Long non-coding RNAs as a source of new peptides [PDF]
Deep transcriptome sequencing has revealed the existence of many transcripts that lack long or conserved open reading frames and which have been termed long non-coding RNAs (lncRNAs). Despite the existence of several well-characterized lncRNAs that play roles in the regulation of gene expression, the vast majority of them do not yet have a known ...
arxiv +1 more source
Growth-laws and invariants from ribosome biogenesis in lower Eukarya [PDF]
Eukarya and Bacteria are the most evolutionarily distant domains of life, which is reflected by differences in their cellular structure and physiology. For example, Eukarya feature membrane-bound organelles such as nuclei and mitochondria, whereas Bacteria have none.
arxiv +1 more source
IL-4Rα Blockade by Dupilumab Decreases Staphylococcus aureus Colonization and Increases Microbial Diversity in Atopic Dermatitis. [PDF]
Dupilumab is a fully human antibody to interleukin-4 receptor α that improves the signs and symptoms of moderate to severe atopic dermatitis (AD). To determine the effects of dupilumab on Staphylococcus aureus colonization and microbial diversity on the ...
Ardeleanu, Marius+16 more
core +2 more sources
Molecular and Morphological identification of the genus Dineutus MacLeay, 1825 (Coleoptera, Gyrinidae) from Eastern Ghats, India [PDF]
The present study is on the morphology and molecular data of the genus Dineutus MacLeay, were collected from the Eastern Ghats mountains in Odisha, Andhra Pradesh, Telangana, Tamil Nadu states located in the eastern Ghats of India.
Jaiswal Deepa+5 more
doaj
Diagnostic Techniques for Early Detection of Phytoplasma Diseases
Phytoplasmas are a type of bacteria, specifically belonging to the group of Mollicutes, characterized by their lack of cell walls and inability to be cultured in lab settings.
Naofel Aljafer, Hail Rihan
doaj +1 more source
Improving RNA secondary structure prediction via state inference with deep recurrent neural networks [PDF]
The problem of determining which nucleotides of an RNA sequence are paired or unpaired in the secondary structure of an RNA, which we call RNA state inference, can be studied by different machine learning techniques. Successful state inference of RNA sequences can be used to generate auxiliary information for data-directed RNA secondary structure ...
arxiv +1 more source
Size, shape, and flexibility of RNA structures
Determination of sizes and flexibilities of RNA molecules is important in understanding the nature of packing in folded structures and in elucidating interactions between RNA and DNA or proteins.
Cantor C. R.+4 more
core +1 more source
Stochastic thermodynamics and modes of operation of a ribosome: a network theoretic perspective [PDF]
The ribosome is one of the largest and most complex macromolecular machines in living cells. It polymerizes a protein in a step-by-step manner as directed by the corresponding nucleotide sequence on the template messenger RNA (mRNA) and this process is referred to as `translation' of the genetic message encoded in the sequence of mRNA transcript.
arxiv +1 more source
Identification of novel small molecule inhibitors of ETS transcription factors
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla+9 more
wiley +1 more source
Background: Hunting activity in the Mayan communities has increased due to COVID-19 and domestic dogs have gained more importance. Due to its proximity to humans, domestic dogs are a bridge between tick-borne diseases and humans and their peri-domestic ...
Karla Rossanet Dzul-Rosado+8 more
doaj +1 more source