Nop53p is required for late 60S ribosome subunit maturation and nuclear export in yeast [PDF]
, 2005 We report that Ypl146cp/Nop53p is associated with pre-60S ribosomal complexes and localized to the nucleolus and nucleoplasm. in cells depleted of Nop53p synthesis of the rRNA components of the 60S ribosomal subunit is severely inhibited, with strikingly
Tollervey, D, Thomson, E
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Recent Advances on the Structure and Function of RNA Acetyltransferase Kre33/NAT10
Cells, 2019 Ribosome biogenesis is one of the most energy demanding processes in the cell. In eukaryotes, the main steps of this process occur in the nucleolus and include pre-ribosomal RNA (pre-rRNA) processing, post-transcriptional modifications, and assembly of ...
Sophie Sleiman, Francois Dragon
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Ribosomal RNA regulates chromosome clustering during mitosis
Cell Discovery, 2022 Noncoding RNAs are known to associate with mitotic chromosomes, but the identities and functions of chromosome-associated RNAs in mitosis remain elusive. Here, we show that rRNA species associate with condensed chromosomes during mitosis.
Kai Ma +7 more
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Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors [PDF]
, 2014 Ribosome biogenesis is a key process for maintaining protein synthetic capacity in dividing or growing cells, and requires coordinated production of ribosomal proteins and ribosomal RNA (rRNA), including the processing of the latter.
Proud, C. +17 more
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RNA G-quadruplex structures control ribosomal protein production
Scientific Reports, 2021 Four-stranded G-quadruplex (G4) structures form from guanine-rich tracts, but the extent of their formation in cellular RNA and details of their role in RNA biology remain poorly defined.
Dhaval Varshney +5 more
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Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation [PDF]
, 2007 A family of HEAT-repeat containing ribosome synthesis factors was previously identified in Saccharomyces cerevisiae. We report the detailed characterization of two of these factors, Utp10 and Utp20, which were initially identified as components of the ...
Tollervey, David +2 more
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Loss of m1acp3Ψ Ribosomal RNA Modification Is a Major Feature of Cancer
Cell Reports, 2020 Summary: The ribosome is an RNA-protein complex that is essential for translation in all domains of life. The structural and catalytic core of the ribosome is its ribosomal RNA (rRNA).
Artem Babaian +10 more
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HMG-boxes, ribosomopathies and neurodegenerative disease
Frontiers in Genetics, 2023 The UBTF E210K neuroregression syndrome is a predominantly neurological disorder caused by recurrent de novo dominant variants in Upstream Binding Factor, that is, essential for transcription of the ribosomal RNA genes. This unusual form of ribosomopathy
Tom Moss +4 more
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RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components [PDF]
, 2004 Sequential events in macromolecular biosynthesis are often elegantly coordinated. The small ribosomal subunit (SSU) processome is a large ribonucleoprotein (RNP) required for processing of precursors to the small subunit RNA, the 18S, of the ribosome. We
Granneman, Sander; id_orcid +6 more
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Cross-site comparison of ribosomal depletion kits for Illumina RNAseq library construction
BMC Genomics, 2018 Background Ribosomal RNA (rRNA) comprises at least 90% of total RNA extracted from mammalian tissue or cell line samples. Informative transcriptional profiling using massively parallel sequencing technologies requires either enrichment of mature poly ...
Zachary T. Herbert +20 more
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