses infecting solanaceous crops, and some specific virus-host interactions [PDF]
, 2003 This thesis constitutes a comprehensive analysis of the molecular and biological characteristics of three potyviruses (genus Potyvirus, family Potyviridae) naturally occurring in cultivated and wild species of family Solanaceae: Peru tomato virus (PTV ...
Spetz, Carl
core
Phytochrome activates the plastid-encoded RNA polymerase for chloroplast biogenesis via nucleus-to-plastid signaling. [PDF]
, 2019 Light initiates chloroplast biogenesis by activating photosynthesis-associated genes encoded by not only the nuclear but also the plastidial genome, but how photoreceptors control plastidial gene expression remains enigmatic.
Blaha, Gregor M +6 more
core +2 more sources
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source