Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation. [PDF]
, 2013 The initiation of protein synthesis plays an essential regulatory role in human biology. At the center of the initiation pathway, the 13-subunit eukaryotic translation initiation factor 3 (eIF3) controls access of other initiation factors and mRNA to the
Arias-Palomo, Ernesto +6 more
core +1 more source
Loss of m1acp3Ψ Ribosomal RNA Modification Is a Major Feature of Cancer
Cell Reports, 2020 Summary: The ribosome is an RNA-protein complex that is essential for translation in all domains of life. The structural and catalytic core of the ribosome is its ribosomal RNA (rRNA).
Artem Babaian +10 more
doaj +1 more source
Protocol dependence of sequencing-based gene expression measurements. [PDF]
PLoS ONE, 2011 RNA Seq provides unparalleled levels of information about the transcriptome including precise expression levels over a wide dynamic range. It is essential to understand how technical variation impacts the quality and interpretability of results, how ...
Tal Raz +5 more
doaj +1 more source
Puromycin Sensitivity of Ribosomal Label after Incorporation of 14C-Labelled Amino Acids into Isolated Mitochondria from Neurospora crassa [PDF]
, 1969 Radioactive amino acids were incorporated into isolated mitochondria from Neurospora crassa. Then the mitochondrial ribosomes were isolated and submitted to density gradient centrifugation. A preferential labelling of polysomes was observed.
Dingman C. W. +8 more
core +2 more sources
Protocol for Metatranscriptomic analysis of Intestinal Microbiota [PDF]
, 2012 The objective of this publication is to provide the detailed protocol for metartancriptomisc studies of animal intestinal microbiota. The protocol describes isolation of high quality microbial community RNA from the mammalian intestinal content ...
Alvaro Hernandez +4 more
core +2 more sources
Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans
Nature Communications, 2016 Circular RNAs (circRNAs) are broadly expressed in eukaryotic cells, but their molecular mechanism in human disease remains obscure. Here we show that circular antisense non-coding RNA in the INK4 locus (circANRIL), which is transcribed at a locus of ...
L. Holdt +17 more
semanticscholar +1 more source
RNA polymerase I mutant affects ribosomal RNA processing and ribosomal DNA stability
RNA BiologyTranscription is a major contributor to genomic instability. The ribosomal RNA (rDNA) gene locus consists of a head-to-tail repeat of the most actively transcribed genes in the genome.
Christophe Normand +7 more
doaj +1 more source
Ribosomal RNA regulates chromosome clustering during mitosis
Cell Discovery, 2022 Noncoding RNAs are known to associate with mitotic chromosomes, but the identities and functions of chromosome-associated RNAs in mitosis remain elusive. Here, we show that rRNA species associate with condensed chromosomes during mitosis.
Kai Ma +7 more
doaj +1 more source
Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes [PDF]
, 2013 Introduction: In recent years, there has been an exponential increase in the number of studies aiming to understand the biology of exosomes, as well as other extracellular vesicles.
Berent-Maoz B +28 more
core +2 more sources
SARS-CoV-2 targets ribosomal RNA biogenesis
Cell ReportsSummary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hinders host gene expression, curbing defenses and licensing viral protein synthesis and virulence.
V. Talya Yerlici +9 more
doaj +1 more source