Results 41 to 50 of about 1,352,832 (329)
Ribosomal history reveals origins of modern protein synthesis. [PDF]
PLoS ONE, 2012 The origin and evolution of the ribosome is central to our understanding of the cellular world. Most hypotheses posit that the ribosome originated in the peptidyl transferase center of the large ribosomal subunit.
Ajith Harish, Gustavo Caetano-Anollés
doaj +1 more source
Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans
Nature Communications, 2016 Circular RNAs (circRNAs) are broadly expressed in eukaryotic cells, but their molecular mechanism in human disease remains obscure. Here we show that circular antisense non-coding RNA in the INK4 locus (circANRIL), which is transcribed at a locus of ...
L. Holdt +17 more
semanticscholar +1 more source
Ribosomal RNA, the lens into life [PDF]
RNA, 2015 Our world is, to a first approximation, a microbial world—even our own lives are evolutionarily and molecularly linked to that which we cannot see. This “invisible” world contains nearly unfathomable molecular and genetic diversity. Throughout the 20th century, a metaphor of “war against disease” prevailed: Microbes were hunted under the guise of ...
Daniel McDonald +3 more
openaire +3 more sources
Updating the 97% identity threshold for 16S ribosomal RNA OTUs
bioRxiv, 2017 The 16S ribosomal RNA (rRNA) gene is widely used to survey microbial communities. Sequences are often clustered into Operational Taxonomic Units (OTUs) as proxies for species. The canonical clustering threshold is 97% identity, which was proposed in 1994
Robert C. Edgar
semanticscholar +1 more source
RNA polymerase I mutant affects ribosomal RNA processing and ribosomal DNA stability
RNA BiologyTranscription is a major contributor to genomic instability. The ribosomal RNA (rDNA) gene locus consists of a head-to-tail repeat of the most actively transcribed genes in the genome.
Christophe Normand +7 more
doaj +1 more source
Frontiers in Microbiology, 2021 Three out of the seven ribosomal RNA operons in Escherichia coli end in dual terminator structures. Between the two terminators of each operon is a short sequence that we report here to be an sRNA gene, transcribed as part of the ribosomal RNA primary ...
Thomas Søndergaard Stenum +5 more
doaj +1 more source
Loss of the ribosomal RNA methyltransferase NSUN5 impairs global protein synthesis and normal growth
Nucleic Acids Research, 2019 Modifications of ribosomal RNA expand the nucleotide repertoire and thereby contribute to ribosome heterogeneity and translational regulation of gene expression.
C. Heissenberger +22 more
semanticscholar +1 more source
Stochasticity and traffic jams in the transcription of ribosomal RNA: Intriguing role of termination and antitermination [PDF]
Proc. Natl. Acad. Sci. USA 105, 18159-18164 (2008), 2008 In fast growing bacteria, ribosomal RNA (rRNA) is required to be transcribed at very high rates to sustain the high cellular demand on ribosome synthesis. This results in dense traffic of RNA polymerases (RNAP). We developed a stochastic model, integrating results of single-molecule and quantitative in vivo studies of E.
arxiv +1 more source
Heliyon, 2016 Ribosomal translocation catalyzed by EF-G hydrolyzing GTP entails multiple conformational changes of ribosome and positional changes of tRNAs and mRNA in the ribosome.
Ping Xie
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Small Non-Coding RNAs Derived from Eukaryotic Ribosomal RNA
Non-Coding RNA, 2019 The advent of RNA-sequencing (RNA-Seq) technologies has markedly improved our knowledge and expanded the compendium of small non-coding RNAs, most of which derive from the processing of longer RNA precursors.
Marine Lambert, A. Benmoussa, P. Provost
semanticscholar +1 more source