Results 131 to 140 of about 416,109 (272)

DeepSilencer: A Novel Deep Learning Model for Predicting siRNA Knockdown Efficiency [PDF]

arXiv
Background: Small interfering RNA (siRNA) is a promising therapeutic agent due to its ability to silence disease-related genes via RNA interference. While traditional machine learning and early deep learning methods have made progress in predicting siRNA efficacy, there remains significant room for improvement.
arxiv  

In Vivo‐Like Scaffold‐Free 3D In Vitro Models of Muscular Dystrophies: The Case for Anchored Cell Sheet Engineering in Personalized Medicine

Advanced Healthcare Materials, EarlyView.
The scaffold‐free Anchored Cell Sheet Engineering platform is used to create three‐dimensional (3D) in vitro models of skeletal muscle tissue that replicate key features of Duchenne and Myotonic dystrophies. These personalized tissue models, validated by histological, immunostaining, and proteomics analyses, accurately mimic disease phenotypes and ...
Alireza Shahin‐Shamsabadi, John Cappuccitti   +1 more
wiley   +1 more source

RNA Interference as a New Tool in Therapeutics

Food Technology and Biotechnology, 2009
The basic principle of RNA interference, a possible new therapeutic tool, involves destruction of messenger RNA upon interaction with homologous double-stranded RNA present in the cell cytoplasm.
Karmela Barišić, Mirela Matokanović
doaj  

RNA interference therapy in cardiology: will new targets improve therapeutic goals?

Drugs in Context
The discovery of RNA interference in 1998 opened avenues for the manipulation of gene expression, leading to the development of small interfering RNA (siRNA) drugs.
Renata TJ Fazoli, Luciano F Drager, Roberto Kalil-Filho, Giuliano Generoso   +3 more
doaj   +1 more source

Ischemic Myocardium Targeting Peptide‐Guided Nanobubbles for Multimodal Imaging and Treatment of Coronary Microvascular Dysfunction

Advanced Healthcare Materials, EarlyView.
Nanobubbles functionalized with indocyanine green and ischemic myocardium‐targeting peptide effectively target cardiomyocytes and enable the multimodal (fluorescence, ultrasonic, and photoacoustic) imaging of ischemic myocardium in mice with coronary microvascular dysfunction (CMD).
Bo Yu, Ziwei Pang, Jing Zhao, Jingyi Xue, Hsuan Lo, Tiancheng Gu, Ping Zhang, Jiawei Tian, Guo‐Qing Du   +8 more
wiley   +1 more source

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Harnessing Nanohybridized Niclosamide for Precision Mpox Therapeutics

Advanced Healthcare Materials, EarlyView.
This study investigates the potential of nanohybridized niclosamide as a therapeutic agent for Mpox, focusing on enhanced bioavailability, improved antiviral efficacy, and controlled drug release achieved through nanoengineering. The research emphasizes significant advancements in formulation strategies, mechanistic insights, and therapeutic outcomes ...
N. Sanoj Rejinold, Geun‐woo Jin, Jin‐Ho Choy   +2 more
wiley   +1 more source

Median and Small Parsimony Problems on RNA trees [PDF]

arXiv
Motivation: Non-coding RNAs (ncRNAs) express their functions by adopting molecular structures. Specifically, RNA secondary structures serve as a relatively stable intermediate step before tertiary structures, offering a reliable signature of molecular function.
arxiv  

A Wireless Cortical Surface Implant for Diagnosing and Alleviating Parkinson's Disease Symptoms in Freely Moving Animals

Advanced Healthcare Materials, EarlyView.
A wireless cortical surface implant employing graphene electrode arrays diagnoses and alleviates Parkinson's disease symptoms in freely moving animals. The device continuously monitors cortical activity and delivers targeted stimulation, restoring beta–gamma and delta oscillations.
Hongseong Shin, Kyungtae Kim, Jaeseung Lee, Johyeon Nam, Eunha Baeg, Chaeyeon You, Hanseul Choi, Minji Kim, Chun Kee Chung, Jae Geun Kim, Jong Hyun Ahn, Miryung Han, Jibum Kim, Sungchil Yang, Sung Q Lee, Sunggu Yang   +15 more
wiley   +1 more source

Immunoinformatic and molecular docking approaches: siRNA prediction to silence cell surface binding protein of monkeypox virus

Beni-Suef University Journal of Basic and Applied Sciences
Background Monkeypox virus (MPV), an endemic pathogen in Africa, shares clinical similarities with smallpox. Recent reports indicate a concerning increase in the number of MPV cases detected outside its endemic region, highlighting the emergence of a ...
Rahatul Islam, Asif Shahriar, Muhammad Ramiz Uddin, Nour Fatema   +3 more
doaj   +1 more source