Results 251 to 260 of about 5,212,902 (357)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Citrus phloem specific transcriptional profiling through the development of a citrus tristeza virus expressed translating ribosome affinity purification system. [PDF]

Plant Methods
Culver JN, Vallar M, Burchard E, Kamens S, Lair S, Qi Y, Collum TD, Dardick C, El-Mohtar CA, Rogers EE.   +9 more
europepmc   +1 more source

RNA interference in plants

Turkish Bulletin of Hygiene and Experimental Biology, 2015
Kursat Derici, Asli Fazlioglu, İlker Büyük, Demet Cansaran-Duman, Demet Cansaran Duman, Sümer Aras, Semra Soydam Aydin   +6 more
openaire   +1 more source

CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability

Molecular Oncology, EarlyView.
Micronuclei, formed during cell division in chromosomal instability settings, rupture and lead to the accumulation of immunogenic double‐stranded RNA in the cytoplasm, activating MAVS‐dependent interferon signaling and innate antitumor immunity.
Aglaia Skolariki, Rose L. Jady‐Clark, Eileen E. Parkes   +2 more
wiley   +1 more source

The LARP6 La module from <i>Tetrabaena socialis</i> reveals structural and functional differences from plant and animal LARP6 homologues. [PDF]

RNA Biol
Lewis EM, Becker O, Symons AN, LaCoss C, Baclig AJ, Guzman A, Sanders C, Gonzalez L, Warner LR, Lewis KA.   +9 more
europepmc   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Comparative transcriptome analysis and candidate gene mining for fire blight of Pear resistance in Korla fragrant Pear (Pyrus sinkiangensis Yü). [PDF]

Sci Rep
Li Y, Ye Y, Huan W, Ji J, Ma J, Sheng Q, Lei J.   +6 more
europepmc   +1 more source

Botrytis small RNA Bc-siR37 suppresses plant defense genes by cross-kingdom RNAi

RNA Biology, 2017
Ming Wang, Arne Weiberg, E. Dellota, D. Yamane, Hailing Jin   +4 more
semanticscholar   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Decoding the mitogenome of rosemary (Salvia rosmarinus): insights into genome evolution, structural dynamics and prospects for mitochondrial engineering. [PDF]

BMC Plant Biol
Feng Y, Liu Y, Han J, Huang Y, Lee J, Kokubugata G, Qi Z, Yan X.   +7 more
europepmc   +1 more source