Results 81 to 90 of about 129,806 (287)

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Purification of 70S Ribosomes from Bacillus subtilis

Bio-Protocol, 2015
The eubacterial ribosome (70S) is a macromolecular complex that is composed of a small (30S) subunit and a large (50S) subunit. The small subunit comprises the 16S ribosomal RNA (rRNA) and more than 20 ribosomal proteins (r-proteins), whereas the large ...
Shota Suzuki, Genki Akanuma, Fujio Kawamura   +2 more
doaj   +1 more source

Structural basis for ribosomal 16S rRNA cleavage by the cytotoxic domain of colicin E3

Nature Structural &Molecular Biology, 2010
The toxin colicin E3 targets the 30S subunit of bacterial ribosomes and cleaves a phosphodiester bond in the decoding center. We present the crystal structure of the 70S ribosome in complex with the cytotoxic domain of colicin E3 (E3-rRNase).
C. Ng, Kathrin Lang, Nicola A. G. Meenan, Amit Sharma, A. Kelley, C. Kleanthous, V. Ramakrishnan   +6 more
semanticscholar   +1 more source

Knockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor's loss

FEBS Open Bio, EarlyView.
Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.
Nobukazu Nameki, Chika Tomisawa, Soichiro Hoshino, Hidehiko Shimizu, Masashi Abe, Sho Arai, Kanako Kuwasako, Naoki Asakawa, Yusuke Inoue, Takuro Horii, Izuho Hatada, Masakatsu Watanabe   +11 more
wiley   +1 more source

Multiple Exoribonucleases Catalyze Maturation of the 3′ Terminus of 16S Ribosomal RNA (rRNA)*

Journal of Biological Chemistry, 2013
Background: The RNases involved in 3′ maturation of E. coli 16S rRNA were not known. Results: E. coli mutants lacking RNase II, RNase R, PNPase, and RNase PH accumulate 17S rRNA precursor.
S. Sulthana, M. Deutscher
semanticscholar   +1 more source

Clostridium bacteraemia characterised by 16S ribosomal RNA gene sequencing [PDF]

Journal of Clinical Pathology, 2005
Background:Owing to problems in accurate species identification of the diverse genus clostridium, the epidemiology and pathogenicity of many species are not fully understood. Moreover, previous studies on clostridium bacteraemia have been limited and relied only on phenotypic species identification.Aims:To characterise the epidemiology, disease ...
Woo, PCY, Yuen, KY, Lau, SKP, Tang, BSF, Fung, AMY, Chan, KM   +5 more
openaire   +5 more sources

Compound Heterozygous MRPS14 Variants Associated With Leigh Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT MRPS14 (uS14m) is a nuclear‐encoded ribosomal protein important for mitochondria‐specific translation. To date, only a single individual with a recessive MRPS14‐related disorder (also known as COXPD38) has been reported. We report an additional subject possessing novel compound heterozygous MRPS14 variants (p.Asp37Asn, p.Asn60Asp). The subject
Maria Gabriela Otero, Christina Freeman, Ruchi Shah, Renkui Bai, Hong Cui, Marian Castro, Zachary Myers, Eric Choy, Derek Chan, Molly Easter, Sophia Y. Zhao, Madeline Babros, Ruchi Garg, Matthew Deardorff, Franklin Moser, Tyler Mark Pierson   +15 more
wiley   +1 more source

Actinomycetoma caused by Nocardia otitidiscaviarum: Report of a case in Taiwan with long-term follow-up

Dermatologica Sinica, 2013
Actinomycetoma is a chronic granulomatous infection, with Nocardia species being one of the infecting pathogens. Infections caused by N. otitidiscaviarum are relatively rare compared with those caused by other Nocardia species.
Min-Hui Chi, Rosaline Chung-Yee Hui, Chin-Fang Lu, Li-Cheng Yang, Shu-Ying Li   +4 more
doaj   +1 more source

RNA–DNA differences in human mitochondria restore ancestral form of 16S ribosomal RNA

Genome Research, 2013
RNA transcripts are generally identical to the underlying DNA sequences. Nevertheless, RNA–DNA differences (RDDs) were found in the nuclear human genome and in plants and animals but not in human mitochondria.
Dan Bar-Yaacov, Gal Avital, Liron Levin, Allison L. Richards, Naomi Hachen, Boris Rebolledo Jaramillo, A. Nekrutenko, R. Zarivach, D. Mishmar   +8 more
semanticscholar   +1 more source

Whole‐Blood RNA Sequencing Profiling of Patients With Rheumatoid Arthritis Treated With Tofacitinib

ACR Open Rheumatology, EarlyView.
Objective Patients with rheumatoid arthritis (RA) often fail to respond to therapies, including JAK inhibitors (JAKi), and treatment allocation is made via a trial‐and‐error strategy. A comprehensive analysis of responses to JAKi, including tofacitinib, by RNA sequencing (RNAseq) would allow the discovery of transcriptomic markers with a two‐fold ...
Chiara Bellocchi, Ennio Giulio Favalli, Gabriella Maioli, Elena Agape, Marzia Rossato, Matteo Paini, Adriana Severino, Barbara Vigone, Martina Biggioggero, Elena Trombetta, Roberto Caporali, Lorenzo Beretta   +11 more
wiley   +1 more source