Results 61 to 70 of about 331,612 (290)

Nanoparticle‐mediated siRNA delivery systems for cancer therapy

View, 2021
The small interfering RNA (siRNA)‐based therapeutics have raised great attention since the first RNA interference (RNAi)‐derived drug, patisiran, was approved by the US Food and Drug Administration, which represented a landmark in the field of gene ...
Han Gao, Ruoyu Cheng, Hélder A. Santos
doaj   +1 more source

IDN1 and IDN2 are required for de novo DNA methylation in Arabidopsis thaliana. [PDF]

, 2009
DNA methylation is an epigenetic mark affecting genes and transposons. Screening for mutants that fail to establish DNA methylation yielded two we termed "involved in de novo" (idn) 1 and 2.
Ausin, Israel, Chory, Joanne, Jacobsen, Steven E, Mockler, Todd C   +3 more
core  

Prevention of Tendon Adhesions by ERK2 Small Interfering RNAs [PDF]

International Journal of Molecular Sciences, 2013
Tendon adhesions are one of the most concerning complications after surgical repair of flexor tendon injury. Extracellular signal-regulated kinase (ERK) 2 plays crucial roles in fibroblast proliferation and collagen expression which contributes to the formation of tendon adhesions after flexor tendon surgery. Using a chicken model, we have examined the
Shen Liu, Hongjiang Ruan, Cunyi Fan, Xu-jun Li, Fengfeng Li   +4 more
openaire   +3 more sources

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source

Colored petri net modeling of small interfering RNA-mediated messenger RNA degradation

Advanced Biomedical Research, 2016
Background: Mathematical modeling of biological systems is an attractive way for studying complex biological systems and their behaviors. Petri Nets, due to their ability to model systems with various levels of qualitative information, have been wildly ...
Niloofar Nickaeen, Shiva Moein, Zarifeh Heidary, Jafar Ghaisari   +3 more
doaj   +1 more source

Deep sequencing of virus derived small interfering RNAs and RNA from viral particles shows highly similar mutational landscape of a plant virus population. [PDF]

, 2015
RNA viruses exist within a host as a population of mutant sequences, often referred to as quasispecies. Within a host, sequences of RNA viruses constitute several distinct but interconnected pools, such as RNA packed in viral particles, double-stranded ...
Curk, T., Gutiérrez Aguirre, I., Kreuze, J.F., Kutnjak, D., Ravnikar, M., Rupar, M.   +5 more
core   +1 more source

Inhibition of Junín virus replication by small interfering RNAs

Antiviral Research, 2009
Junín virus (JUNV), the etiological agent of the Argentine hemorrhagic fever, has a single-stranded RNA genome with ambisense expression which encodes for five proteins. In previous works we have demonstrated that the Z arenavirus matrix protein represents an attractive target for antiviral therapy.
Artuso, MC, Ellenberg, PC, Scolaro, LA, Damonte, EB, Garcia, CC   +4 more
openaire   +5 more sources

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

EGCG‐LYS Fibrils‐Mediated CircMAP2K2 Silencing Decreases the Proliferation and Metastasis Ability of Gastric Cancer Cells in Vitro and in Vivo

Advanced Science, 2023
Aberrant expression of circular RNAs (circRNAs) has been reported to play an important biological regulatory role in gastric cancer (GC). For the purpose of silencing cancer‐related genes, a new approach for cancer treatment using nanocarriers to deliver
Jiaqi Dong, Zhousan Zheng, Mi Zhou, Yunfei Wang, Jiajie Chen, Junjie Cen, Tiefeng Cao, Taowei Yang, Yi Xu, Guannan Shu, Xuanxuan Lu, Yanping Liang   +11 more
doaj   +1 more source

In vivo and ex vivo regulation of visfatin production by leptin in human and murine adipose tissue : role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways [PDF]

, 2009
Visfatin is an adipogenic adipokine with increased levels in obesity, properties common to leptin. Thus, leptin may modulate visfatin production in adipose tissue (AT).
Bee K. Tan, Chen, Clifford J. Bailey, Cohen, Dielen, Eckel, Fried, Frühbeck, Fukuhara, Haider, Han, Harpal S. Randeva, Havel, Hector, Hendrik Lehnert, James Brown, Jing Chen, Kellerer, Kershaw, Kim, Krzyzanowska, Mahabir, Manjunath Ramanjaneya, Murakami, Otero, Pagano, Pfaffl, Raghu Adya, Sahai, Sandeep, Shimomura, Tan, Van Heek, Vinod Menon, Yang   +34 more
core   +2 more sources